Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Iain S. MacPherson"'
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aptamers are oligonucleotides with antibody-like binding function, selected from large combinatorial libraries. In this study, we modified a DNA aptamer library with N-hydroxysuccinimide esters, enabling covalent conjugation with cognate pro
Externí odkaz:
https://doaj.org/article/c6e03b0bd137452a887b6528adc87737
Autor:
Samet Kocabey, Hanna Meinl, Iain S. MacPherson, Valentina Cassinelli, Antonio Manetto, Simon Rothenfusser, Tim Liedl, Felix S. Lichtenegger
Publikováno v:
Nanomaterials, Vol 5, Iss 1, Pp 47-60 (2014)
DNA-based nanostructures have received great attention as molecular vehicles for cellular delivery of biomolecules and cancer drugs. Here, we report on the cellular uptake of tubule-like DNA tile-assembled nanostructures 27 nm in length and 8 nm in d
Externí odkaz:
https://doaj.org/article/785176cf632d47f0810449ae285925c5
Autor:
Donghong Min, Helen R Josephine, Hongzhi Li, Clemens Lakner, Iain S MacPherson, Gavin J P Naylor, David Swofford, Lizbeth Hedstrom, Wei Yang
Publikováno v:
PLoS Biology, Vol 6, Iss 8, p e206 (2008)
Inosine monophosphate dehydrogenase (IMPDH) catalyzes an essential step in the biosynthesis of guanine nucleotides. This reaction involves two different chemical transformations, an NAD-linked redox reaction and a hydrolase reaction, that utilize mut
Externí odkaz:
https://doaj.org/article/ddb9bd56b4474bdcb042295fdd6460ad
Autor:
Tim Liedl, Simon Rothenfusser, Samet Kocabey, Antonio Manetto, Felix S. Lichtenegger, Iain S. MacPherson, Valentina Cassinelli, Hanna Meinl
Publikováno v:
Nanomaterials, Vol 5, Iss 1, Pp 47-60 (2014)
Nanomaterials
Volume 5
Issue 1
Pages 47-60
Nanomaterials
Volume 5
Issue 1
Pages 47-60
DNA-based nanostructures have received great attention as molecular vehicles for cellular delivery of biomolecules and cancer drugs. Here, we report on the cellular uptake of tubule-like DNA tile-assembled nanostructures 27 nm in length and 8 nm in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab32279b8237ce56d9d7652ccdb29c9f
https://doi.org/10.3390/nano5010047
https://doi.org/10.3390/nano5010047
Publikováno v:
Nature Chemical Biology. 10:990-999
Although efforts to develop a vaccine against HIV have so far met with little success, recent studies of HIV-positive patients with strongly neutralizing sera have shown that the human immune system is capable of producing potent and broadly-neutrali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fb647f6d979b7085137b0522902542
https://doi.org/10.1038/nchembio.1685
https://doi.org/10.1038/nchembio.1685
Autor:
Lizbeth Hedstrom, Sivapriya Kirubakaran, Minjia Zhang, Iain S. MacPherson, Xiaoping Liu, Gregory D. Cuny, Suresh Kumar Gorla, Lisa Sharling, Soumya S. Ray, Boris Striepen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1985-1988
Cryptosporidium parasites are important waterborne pathogens of both humans and animals. The Cryptosporidium parvum and Cryptosporidium hominis genomes indicate that the only route to guanine nucleotides is via inosine 5'-monophosphate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e42b13e659767a7c383a160377effe
https://doi.org/10.1016/j.bmcl.2012.01.029
https://doi.org/10.1016/j.bmcl.2012.01.029
Autor:
Sevan Habeshian, J. Sebastian Temme, Isaac J. Krauss, Iain S. MacPherson, Krzysztof W. Pankiewicz, Krzysztof Felczak, Lizbeth Hedstrom
Publikováno v:
Angewandte Chemie. 123:11434-11438
A vast number of biological processes are mediated by multivalent ligand-receptor interactions, including cell adhesion, host invasion by pathogens, pathogen neutralization by host and numerous cell regulatory signaling pathways.[1] Multivalency is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11534b29b1b69c0388cce38e8c200fe6
https://doi.org/10.1002/ange.201105555
https://doi.org/10.1002/ange.201105555
Autor:
Lizbeth Hedstrom, Joanna B. Goldberg, Suresh Kumar Gorla, Deviprasad R. Gollapalli, George W. Liechti, Iain S. MacPherson
Publikováno v:
Chemistry & Biology. 17:1084-1091
The protozoan parasite Cryptosporidium parvum is a major cause of gastrointestinal disease; no effective drug therapy exists to treat this infection. Curiously, C. parvum IMPDH (CpIMPDH) is most closely related to prokaryotic IMPDHs, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2999e28fb70382e64c5befbb9b6e938
https://doi.org/10.1016/j.chembiol.2010.07.014
https://doi.org/10.1016/j.chembiol.2010.07.014
Autor:
Michael E. P. Murphy, Iain S. MacPherson, Federico I. Rosell, Melanie Scofield, A. Grant Mauk
Publikováno v:
Protein Engineering Design and Selection. 23:137-145
Directed evolution methods were developed for Cu-containing nitrite reductase (NiR) from Alcaligenes faecalis S-6. The PCR cloning strategy allows for the efficient production of libraries of 100 000 clones by a modification of a megaprimer-based who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f8c94ca89274a79fdcd4b1e0529e0f
https://doi.org/10.1093/protein/gzp084
https://doi.org/10.1093/protein/gzp084
Autor:
Gerard W. Canters, Michael E. P. Murphy, Maxime Alexandre, Martin Ph. Verbeet, Rutger E. M. Diederix, Iain S. MacPherson, Hein J. Wijma
Publikováno v:
Journal of Molecular Biology, 358(4), 1081-1093. Academic Press
In Cu-containing nitrite reductase from Alcaligenes faecalis S-6 the axial methionine ligand of the type-1 site was replaced (M150G) to make the copper ion accessible to external ligands that might affect the enzyme's catalytic activity. The type-1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18a25c02a2ed8be9ae0173cf7052318
https://doi.org/10.1016/j.jmb.2006.02.042
https://doi.org/10.1016/j.jmb.2006.02.042