Výsledky vyhledávání - "Ian A. Clarke"

Akademický článek

The Structure of Spiroplasma Virus 4: Exploring the Capsid Diversity of the Microviridae

Autor: Mario Mietzsch, Shweta Kailasan, Antonette Bennett, Paul Chipman, Bentley Fane, Juha T. Huiskonen, Ian N. Clarke, Robert McKenna

Publikováno v: Viruses, Vol 16, Iss 7, p 1103 (2024)

Spiroplasma virus 4 (SpV4) is a bacteriophage of the Microviridae, which packages circular ssDNA within non-enveloped T = 1 icosahedral capsids. It infects spiroplasmas, which are known pathogens of honeybees. Here, the structure of the SpV4 virion i

Externí odkaz: https://doaj.org/article/d837cfe946374f07a31dec158ee1e2b4

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Akademický článek

An inducible transposon mutagenesis approach for the intracellular human pathogen Chlamydia trachomatis [version 1; peer review: 2 approved]

Autor: Sarah A. Pearson, David W. Cleary, Nicholas R. Thomson, David J. Lampe, Ian N. Clarke, Colette E. O'Neill, Jade Forster, Rachel J. Skilton

Publikováno v: Wellcome Open Research, Vol 6 (2021)

Background: Chlamydia trachomatis is a prolific human pathogen that can cause serious long-term conditions if left untreated. Recent developments in Chlamydia genetics have opened the door to conducting targeted and random mutagenesis experiments to

Externí odkaz: https://doaj.org/article/71bf456426164945a72f754b32424d84

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Akademický článek

Progress towards an inducible, replication-proficient transposon delivery vector for Chlamydia trachomatis [version 1; peer review: 2 approved]

Autor: Rachel J. Skilton, Colette O'Neill, Nicholas R. Thomson, David J. Lampe, Ian N. Clarke

Publikováno v: Wellcome Open Research, Vol 6 (2021)

Background Genetic systems have been developed for Chlamydia but the extremely low transformation frequency remains a significant bottleneck. Our goal is to develop a self-replicating transposon delivery vector for C. trachomatis which can be expande

Externí odkaz: https://doaj.org/article/02d4ed1c1f324244a0b5883d3455bfa8

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Akademický článek

High-resolution genotyping of Lymphogranuloma Venereum (LGV) strains of Chlamydia trachomatis in London using multi-locus VNTR analysis-ompA genotyping (MLVA-ompA).

Autor: Chloe Manning, Colette O'Neill, Ian N Clarke, Monica Rebec, Penelope R Cliff, Peter Marsh

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0254233 (2021)

BackgroundLymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis strains with ompA genotypes L1 to L3. An LGV epidemic associated with the L2b genotype has emerged in the past few decades amongst men who have sex with men (MSM). C. trachom

Externí odkaz: https://doaj.org/article/0bed3fd6977d4bf58fd588efe7591aa6

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Akademický článek

Diversity in Chlamydial plasmids.

Autor: Kolos V Szabo, Colette E O'Neill, Ian N Clarke

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0233298 (2020)

BACKGROUND:Evolutionary studies have been conducted that have investigated the chromosomal variance in the genus of Chlamydia. However, no all-encompassing genus-wide comparison has been performed on the plasmid. Therefore, there is a gap in the curr

Externí odkaz: https://doaj.org/article/82889e1194d246c5bc77a77740de9c91

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Akademický článek

Genetic Transformation of a C. trachomatis Ocular Isolate With the Functional Tryptophan Synthase Operon Confers an Indole-Rescuable Phenotype

Autor: Colette Elizabeth O'Neill, Rachel Jane Skilton, Sarah Ann Pearson, Simone Filardo, Patiyan Andersson, Ian Nicholas Clarke

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Different strains are associated with ocular or urogenital infections, and a proposed mechanism that may explain this ti

Externí odkaz: https://doaj.org/article/805d769343cb4bbe82c87c5a884e1b47

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