Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

Autor: Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland, Simon J. G. Lewis, the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area - Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)

Publikováno v: Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)

Abstract The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit i

Externí odkaz: https://doaj.org/article/6058a154f53c4fd0b938c4c0b34ec507

Improving the diagnosis and management of Lewy body dementia: the DIAMOND-Lewy research programme including pilot cluster RCT

Autor: John T O’Brien, John-Paul Taylor, Alan Thomas, Claire Bamford, Luke Vale, Sarah Hill, Louise Allan, Tracy Finch, Richard McNally, Louise Hayes, Ajenthan Surendranathan, Joseph Kane, Alexandros E Chrysos, Allison Bentley, Sally Barker, James Mason, David Burn, Ian McKeith

Publikováno v: Programme Grants for Applied Research, Vol 9, Iss 7 (2021)

Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is the second commonest cause of neurodegenerative dementia. Existing evidence suggests that it is underdiagnosed and without a consistent a

Externí odkaz: https://doaj.org/article/babfa2016f3142709c81cde594a967e9

Correction: Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

Autor: Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland, Simon J. G. Lewis, the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area - Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)

Publikováno v: Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/35c0f8e869484f1cb49f4fb1335b03d4

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Autor: Simona S. Ghanem, Nour K. Majbour, Nishant N. Vaikath, Mustafa T. Ardah, Daniel Erskine, Nanna Møller Jensen, Muneera Fayyad, Indulekha P. Sudhakaran, Eftychia Vasili, Katerina Melachroinou, Ilham Y. Abdi, Ilaria Poggiolini, Patricia Santos, Anton Dorn, Paolo Carloni, Kostas Vekrellis, Johannes Attems, Ian McKeith, Tiago F. Outeiro, Poul Henning Jensen, Omar M. A. El-Agnaf

Publikováno v: Ghanem, S S, Majbour, N K, Vaikath, N N, Ardah, M T, Erskine, D, Jensen, N M, Fayyad, M, Sudhakaran, I P, Vasili, E, Melachroinou, K, Abdi, I Y, Poggiolini, I, Santos, P, Dorn, A, Carloni, P, Vekrellis, K, Attems, J, McKeith, I, Outeiro, T F, Jensen, P H & El-Agnaf, O M A 2022, ' α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity ', PNAS (Proceedings of the National Academy of Sciences of the United States of America), vol. 119, no. 15, e2109617119 . https://doi.org/10.1073/pnas.2109617119
Proceedings of the National Academy of Sciences of the United States of America 119(15), e2109617119 (2022). doi:10.1073/pnas.2109617119

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the pathogenic relevance of pS129–α-syn remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba55d29b3d2b2ef5284fe1134f6d0e19
https://doi.org/10.1073/pnas.2109617119

Poor Reactivity of Posterior Electroencephalographic Alpha Rhythms During the Eyes Open Condition in Patients with Dementia Due to Parkinson’s Disease

Autor: Claudio Babiloni, Giuseppe Noce, Federico Tucci, Raffaele Ferri, Simonetta Panerai, Valentina Catania, Andrea Soricelli, Marco Salvatore, Flavio Nobili, Dario Arnaldi, Francesco Famà, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Fabiana Radicati, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucilla Parnetti, Moira Marizzoni, Fabrizia D'Antonio, Giuseppe Bruno, Carlo De Lena, Bahar Güntekin, Ebru Yıldırım, Luftu Hanoglu, Görsev Yener, Duygu Hünerli Gündüz, John Paul Taylor, Julia Schumacher, Ian McKeith, Giovanni Frisoni, Angelo Antonini, Florinda Ferreri, Laura Bonanni, Maria Francesca De Pandis, Claudio Del Percio

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ff8b503f0c4862a716e18d0028ff324
https://doi.org/10.2139/ssrn.4163963