Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Ian Collins"'
Autor:
Habib Bouguenina, Stephanos Nicolaou, Yann-Vaï Le Bihan, Elizabeth A. Bowling, Cheyenne Calderon, John J. Caldwell, Brinley Harrington, Angela Hayes, P. Craig McAndrew, Costas Mitsopoulos, Fernando Jr. Sialana, Andrea Scarpino, Mark Stubbs, Arjun Thapaliya, Siddhartha Tyagi, Hannah Z. Wang, Francesca Wood, Rosemary Burke, Florence Raynaud, Jyoti Choudhary, Rob L.M. van Montfort, Amine Sadok, Thomas F. Westbrook, Ian Collins, Rajesh Chopra
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107059- (2023)
Summary: To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous IMiDs/CeLMoDs based ta
Externí odkaz:
https://doaj.org/article/deed144041474c6d99c938d0c74b984d
Autor:
Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber, Peter Gibbs
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely to ever be answered by clinical trials. However, the largely unrealise
Externí odkaz:
https://doaj.org/article/dde2958b8619435fbac30562014e21eb
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/84ee4a22a82548a5afd07ac8080ed81b
Autor:
François Saint-Dizier, Thomas P. Matthews, Aaron M. Gregson, Hugues Prevet, Tatiana McHardy, Giampiero Colombano, Harry Saville, Martin Rowlands, Caroline Ewens, P. Craig McAndrew, Kathy Tomlin, Delphine Guillotin, Grace Wing-Yan Mak, Konstantinos Drosopoulos, Ioannis Poursaitidis, Rosemary Burke, Rob van Montfort, Spiros Linardopoulos, Ian Collins
Publikováno v:
Journal of Medicinal Chemistry. 66:2622-2645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f73e0f0b4b05d327b515768b64a1872
https://doi.org/10.1021/acs.jmedchem.2c01591
https://doi.org/10.1021/acs.jmedchem.2c01591
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/c64d9e588683492b8e6930305754c0b6
Autor:
Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins
Publikováno v:
Molecules, Vol 27, Iss 3, p 817 (2022)
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HS
Externí odkaz:
https://doaj.org/article/107fca8fd5c94697bed8fa0f96ed1083
Autor:
Jill E. Hunter, Amy E. Campbell, Nicola L. Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A. Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D. Sudhindar, Ruchi Shukla, Philip J. Brownridge, Hayden L. Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Ian Collins, Michelle D. Garrett, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2063-2086
Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that Eµ-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df12386d5171f9c615727f2b67ddab70
https://doi.org/10.1042/bcj20220102
https://doi.org/10.1042/bcj20220102
Autor:
Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2087-2113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420474f3df9a1bc6e42295d95643c992
https://doi.org/10.1042/bcj20220089
https://doi.org/10.1042/bcj20220089
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
Supplementary Figures 1-4 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152e6b9e2a7c0fc3cf17558fd7b2c7b2
https://doi.org/10.1158/1535-7163.22496215.v1
https://doi.org/10.1158/1535-7163.22496215.v1
Autor:
Michelle D. Garrett, Ian Collins, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, Wynne Aherne, Neil T. Thompson, John J. Caldwell, Gowri Vijayaraghavan, Lisa Pickard, Alan Henley, Simon P. Heaton, Ruth Ruddle, Paul D. Eve, Alexis de Haven Brandon, Melanie Valenti, Lisa-Jane K. Hunter, Mike I. Walton, Timothy A. Yap
Supplementary Figure Legends and Supplementary Table 1 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67936b34bb07aa265992163ae6426afc
https://doi.org/10.1158/1535-7163.22496218.v1
https://doi.org/10.1158/1535-7163.22496218.v1