Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Ian, Smyth"'
1
Akademický článek
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
Autor: Nataliya Gorinski, Monika Bijata, Sonal Prasad, Alexander Wirth, Dalia Abdel Galil, Andre Zeug, Daria Bazovkina, Elena Kondaurova, Elizabeth Kulikova, Tatiana Ilchibaeva, Monika Zareba-Koziol, Francesco Papaleo, Diego Scheggia, Gaga Kochlamazashvili, Alexander Dityatev, Ian Smyth, Adam Krzystyniak, Jakub Wlodarczyk, Diethelm W. Richter, Tatyana Strekalova, Stephan Sigrist, Claudia Bang, Lisa Hobuß, Jan Fiedler, Thomas Thum, Vladimir S. Naumenko, Ghanshyam Pandey, Evgeni Ponimaskin
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implica
Externí odkaz: https://doaj.org/article/b7ca995a09f14264a865413198bdb889
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2
Akademický článek
Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice
Autor: Fenny Wiradjaja, Denny L. Cottle, Lynelle Jones, Ian Smyth
Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 6, Pp 1426-1433 (2013)
SUMMARY Fras1-related extracellular matrix protein 1 (FREM1) is required for epidermal adhesion during embryogenesis, and mice lacking the gene develop fetal skin blisters and a range of other developmental defects. Mutations in members of the FRAS/F
Externí odkaz: https://doaj.org/article/a19c57f8c4fd44e08e233085e5a3ecb6
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3
Interferons limit autoantigen-specific CD8
Autor: Gaurang, Jhala, Balasubramanian, Krishnamurthy, Thomas C, Brodnicki, Tingting, Ge, Satoru, Akazawa, Claudia, Selck, Prerak M, Trivedi, Evan G, Pappas, Leanne, Mackin, Nicola, Principe, Erwan, Brémaud, David J, De George, Louis, Boon, Ian, Smyth, Jonathan, Chee, Thomas W H, Kay, Helen E, Thomas
Publikováno v: Cell reports. 39(4)
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese diabetic (NOD) mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97fab22d01f9071dfdfc3f0f26da54e5
https://pubmed.ncbi.nlm.nih.gov/35476975
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4
An investigation into apprenticeship completion and retention in Northern Ireland: a social exchange perspective
Autor: Chilemwa Zimba, Ian Smyth
Publikováno v: International Journal of Training and Development. 23:89-115
This paper investigates effective strategies for enhancing completion rates of apprentices and their retention after completing their training. The study was cross sectional and qualitative, involving semi‐structured interviews with managers and fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8317e9e8fc52817f8263bed8daca3474
https://doi.org/10.1111/ijtd.12146
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8
Akademický článek
Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
Autor: Lisenka E L M Vissers, Timothy C Cox, A Murat Maga, Kieran M Short, Fenny Wiradjaja, Irene M Janssen, Fernanda Jehee, Debora Bertola, Jia Liu, Garima Yagnik, Kiyotoshi Sekiguchi, Daiji Kiyozumi, Hans van Bokhoven, Carlo Marcelis, Michael L Cunningham, Peter J Anderson, Simeon A Boyadjiev, Maria Rita Passos-Bueno, Joris A Veltman, Ian Smyth, Michael F Buckley, Tony Roscioli
Publikováno v: PLoS Genetics, Vol 7, Iss 9, p e1002278 (2011)
The premature fusion of the paired frontal bones results in metopic craniosynostosis (MC) and gives rise to the clinical phenotype of trigonocephaly. Deletions of chromosome 9p22.3 are well described as a cause of MC with variably penetrant midface h
Externí odkaz: https://doaj.org/article/af1e6f0904f7438a819309fe39440171
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10
Akademický článek
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
Autor: Sabine Jurado, Ian Smyth, Bryce van Denderen, Nora Tenis, Andrew Hammet, Kimberly Hewitt, Jane-Lee Ng, Carolyn J McNees, Sergei V Kozlov, Hayato Oka, Masahiko Kobayashi, Lindus A Conlan, Timothy J Cole, Ken-Ichi Yamamoto, Yoshihito Taniguchi, Shunichi Takeda, Martin F Lavin, Jörg Heierhorst
Publikováno v: PLoS Genetics, Vol 6, Iss 10, p e1001170 (2010)
Zn²(+)-finger proteins comprise one of the largest protein superfamilies with diverse biological functions. The ATM substrate Chk2-interacting Zn²(+)-finger protein (ASCIZ; also known as ATMIN and ZNF822) was originally linked to functions in the D
Externí odkaz: https://doaj.org/article/62c0c42293aa43a988eb120276761f95
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