Cediranib Maleate—From Crystal Structure Toward Materials Control

Autor: Anna Pettersen, Martin F. Jones, Ronald John Roberts, Simon N. Black, Helen P. Wheatcroft, Ian Michael Mcfarlane

Publikováno v: Journal of Pharmaceutical Sciences. 109:1509-1518

Cediranib maleate is an active pharmaceutical ingredient (API) in phase III of development within AstraZeneca's oncology portfolio. Analysis of the crystal structure of this API confirmed that the selected salt form was robust. The salt formation ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e698aaa17d5e3cac8791d71c56cc4e59
https://doi.org/10.1016/j.xphs.2019.12.017

Abiotic Deposition of Fe Complexes onto Leptothrix Sheaths

Autor: Tatsuki Kunoh, Hideki Hashimoto, Ian R. McFarlane, Naoaki Hayashi, Tomoko Suzuki, Eisuke Taketa, Katsunori Tamura, Mikio Takano, Mohamed Y. El-Naggar, Hitoshi Kunoh, Jun Takada

Publikováno v: Biology, Vol 5, Iss 2, p 26 (2016)

Bacteria classified in species of the genus Leptothrix produce extracellular, microtubular, Fe-encrusted sheaths. The encrustation has been previously linked to bacterial Fe oxidases, which oxidize Fe(II) to Fe(III) and/or active groups of bacterial

Externí odkaz: https://doaj.org/article/d1734bbbd98540acba095ea9b8d059cc

Electrostatic Assemblies of Single-Walled Carbon Nanotubes and Sequence-Tunable Peptoid Polymers Detect a Lectin Protein and Its Target Sugars

Autor: Ronald N. Zuckermann, Markita P. Landry, Linda Chio, Ian R. McFarlane, Mark Kline, Jackson Travis Del Bonis-O'Donnell, Jae Hong Kim

Publikováno v: Nano letters. 19(11)

A primary limitation to real-time imaging of metabolites and proteins has been the selective detection of biomolecules that have no naturally occurring or stable molecular recognition counterparts. We present developments in the design of synthetic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518fa6f7a2e54d8157555f60172b924f
https://pubmed.ncbi.nlm.nih.gov/30958010

Advances in Nanomaterials for Brain Microscopy

Autor: Markita P. Landry, Ian R. McFarlane, Linda Chio, Gabriel Dorlhiac, Jackson Travis Del Bonis-O'Donnell

Publikováno v: Nano research, vol 11, iss 10
Del Bonis-O’Donnell, JT; Chio, L; Dorlhiac, GF; McFarlane, IR; & Landry, MP. (2018). Advances in nanomaterials for brain microscopy. Nano Research, 11(10), 5144-5172. doi: 10.1007/s12274-018-2145-2. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9546k727

© 2018, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature. Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1787d00727ebadc323ef8ad675c354
https://escholarship.org/uc/item/9546k727

Stochastic Simulation of Dopamine Neuromodulation for Implementation of Fluorescent Neurochemical Probes in the Striatal Extracellular Space

Autor: Ian R. McFarlane, Abraham G. Beyene, Markita P. Landry, Rebecca L. Pinals

Publikováno v: ACS chemical neuroscience, vol 8, iss 10
Beyene, AG; McFarlane, IR; Pinals, RL; & Landry, MP. (2017). Stochastic Simulation of Dopamine Neuromodulation for Implementation of Fluorescent Neurochemical Probes in the Striatal Extracellular Space. ACS Chemical Neuroscience, 8(10), 2275-2289. doi: 10.1021/acschemneuro.7b00193. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5gf0q89p

Imaging the dynamic behavior of neuromodulatory neurotransmitters in the extracelluar space arising from individual quantal releases would constitute a major advance in neurochemical imaging. Spatial and temporal resolution of these highly stochastic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455e5351124c823d117a73703b70776a
https://escholarship.org/uc/item/5gf0q89p