Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Iain Robert Gladwell"'
Autor:
Matthew Badland, Roger M. Howard, Steven J. Fussell, Robert Walton, Gerald A. Weisenburger, Bastien Delayre, Iain Robert Gladwell, Michael Hawksworth, Robert Crook
Publikováno v:
Tetrahedron Letters. 58:4391-4394
A survey of amidation reagents demonstrating DIC-HOPO, DMT-MM, COMU-collidine, TPTU-NMI, EEDQ, CDI and EDC-Oxyma to be effective for the coupling of carboxylic acids with amines in the presence of water and the absence of problematic dipolar aprotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2c23889f736cc9b056d154aea3a1d37
https://doi.org/10.1016/j.tetlet.2017.10.014
https://doi.org/10.1016/j.tetlet.2017.10.014
Autor:
Alan John Pettman, Nieves Castro, Iain Robert Gladwell, Ian B. Moses, Natalie A. Morrison, Maninder S. Panesar, Nicholas Murray Thomson, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1256-1265
The development of a practical, scalable route to PF-00610355 (8) is described. In this convergent approach, amine 9 is coupled to protected bromohydrin 1 to give the doubly protected intermediate 26. TBS-Deprotection of 26 affords the benzyl protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1470e98fe2368ffa01e135a9a795b4
https://doi.org/10.1021/op2002408
https://doi.org/10.1021/op2002408
Autor:
Iain Robert Gladwell, Ian B. Moses, Nicholas Murray Thomson, Maninder S. Panesar, Alan John Pettman, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1247-1255
The initial route used to prepare PF-00610355 (8) for early clinical development is described. Through careful choice of solvent, an efficient, telescoped route to carboxylic acid 23 was developed, affording this late-stage intermediate in 80% yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef178697153d9bcbc018eee494d246fc
https://doi.org/10.1021/op2001904
https://doi.org/10.1021/op2001904
Autor:
Alan John Pettman, Daniel R. Yazbeck, Maninder S. Panesar, Nicholas Murray Thomson, Ian B. Moses, Iain Robert Gladwell, Pieter D. de Koning, Natalie A. Morrison
Publikováno v:
Organic Process Research & Development. 15:871-875
An efficient process to ethyl [3-(2-amino-2-methylpropyl)phenyl]acetate 6 has been developed. Key steps include a novel enzymatic desymmetrization of diester 2 and a Ritter reaction between alcohol...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae29c37bee97d64db0912c91bafab7b
https://doi.org/10.1021/op200108k
https://doi.org/10.1021/op200108k