Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Ian A. Simpson"'
Autor:
Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-13 (2023)
Abstract Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron
Externí odkaz:
https://doaj.org/article/b95d22665c3c4e128ec7e5ea69f71b76
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract Background The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of brain iron uptake is
Externí odkaz:
https://doaj.org/article/f0ff6eb5fcb84770986126f54fddb6a5
Autor:
James R. Connor, Kari Duck, Stephanie Patton, Ian A. Simpson, Lynn Marie Trotti, Richard Allen, Christopher J. Earley, David Rye
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-4 (2020)
Abstract Background Iron is crucial for proper functioning of all organs including the brain. Deficiencies and excess of iron are common and contribute to substantial morbidity and mortality. Whereas iron’s involvement in erythropoiesis drives clin
Externí odkaz:
https://doaj.org/article/b4cbf902c2c64c3d9cc28e5f6bb86114
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Iron regulation is essential for cellular energy production. Loss of cellular iron homeostasis has critical implications for both normal function and disease progression. The H63D variant of the HFE gene is the most common gene va
Externí odkaz:
https://doaj.org/article/363b5954ddf74a6d863e27df3b2b0e69
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 588-597 (2011)
The lithium–pilocarpine model mimics most features of human temporal lobe epilepsy. Following our prior studies of cerebral metabolic changes, here we explored the expression of transporters for glucose (GLUT1 and GLUT3) and monocarboxylates (MCT1
Externí odkaz:
https://doaj.org/article/b143df9e0f474fea99d36b3301c8249f
Publikováno v:
Journal of Neurochemistry. 165:625-642
Publikováno v:
American Annals of the Deaf. 167:644-671
Publikováno v:
Pharmacological Reports. 74:696-708
Publikováno v:
Wood Science and Technology. 56:1127-1148
High pressure (20 MPa), cyclic, supercritical carbon dioxide (scCO2) treatments can reduce the moisture content of green Pinus radiata sapwood from 150–200% to 35–40%. Such treatments can be used as a dewatering pre-treatment before the kiln-dryi
Autor:
Stephanie L. Baringer, Avraham S. Lukacher, Kondaiah Palsa, Hyosung Kim, Ethan S. Lippmann, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Publikováno v:
bioRxiv
Excessive brain iron accumulation is observed in early in the onset of Alzheimer’s disease, notably prior to widespread proteinopathy. These findings suggest that increases in brain iron levels are due to a dysregulation of the iron transport mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4da8b9b2d6106d7b6d0a6b444ee3fb
https://europepmc.org/articles/PMC10245582/
https://europepmc.org/articles/PMC10245582/