Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ian A Baines"'
Autor:
Jackie C. Bloomer, Melinda J. Reese, Stephen E. Clarke, Ian A. Baines, Cerys A. Lovatt, Andrew W Harrell, Jeffrey L. Ambroso, Liangfu Chen, Harma Ellens, Eric Yang, Melanie Z. Sakatis, Andrew Ayrton, Maxine A. Taylor
Publikováno v:
Chemical Research in Toxicology. 25:2067-2082
Drug-induced liver injury is the most common cause of market withdrawal of pharmaceuticals, and thus, there is considerable need for better prediction models for DILI early in drug discovery. We present a study involving 223 marketed drugs (51% assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c08214c430cf0bef6e6d94714880e5
https://doi.org/10.1021/tx300075j
https://doi.org/10.1021/tx300075j
Autor:
Stephen E. Clarke, Melinda J. Reese, Ian A. Baines, Andrew W Harrell, Liangfu Chen, Melanie Z. Sakatis, Andy Ayrton, Lei Zhu, Jeffrey L. Ambroso, Eric Yang, Maxine A. Taylor
Publikováno v:
Chemico-Biological Interactions. 192:60-64
Metabolic bioactivation is widely considered an undesirable event and a likely prerequisite step in the expression of drug-induced hepatotoxicity and hypersensitivity. Reducing bioactivation risk early in drug discovery, therefore, may help reduce co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56710f9cc9a18734baa5bdb21f1ed538
https://doi.org/10.1016/j.cbi.2010.10.005
https://doi.org/10.1016/j.cbi.2010.10.005
Autor:
Christopher G. Proud, Daniel D. Williams, Deborah C.I. Goberdhan, Ian A. Baines, Clive Wilson, José A. Botella
Publikováno v:
Insect Biochemistry and Molecular Biology. 31:839-847
Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular signalling molecules within the MAP kinase family. Molecular genetic analysis of a highly evolutionarily conserved Drosophila JNK homologue, DJNK, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a92b49c7ec04d7086c0ca69182b269d
https://doi.org/10.1016/s0965-1748(01)00029-7
https://doi.org/10.1016/s0965-1748(01)00029-7
Publikováno v:
Drug discovery today. 6(21)
The clinical success of a compound is often curtailed because of inadequate safety, pharmacokinetics or efficacy. Human tissue can be used to identify the potential shortcomings of new drugs before they undergo testing in man. This review highlights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abd9ced186f6e72e96ff6582f80f3ef
https://pubmed.ncbi.nlm.nih.gov/11677169
https://pubmed.ncbi.nlm.nih.gov/11677169
Autor:
Benjamin L.J. Webb, Christopher G. Proud, Robert G.J. Vries, Jonathan A. Cooper, Xuemin Wang, Andrew J. Waskiewicz, Andrea Flynn, Ian A. Baines
Publikováno v:
The Journal of biological chemistry. 273(16)
Initiation factor eIF4E binds to the 5'-cap of eukaryotic mRNAs and plays a key role in the mechanism and regulation of translation. It may be regulated through its own phosphorylation and through inhibitory binding proteins (4E-BPs), which modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442ad97f3fa688efb5960122743c04ce
https://pubmed.ncbi.nlm.nih.gov/9545260
https://pubmed.ncbi.nlm.nih.gov/9545260