Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ian A Shiels"'
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146022 (2016)
PURPOSE:Inflammation may contribute to the pathogenesis of specific cardiovascular diseases, but it is uncertain if mediators released during the inflammatory process will affect the continued efficacy of drugs used to treat clinical signs of the car
Externí odkaz:
https://doaj.org/article/3b41e4b05935430c94f9228b588cd53f
Autor:
Fazrena Nadia Md Akhir, Mohd Hezmee Mohd Noor, Keith Weng Kit Leong, Jamileh A. Nabizadeh, Helga D. Manthey, Stefan E. Sonderegger, Jenny Nga Ting Fung, Crystal E. McGirr, Ian A. Shiels, Paul C. Mills, Trent M. Woodruff, Barbara E. Rolfe
Publikováno v:
Antibodies, Vol 10, Iss 1, p 2 (2021)
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptor
Externí odkaz:
https://doaj.org/article/ed5826c8ab7746d6bb9209f09dfcb2ce
Autor:
Jenny N. Fung, Trent M. Woodruff, Barbara E. Rolfe, Keith Weng Kit Leong, Paul C. Mills, Helga D. Manthey, Jamileh A. Nabizadeh, Stefan Eugen Sonderegger, Mohd Hezmee Mohd Noor, Fazrena Nadia Md Akhir, Ian A. Shiels, Crystal McGirr
Publikováno v:
Antibodies
Volume 10
Issue 1
Antibodies, Vol 10, Iss 2, p 2 (2021)
Volume 10
Issue 1
Antibodies, Vol 10, Iss 2, p 2 (2021)
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ac367d39de0fe64e8703feb3c16396
Publikováno v:
The Veterinary Journal. 203:161-168
The histological features of feline hypertrophic cardiomyopathy (HCM) have been well documented, but there are no reports describing the histological features in mild pre-clinical disease, since cats are rarely screened for the disease in the early s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41570f7277c4bd88394baa7c4fc384a9
https://doi.org/10.1016/j.tvjl.2014.11.018
https://doi.org/10.1016/j.tvjl.2014.11.018
Autor:
Paul C. Mills, Ian A. Shiels, Tyson A. Moore, Kuan Hua Khor, Ristan M. Greer, Thiruma V. Arumugam
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146022 (2016)
PLoS ONE
PLoS ONE
Purpose Inflammation may contribute to the pathogenesis of specific cardiovascular diseases, but it is uncertain if mediators released during the inflammatory process will affect the continued efficacy of drugs used to treat clinical signs of the car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109d85fde30a046e223cc973885dc097
http://europepmc.org/articles/PMC4699762?pdf=render
http://europepmc.org/articles/PMC4699762?pdf=render
Autor:
Barbara E. Rolfe, Helga D. Manthey, Alma Zernecke, Ian A. Shiels, Trent M. Woodruff, Anita C Thomas, Stephen M. Taylor
Publikováno v:
The FASEB Journal. 25:2447-2455
The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis. Using real-time PCR, we determined that ApoE(-/-) mice fed a normal diet expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d41b230decc5b07f206f555b3398be
https://doi.org/10.1096/fj.10-174284
https://doi.org/10.1096/fj.10-174284
Autor:
Mohd Noor Mohd Hezmee, Barbara E. Rolfe, M.T. Kyaw-Tanner, Ian A. Shiels, Paul C. Mills, Jia Yu Peppermint Lee, Trent M. Woodruff
Publikováno v:
Veterinary Immunology and Immunopathology. 139:50-56
Mammary tumors are among the most common neoplastic conditions in dogs, and there is evidence that inflammation plays a role in the development of some tumor types in dogs. The complement system is a major participant in the inflammatory process and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27134949252c9b936155e95cbdd2384
https://doi.org/10.1016/j.vetimm.2010.08.005
https://doi.org/10.1016/j.vetimm.2010.08.005
Autor:
Stephen M. Taylor, Lavinia M. Proctor, Ian A. Shiels, Trent M. Woodruff, Indumathy B. Mahadevan, H. Ming Williams, Anna J. Strachan
Publikováno v:
International Immunopharmacology. 6:1224-1232
Systemic activation of complement is a pathophysiological response common to severe disturbances such as hemorrhagic shock, major burn injury and sepsis. Intravenous infusion of cobra venom factor (CVF) has been used as an animal model of acute respi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ba9bbd6c2423a14ea6d38fb507d20f
https://doi.org/10.1016/j.intimp.2006.03.002
https://doi.org/10.1016/j.intimp.2006.03.002
Autor:
Lavinia M. Proctor, Kurt J. De Vos, Kathryn M. Buller, Trent M. Woodruff, Peter N. Monk, Annie B. Shek, Ian A. Shiels, Stephen M. Taylor, Hua M. Williams, Sandra Pollitt, James W. Crane
Publikováno v:
The FASEB Journal. 20:1407-1417
The complement system is thought to be involved in the pathogenesis of numerous neurological diseases, although its precise role remains controversial. In this study we used orally active C5a receptor antagonists (PMX53 and PMX205) developed in our l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2695ea6fb84be5edd7cd54d8980b4f
https://doi.org/10.1096/fj.05-5814com
https://doi.org/10.1096/fj.05-5814com
Autor:
Sandra Pollitt, Hua M. Williams, Helga D. Manthey, Stephen M. Taylor, Ian A. Shiels, Lavinia M. Proctor, Indumathy B. Mahadevan, Trent M. Woodruff, Shelli Z. Stocks
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 314:811-817
We have previously shown that complement factor 5a (C5a) plays a role in the pathogenesis of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats by using the selective, orally active C5a antagonist AcF-[OP(d-Cha)WR]. This study tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a7cdbc4d126db81930aca3633a6178
https://doi.org/10.1124/jpet.105.086835
https://doi.org/10.1124/jpet.105.086835