Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ian, Wheeldon"'
Autor:
Adithya Ramesh, Varun Trivedi, Sangcheon Lee, Aida Tafrishi, Cory Schwartz, Amirsadra Mohseni, Mengwan Li, Stefano Lonardi, Ian Wheeldon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract High throughput CRISPR screens are revolutionizing the way scientists unravel the genetic underpinnings of engineered and evolved phenotypes. One of the critical challenges in accurately assessing screening outcomes is accounting for the var
Externí odkaz:
https://doaj.org/article/4194a4ba4e654adda3d79a7ea036be11
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Simultaneous saccharification and fermentation (SSF) is effective for minimizing sugar inhibition during high solids fermentation of biomass solids to ethanol. However, fungal enzymes used during SSF are optimal between 50 and 60 °C, wherea
Externí odkaz:
https://doaj.org/article/0594db33452e446d895bf53301eaa834
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The successful use of CRISPR-based mutagenesis in non-conventional microorganisms requires high activity sgRNAs. Here, the authors present DeepGuide, a neural network-based architecture, that learns from genome-wide CRISPR activity profiles to accura
Externí odkaz:
https://doaj.org/article/a11c8ef126f549f784c9758190315fda
Publikováno v:
Metabolic Engineering Communications, Vol 15, Iss , Pp e00208- (2022)
The thermotolerant yeast Kluyveromyces marxianus has gained significant attention in recent years as a promising microbial candidate for industrial biomanufacturing. Despite several contributions to the expanding molecular toolbox for gene expression
Externí odkaz:
https://doaj.org/article/47d412161d0c4185af06f362818dd7b0
Autor:
Mengwan Li, Xuye Lang, Marcos Moran Cabrera, Sawyer De Keyser, Xiyan Sun, Nancy Da Silva, Ian Wheeldon
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive. A biochemical proc
Externí odkaz:
https://doaj.org/article/3ccffffc38fa41fa8154df23b705581a
Publikováno v:
Chem catalysis. 2(10)
Biopolymer-scaffold modification is widely used to enhance enzyme catalysis. A central challenge is predicting the effects of scaffold position on enzyme properties. Here, we use a computational-experimental approach to develop a model for the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd954ed45192107e6464777466ecadb
https://pubmed.ncbi.nlm.nih.gov/36569428
https://pubmed.ncbi.nlm.nih.gov/36569428
Publikováno v:
Metabolic Engineering Communications, Vol 11, Iss , Pp e00145- (2020)
Kluyveromyces marxianus is an emerging host for metabolic engineering. This thermotolerant yeast is the fastest growing eukaryote, has high flux through the TCA cycle, and can metabolize a broad range of C5, C6, and C12 carbon sources. In comparison
Externí odkaz:
https://doaj.org/article/5c58437913f7433682c78bd2d5bf005f
Publikováno v:
Synthetic and Systems Biotechnology, Vol 2, Iss 3, Pp 198-207 (2017)
Microbial production of chemicals and proteins from biomass-derived and waste sugar streams is a rapidly growing area of research and development. While the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to et
Externí odkaz:
https://doaj.org/article/2b0e3310e682404d9771548f261c2835
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background The thermotolerant yeast Kluyveromyces marxianus shows promise as an industrial host for the biochemical production of fuels and chemicals. Wild-type strains are known to ferment high titers of ethanol and can effectively convert
Externí odkaz:
https://doaj.org/article/ea7b736d6a7c49ec934a997cf4118fba
Publikováno v:
Biotechnology and Bioengineering. 119:3623-3631
Yarrowia lipolytica is a metabolic engineering host of growing industrial interest due to its ability to metabolize hydrocarbons, fatty acids, glycerol, and other renewable carbon sources. This dimorphic yeast undergoes a stress-induced transition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90acd44a2c060f65cd4df2b740071c6b
https://doi.org/10.1002/bit.28219
https://doi.org/10.1002/bit.28219