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of 4
pro vyhledávání: '"Iain T. Strickland"'
Autor:
Iain T Strickland, Louise Richards, Fiona E Holmes, David Wynick, James B Uney, Liang-Fong Wong
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23423 (2011)
Following injury, dorsal root ganglion (DRG) neurons undergo transcriptional changes so as to adopt phenotypic changes that promote cell survival and axonal regeneration. Here we used a microarray approach to profile changes in a population of small
Externí odkaz:
https://doaj.org/article/2bdd339e37c14dd6ac0b92a241ba6ed7
Autor:
Ian Blount, G. Scott Ralph, Kyriacos A. Mitrophanous, Stéphane Palfi, Laura McCloskey, Alan J. Kingsman, Owen Wells, Christelle J M Truran, Lucy Barnes, Liang Fong-Wong, Iain T. Strickland, Hannah J Stewart
Publikováno v:
Human gene therapy. Clinical development. 27(3)
Pharmacological dopamine replacement therapies provide the most well-established treatments for Parkinson's disease (PD). However, these long-term treatments can lead to motor complications and off-target effects. ProSavin(®), a lentiviral vector (L
Autor:
Liang Fong-Wong, G. Scott Ralph, Vinay Thoree, Michelle Kelleher, Iain T. Strickland, Kyriacos A. Mitrophanous, Hannah J Stewart, Pippa A Radcliffe, Laura Stevenson, Janine McCarthy, Daniel Chipchase
Publikováno v:
Human Gene Therapy. 22:357-369
ProSavin is an equine infectious anemia virus vector-based gene therapy for Parkinson's disease for which inducible HEK293T-based producer cell lines (PCLs) have been developed. These cell lines demonstrate stringent tetracycline-regulated expression
Autor:
Daniel S. McQueen, Alison J Reeve, Susan M. Bond, Iain P. Chessell, Simon T. Bate, Iain T. Strickland, Nicola J. Barton, Harry M. Brash, Alex W. Wilson
Publikováno v:
Journal of neuroscience methods. 163(1)
Chronic joint pain affects physical well being and can lead to severe psychological and social problems, therefore successful long-term management is highly sought-after. No current behavioural measures of pain used in pre-clinical models mimic the c