Breath and plasma metabolomics to assess inflammation in acute stroke

Autor: Waqar Ahmed, Iain R. White, Maxim Wilkinson, Craig F. Johnson, Nicholas Rattray, Amit K. Kishore, Royston Goodacre, Craig J. Smith, Stephen J. Fowler

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted meta

Externí odkaz: https://doaj.org/article/263bc1bb366f407493f151fb380588c1

Microbial Volatiles as Diagnostic Biomarkers of Bacterial Lung Infection in Mechanically Ventilated Patients

Autor: Waqar M, Ahmed, Dominic, Fenn, Iain R, White, Breanna, Dixon, Tamara M E, Nijsen, Hugo H, Knobel, Paul, Brinkman, Pouline M P, Van Oort, Marcus J, Schultz, Paul, Dark, Royston, Goodacre, Timothy, Felton, Lieuwe D J, Bos, Stephen J, Fowler

Publikováno v: BreathDx Consortium 2023, ' Microbial Volatiles as Diagnostic Biomarkers of Bacterial Lung Infection in Mechanically Ventilated Patients ', Clinical Infectious Diseases, vol. 76, no. 6, pp. 1059-1066 . https://doi.org/10.1093/cid/ciac859
BreathDx Consortium, Ahmed, W M, Dark, P, Felton, T, Fowler, S J & Dixon, B 2022, ' Microbial volatiles as diagnostic biomarkers of bacterial lung infection in mechanically ventilated patients ', Clinical infectious diseases . https://doi.org/10.1093/cid/ciac859

Background Early and accurate recognition of respiratory pathogens is crucial to prevent increased risk of mortality in critically ill patients. Microbial-derived volatile organic compounds (mVOCs) in exhaled breath could be used as noninvasive bioma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3cef6dc182a46a6d18165e98b7cc1f
https://research.vumc.nl/en/publications/3785b964-3830-4d89-b750-da687c1f0a91

Breath and plasma metabolomics to assess inflammation in acute stroke

Autor: Royston Goodacre, Iain R. White, Craig J. Smith, Craig F. Johnson, Maxim Wilkinson, Nicholas J. W. Rattray, Stephen J. Fowler, Waqar Ahmed, Amit Kishore

Publikováno v: Scientific Reports
Ahmed, W, White, I R, Wilkinson, M, Johnson, C F, Rattray, N, Kishore, A K, Goodacre, R, Smith, C J & Fowler, S J 2021, ' Breath and plasma metabolomics to assess inflammation in acute stroke ', Scientific Reports, vol. 11, no. 1, 21949 . https://doi.org/10.1038/s41598-021-01268-5
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3984d468f35d81a0c13ef7439360d62
https://strathprints.strath.ac.uk/80013/1/Ahmed_etal_SR_2021_Breath_and_plasma_metabolomics_to_assess_inflammation_in_acute_stroke.pdf

Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients-comparison of two sampling methods

Autor: Iain R. White, Jonathan Bannard-Smith, Waqar Ahmed, Craig F. Johnson, Stephen J. Fowler, Pouline M.P. van Oort, Timothy Felton, Royston Goodacre, Lieuwe D. J. Bos, Paul Dark

Publikováno v: Analyst, 146(1), 222-231. Royal Society of Chemistry
van Oort, P M P, White, I R, Ahmed, W, Johnson, C, Bannard-Smith, J, Felton, T, Bos, L D, Goodacre, R, Dark, P & Fowler, S J 2021, ' Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients-comparison of two sampling methods ', Analyst, vol. 146, no. 1, pp. 222-231 . https://doi.org/10.1039/c9an01134j
van, O PMP, White, IR, Ahmed, W, Johnson, C, Bannard-Smith, J, Felton, T, Bos, LD, Goodacre, R, Dark, P & Fowler, SJ 2020, ' Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients-comparison of two sampling methods. ', The Analyst . https://doi.org/10.1039/c9an01134j
Oort, P M P V, White, I R, Ahmed, W, Johnson, C, Bannard-Smith, J, Felton, T, Bos, L D, Goodacre, R, Dark, P & Fowler, S J 2021, ' Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients : comparison of two sampling methods ', The Analyst, vol. 146, no. 1, pp. 222-231 . https://doi.org/10.1039/C9AN01134J

Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We compared two breath sampling methods, first using an artificial ventilator circuit, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4772d11a9f2f7cace882e728b5784b
https://research.vumc.nl/en/publications/c2e479c5-cfca-41ed-8220-e629cb933880

Understanding antimicrobial prescribing in suspected ventilator-associated pneumonia: a prospective cohort study

Autor: Yun Xu, Callum Docherty, Stephen A Roberts, Roy Goodacre, Ingeborg Walters, Ben Morton, Stephen J. Fowler, Jonathan Bannard-Smith, Paul Dark, Timothy Felton, Ronan McMullan, Iain R White

Publikováno v: Access Microbiology. 2

Background Ventilator-associated pneumonia (VAP) is associated with significant healthcare cost, morbidity, and mortality, but can be difficult to identify, resulting in over-diagnosis and excessive use of broad-spectrum antimicrobial therapy. In add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad8d68f9ee403a09d02afc0893a9c812
https://doi.org/10.1099/acmi.fis2019.po0041