Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Ian, Sabroe"'
Autor:
Rebecca Dowey, Joby Cole, A.A. Roger Thompson, Rebecca C. Hull, Chenghao Huang, Jacob Whatmore, Ahmed Iqbal, Kirsty L. Bradley, Joanne McKenzie, Allan Lawrie, Alison M. Condliffe, Endre Kiss-Toth, Ian Sabroe, Lynne R. Prince
Publikováno v:
ERJ Open Research, Vol 8, Iss 2 (2022)
Background Neutrophil extracellular traps (NETs) are web-like DNA and protein lattices which are expelled by neutrophils to trap and kill pathogens, but which cause significant damage to the host tissue. NETs have emerged as critical mediators of lun
Externí odkaz:
https://doaj.org/article/939c2b6703794211b009663901e36f25
Autor:
Gregg H. Rawlings, Nigel Beail, Robin Condliffe, David G. Kiely, Andrew R. Thompson, Ian Sabroe, Iain Armstrong
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Pulmonary hypertension (PH) is a heterogeneous condition, associated with a high symptom burden and high rates of disability. While nonprofessional caregivers are essential in helping patients live better, little is known about the impact on
Externí odkaz:
https://doaj.org/article/2784f1d6e30c404c99bd6b66adb9fedf
Autor:
Mikaela Wardle, Amanda Nair, Sarah Saunders, Iain Armstrong, Athanasios Charalampopoulos, Charlie Elliot, Abdul Hameed, Neil Hamilton, John Harrington, Carol Keen, Robert Lewis, Ian Sabroe, A. A. Roger Thompson, Robert M. Kerry, Robin Condliffe, David G. Kiely
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH) are at increased risk when undergoing anesthesia and major surgery. Data on outcomes for elective orthopedic surgery in patients with PH are
Externí odkaz:
https://doaj.org/article/1bc01e214f354edcbe48fc18519b6699
Autor:
Grace T. Mussell, Helen Marshall, Laurie J. Smith, Alberto M. Biancardi, Paul J.C. Hughes, David J. Capener, Jody Bray, Andrew J. Swift, Smitha Rajaram, Alison M. Condliffe, Guilhem J. Collier, Chris S. Johns, Nick D. Weatherley, Jim M. Wild, Ian Sabroe
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Background Hyperpolarised gas magnetic resonance imaging (MRI) can be used to assess ventilation patterns. Previous studies have shown the image-derived metric of ventilation defect per cent (VDP) to correlate with forced expiratory volume in 1 s (FE
Externí odkaz:
https://doaj.org/article/76f201e4540b4befb2a85a5fe0ecf66c
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Ne
Externí odkaz:
https://doaj.org/article/de5da14c8a24478db0f8b21ff82f8ba0
Autor:
Kris Bauchmuller, Robin Condliffe, Jennifer Southern, Catherine Billings, Athanasios Charalampopoulos, Charlie A. Elliot, Abdul Hameed, David G. Kiely, Ian Sabroe, A.A. Roger Thompson, Ajay Raithatha, Gary H. Mills
Publikováno v:
ERJ Open Research, Vol 7, Iss 2 (2021)
Pulmonary hypertension (PH) is a life-shortening condition characterised by episodes of decompensation precipitated by factors such as disease progression, arrhythmias and sepsis. Surgery and pregnancy also place additional strain on the right ventri
Externí odkaz:
https://doaj.org/article/c41ee9e56e4c402780f1b82b91f1a2f0
Autor:
David G Kiely, Iain Armstrong, Robin Condliffe, Gregg Harry Rawlings, Nigel Beail, Ian Sabroe, Andrew R Thompson
Publikováno v:
BMJ Open, Vol 10, Iss 12 (2020)
Objectives Pulmonary hypertension is a life-shortening disease that has a considerable impact on quality of life. Improving our understanding of how individuals are affected and cope with the disease will help to improve services and outcomes. This r
Externí odkaz:
https://doaj.org/article/033b1be41dac4371bbc6119a1aa1c1e8
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Background: Despite affecting 15% of new mothers, experience of postnatal depression has often been hidden by stigma, cultural beliefs, and lack of medical understanding. We examined the barriers to women sharing their experience and gaining help, us
Externí odkaz:
https://doaj.org/article/d365ee1fdfe64c22871a22e4804a3fec
Autor:
Elizabeth K. Marsh, Elizabeth C. Prestwich, Lynne Williams, Amber R. Hart, Clare F. Muir, Lisa C. Parker, Marnix R. Jonker, Irene H. Heijink, Wim Timens, Mark Fife, Tracy Hussell, Marc B. Hershenson, J. Kelley Bentley, Shao-Cong Sun, Ben S. Barksby, Lee A. Borthwick, James P. Stewart, Ian Sabroe, David H. Dockrell, Helen M. Marriott
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to
Externí odkaz:
https://doaj.org/article/c5942d2d51cf4be9955c03b1925a6bc9
Autor:
Atiqur Rahman, Katherine M Henry, Kimberly D Herman, Alfred AR Thompson, Hannah M Isles, Claudia Tulotta, David Sammut, Julien JY Rougeot, Nika Khoshaein, Abigail E Reese, Kathryn Higgins, Caroline Tabor, Ian Sabroe, William J Zuercher, Caroline O Savage, Annemarie H Meijer, Moira KB Whyte, David H Dockrell, Stephen A Renshaw, Lynne R Prince
Publikováno v:
eLife, Vol 8 (2019)
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me
Externí odkaz:
https://doaj.org/article/fe7fcfe76891424e9fe5d095f6489f95