Zobrazeno 1 - 10
of 546
pro vyhledávání: '"Ian A. Lewis"'
Autor:
Maria J. Arzamendi, Yasaman B. Habibyan, Manon Defaye, Adam Shute, Cristiane H. Baggio, Ronald Chan, Christina Ohland, Dominique G. Bihan, Ian A. Lewis, Keith A. Sharkey, Kathy D. McCoy, Christophe Altier, Markus B. Geuking, Yasmin Nasser
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Background Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD shows a sex bi
Externí odkaz:
https://doaj.org/article/2b991dd691bb42f6b7f6046c71ffedf6
Autor:
Samira A. Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L. Prince, Ian A. Lewis, Jane Shearer, Åsa V. Keita, Johan D. Söderholm, Timothy E. Shutt, Derek M. McKay
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTGut bacteria provide benefits to the host and have been implicated in inflammatory bowel disease (IBD), where adherent-invasive E. coli (AIEC) pathobionts (e.g., strain LF82) are associated with Crohn’s disease. E. coli-LF82 causes fragment
Externí odkaz:
https://doaj.org/article/4210087e373c4f0c8ae7f8feeb913bb8
Autor:
Kirsty Brown, Carolyn A. Thomson, Soren Wacker, Marija Drikic, Ryan Groves, Vina Fan, Ian A. Lewis, Kathy D. McCoy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Commensal microbes contribute considerably to mammalian metabolism. Here the authors report the relative contributions of microbiome, age and sex to metabolism throughout the body and uncover age- and sex- specificity in how microbes affect metabolit
Externí odkaz:
https://doaj.org/article/6b529e092cf44d43a84398c113fa83ef
Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst
Autor:
Kira L. Tomlinson, Sebastián A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112064- (2023)
Summary: Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that S. aureus impai
Externí odkaz:
https://doaj.org/article/767b8e41e2d14568853587d3c6c14abe
Autor:
Thomas Rydzak, Ryan A. Groves, Ruichuan Zhang, Raied Aburashed, Rajnigandha Pushpker, Maryam Mapar, Ian A. Lewis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
It is currently slow to identify bloodstream infection pathogens. Here the authors report a rapid metabolic preference assay that uses the pattern of metabolic fluxes observed in ex-vivo microbial cultures to identify common pathogens and determine t
Externí odkaz:
https://doaj.org/article/95938fd47dd444269abdb9b5b34996bb
Autor:
Adam Shute, Blanca E. Callejas, ShuHua Li, Arthur Wang, Timothy S. Jayme, Christina Ohland, Ian A. Lewis, Brian T. Layden, André G. Buret, Derek M. McKay
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Background Studies on the inhibition of inflammation by infection with helminth parasites have, until recently, overlooked a key determinant of health: the gut microbiota. Infection with helminths evokes changes in the composition of their h
Externí odkaz:
https://doaj.org/article/b6d4aaef4bb84f2aba94fc3c52780896
Autor:
Mehdi Mohammadi, Stephanie L. Bishop, Raied Aburashed, Saad Luqman, Ryan A. Groves, Dominique G. Bihan, Thomas Rydzak, Ian A. Lewis
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Metabolomics is a mainstream strategy for investigating microbial metabolism. One emerging application of metabolomics is the systematic quantification of metabolic boundary fluxes – the rates at which metabolites flow into and out of cultured cell
Externí odkaz:
https://doaj.org/article/74738aaf3e2f4be69464834b3f93216c
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Microbes have diverse metabolic capabilities and differences in these phenotypes are critical for differentiating strains, species, and broader taxa of microorganisms. Recent advances in liquid chromatography-mass spectrometry (LC-MS) allow researche
Externí odkaz:
https://doaj.org/article/91b45a4ba59145fbaf50bf0b8419c126
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Inflammatory bowel disease (IBD), comprising Crohn’s disease and Ulcerative colitis, is a relapsing and remitting disease of the gastrointestinal tract, presenting with chronic inflammation, ulceration, gastrointestinal bleeding, and abdominal pain
Externí odkaz:
https://doaj.org/article/7a54d96ecf0a4a62904b588868001a1c
Autor:
Henrik Almblad, Trevor E. Randall, Fanny Liu, Katherine Leblanc, Ryan A. Groves, Weerayuth Kittichotirat, Geoffrey L. Winsor, Nicolas Fournier, Emily Au, Julie Groizeleau, Jacquelyn D. Rich, Yuefei Lou, Elise Granton, Laura K. Jennings, Larissa A. Singletary, Tara M. L. Winstone, Nathan M. Good, Roger E. Bumgarner, Michael F. Hynes, Manu Singh, Maria Silvina Stietz, Fiona S. L. Brinkman, Ayush Kumar, Ann Karen Cornelia Brassinga, Matthew R. Parsek, Boo Shan Tseng, Ian A. Lewis, Bryan G. Yipp, Justin L. MacCallum, Joe Jonathan Harrison
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility, bi
Externí odkaz:
https://doaj.org/article/6182b1bdedda46118764d49013acab00