Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Ian, Dransfield"'
Autor:
Utsa Karmakar, Julia Y. Chu, Kruthika Sundaram, Anne L. Astier, Hannah Garside, Carsten G. Hansen, Ian Dransfield, Sonja Vermeren
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Abstract Persistent neutrophilic inflammation drives host damage in autoimmune diseases that are characterized by abundant immune complexes. Insoluble immune complexes (iICs) potently activate pro-inflammatory neutrophil effector functions. We and ot
Externí odkaz:
https://doaj.org/article/b1787cc0631143feb3407852a0bf8d83
Autor:
Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield, Marc Vendrell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imag
Externí odkaz:
https://doaj.org/article/7e4b972f90a04057803fb05db7c472e8
Autor:
Sarah Farnworth-McHugh, Nicole Barth, Lynsey Melville, Margaret Paterson, Catherine Lynch, Pamela Holland, Ian Dransfield, Christopher Gregory
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The histological architecture of certain aggressive B-cell lymphomas (prototypically Burkitt's lymphoma, BL) is characterized by a “starry-sky” (SS) appearance. This is caused by tumor-associated macrophages (TAMs), which appear in standard histo
Externí odkaz:
https://doaj.org/article/8dbc672b62f6416aa4566537282e168c
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Programmed cell death (apoptosis) has an important role in the maintenance of tissue homeostasis as well as the progression and ultimate resolution of inflammation. During apoptosis, the cell undergoes morphological and biochemical changes [e.g., pho
Externí odkaz:
https://doaj.org/article/53504da5ef244400bed52301211528d6
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 374-386 (2016)
Neutrophils are peripheral blood leukocytes that represent the first line of immune cell defense against bacterial and fungal infections but are also crucial players in the generation of the inflammatory response. Many neutrophil cell surface recepto
Externí odkaz:
https://doaj.org/article/82d67d764e3645259443a11ab17d6ae9
Autor:
Ross Mills, Abhinav Mathur, Lisa M. Nicol, Jeremy J. Walker, Alexander A. Przybylski, Alison C. Mackinnon, Sarah E. M. Howie, William A. H. Wallace, Ian Dransfield, Nik Hirani
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Rationale. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease, with high mortality. Currently, the aetiology and the pathology of IPF are poorly understood, with both innate and adaptive responses previously being
Externí odkaz:
https://doaj.org/article/0241ff1a83974837a23d9b0c6e231060
Autor:
Christopher D. Gregory, Ian Dransfield
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cells undergoing apoptosis produce heterogeneous populations of membrane delimited extracellular vesicles (Apo-EVs) which vary not only in size—from tens of nanometers to several microns—but also in molecular composition and cargo. Apo-EVs carry
Externí odkaz:
https://doaj.org/article/17380b9d65904f59a2c77d8e06e834f7
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Apoptosis and subsequent phagocytic clearance of apoptotic cells is important for embryonic development, maintenance of tissues that require regular cellular renewal and innate immunity. The timely removal of apoptotic cells prevents progression to s
Externí odkaz:
https://doaj.org/article/b35dc250df3a482ca069bbc8835ef4f0
Autor:
Robert D. Gray, Ian Dransfield, Colin Campbell, Samuel J. Stanfield, Gareth Hardisty, Sheonagh M. Law
Publikováno v:
Law, S M, Stanfield, S J, Hardisty, G R, Dransfield, I, Campbell, C J & Gray, R D 2019, ' Human cystic fibrosis monocyte derived macrophages display no defect in acidification of phagolysosomes when measured by optical nanosensors ', Journal of Cystic Fibrosis . https://doi.org/10.1016/j.jcf.2019.09.003
BACKGROUND: Defective macrophage phagolysosomal acidification is implicated in numerous lung diseases including Cystic Fibrosis (CF) and may contribute to defective pathogen killing. Conflicting reports relating to phagolysosomal pH in CF macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5a9ea56a2e73c7814876a3363d3f0e
https://doi.org/10.1016/j.jcf.2019.09.003
https://doi.org/10.1016/j.jcf.2019.09.003
Autor:
Simon B. Brown, Ian Dransfield
Publikováno v:
The Scientific World Journal, Vol 8, Pp 1280-1294 (2008)
Integrins are a family of ubiquitous cell surface receptors comprising heterodimers of β and α chains that are required for cell adhesion and motility. Integrin-dependent adhesion and signaling is associated with major conformational changes in the
Externí odkaz:
https://doaj.org/article/752e5c538abc4aaaa6ed457888ed559a