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Autor:
Darell D. Bigner, Richard A. Beers, Ian A. J. Lorimer, Charles N. Pegram, Ira Pastan, Andrea Keppler-Hafkemeyer
Publikováno v:
Proceedings of the National Academy of Sciences. 93:14815-14820
EGFRvIII is a mutant epidermal growth factor receptor found in glioblastoma, and in carcinoma of the breast, ovary, and lung. The mutant receptor has a deletion in its extracellular domain that results in the formation of a new, tumor-specific extrac