Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Iain W, Manfield"'
Autor:
Bob Schiffrin, Joel A. Crossley, Martin Walko, Jonathan M. Machin, G. Nasir Khan, Iain W. Manfield, Andrew J. Wilson, David J. Brockwell, Tomas Fessl, Antonio N. Calabrese, Sheena E. Radford, Anastasia Zhuravleva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ATP-independent chaperone SurA protects unfolded outer membrane proteins (OMPs) from aggregation in the periplasm of Gram-negative bacteria, and delivers them to the β-barrel assembly machinery (BAM) for folding into the outer membrane
Externí odkaz:
https://doaj.org/article/b8ce23fd6b774989b970d0af57f9265e
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors carry out chemical kinetic studies revealing that aggregation of hIAPP and its variant S20G involves secondary nucleation. Two small molecules with novel scaffolds are shown to inhibit or accelerate aggregation by binding different m
Externí odkaz:
https://doaj.org/article/d21098cc865040188a3674711bd2d77e
Autor:
Fardokht Abulwerdi, Farzad Fatehi, Iain W. Manfield, Stuart F.J. Le Grice, John S. Schneekloth, Reidun Twarock, Peter G. Stockley, Nikesh Patel
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108206- (2022)
Multiple ssRNA viruses which infect bacteria, plants or humans use RNA Packaging Signal (PS)-mediated regulation during assembly to package their genomes faithfully and efficiently. PSs typically comprise short nucleotide recognition motifs, most oft
Externí odkaz:
https://doaj.org/article/1f4a24cc33804de5b1e26862f06ae21e
Autor:
Cédric Duval, Robert A. S. Ariëns, Rui-Gang Xu, Helen R. McPherson, Iain W. Manfield, Alexandre Slater, Steve P. Watson, Stephen R. Baker, Julia S. Gauer, Eleyna M. Martin, Arkadiusz Bonna
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet signaling and aggregation. Recent evidence indicates that it also plays important role in platelet ag
Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet signaling and aggregation. Recent evidence indicates that it also plays important role in platelet ag
Autor:
Holly Foster, Clare Wilson, Julia S. Gauer, Rui-Gang Xu, Mark J. Howard, Iain W. Manfield, Robert Ariëns, Khalid Naseem, Lewis R. Vidler, Helen Philippou, Richard Foster
Publikováno v:
ACS Med Chem Lett
[Image: see text] The GPVI platelet receptor was recently validated as a safe antiplatelet target for the treatment of thrombosis using several peptidic modulators. In contrast, few weakly potent small-molecule GPVI antagonists have been reported. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2531592f1cfe91a9cc6e553d7f4e4b
https://europepmc.org/articles/PMC8842102/
https://europepmc.org/articles/PMC8842102/
Autor:
Fatima Nadat, Chris F. Inglehearn, Laura Wilkinson Hewitt, Alan J. Mighell, Claire E. L. Smith, Helen D. Rodd, James A. Poulter, Laura L. E. Whitehouse, Thomas A. Edwards, Brian R. Jackson, Iain W. Manfield
Publikováno v:
Human Molecular Genetics
Amelogenesis is the process of enamel formation. For amelogenesis to proceed, the cells of the inner enamel epithelium (IEE) must first proliferate and then differentiate into the enamel-producing ameloblasts. Amelogenesis imperfecta (AI) is a hetero
Autor:
Farzad Fatehi, Reidun Twarock, Nikesh Patel, John S. Schneekloth, S.F.J. Le Grice, Fardokht A. Abulwerdi, Peter G. Stockley, Iain W. Manfield
RNA sequences/motifs dispersed across the pre-genomic copy of the Hepatitis B Virus genome regulate formation of nucleocapsidsin vitroin an epsilon/polymerase independent fashion. These multiple RNA Packaging Signals (PSs) form stem-loops presenting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca3569fef2c786420d695fc1fc5f5239
https://doi.org/10.1101/2021.08.10.455820
https://doi.org/10.1101/2021.08.10.455820
Autor:
Yong, Xu, Roberto, Maya-Martinez, Nicolas, Guthertz, George R, Heath, Iain W, Manfield, Alexander L, Breeze, Frank, Sobott, Richard, Foster, Sheena E, Radford
Publikováno v:
Nature communications. 13(1)
Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP and its