Výsledky vyhledávání - "Ian A Parish"

Akademický článek

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Autor: Roybel R Ramiscal, Ian A Parish, Robert S Lee-Young, Jeffrey J Babon, Julianna Blagih, Alvin Pratama, Jaime Martin, Naomi Hawley, Jean Y Cappello, Pablo F Nieto, Julia I Ellyard, Nadia J Kershaw, Rebecca A Sweet, Christopher C Goodnow, Russell G Jones, Mark A Febbraio, Carola G Vinuesa, Vicki Athanasopoulos

Publikováno v: eLife, Vol 4 (2015)

T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional rep

Externí odkaz: https://doaj.org/article/7bf1a7c862fb4da5805e2cb6c10ee4a4

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Akademický článek

FixNCut: single-cell genomics through reversible tissue fixation and dissociation

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-36 (2024)

Abstract The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can further increase robustness and reproducibility by avoiding artifacts introduced du

Externí odkaz: https://doaj.org/article/d1ab6d70f44f4bfd844fa1f4befa4917

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Akademický článek

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechanism by which A2AR is regulated

Externí odkaz: https://doaj.org/article/b9c76314c12142099494e8759d06a025

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Akademický článek

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation

Autor: Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients trea

Externí odkaz: https://doaj.org/article/c8e517cb608a45a58a1cfaec14b8b317

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Akademický článek

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Autor: Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X. Y. Chen, Deborah Meyran, Kirsten L. Todd, Emma V. Petley, Sherly Mardiana, Christina Mølck, Gregory D. Stewart, Benjamin J. Solomon, Ian A. Parish, Paul J. Neeson, Simon J. Harrison, Lev M. Kats, Imran G. House, Phillip K. Darcy, Paul A. Beavis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors show that CRISPR/Cas9 mediated deletion of A2AR enhances CAR T cell effector fu

Externí odkaz: https://doaj.org/article/483b1c1b715b445cad3cbef377ef8466

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Akademický článek

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epige

Externí odkaz: https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd

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Akademický článek

Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy

Autor: Simone Nüssing, Joseph A. Trapani, Ian A. Parish

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Immunotherapy has revolutionized the treatment of cancer. Nevertheless, the majority of patients do not respond to therapy, meaning a deeper understanding of tumor immune evasion strategies is required to boost treatment efficacy. The vast majority o

Externí odkaz: https://doaj.org/article/25032322cf0745daa544ad50bae249ad

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Akademický článek

The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen

Autor: Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. Parish

Publikováno v: Cell Reports, Vol 24, Iss 3, Pp 577-584 (2018)

Summary: Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin li

Externí odkaz: https://doaj.org/article/f1df04bb8c3940ffbd9e365a5f64deff

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