Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Iain R. Greig"'
Autor:
Thabat Khatib, Pietro Marini, Sudheer Nunna, David R. Chisholm, Andrew Whiting, Christopher Redfern, Iain R. Greig, Peter McCaffery
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional activity via RA receptors (RARs) a
Externí odkaz:
https://doaj.org/article/330b2674541e4c07a9ef2d9a22ca6c3a
Autor:
Hayley M. Green, David B. Finlay, Ruth A. Ross, Iain R. Greig, Stephen B. Duffull, Michelle Glass
Publikováno v:
ACS Pharmacology & Translational Science. 5:1279-1291
Autor:
Victoria Gorberg, Veronika Borisov, Iain R. Greig, Roger G. Pertwee, Peter McCaffery, Sharon Anavi-Goffer
Publikováno v:
Molecular Neurobiology. 59:5070-5083
Δ9-Tetrahydrocannabinol (Δ9-THC) inhibits tics in individuals with Tourette syndrome (TS). Δ9-THC has similar affinities for CB1/CB2 cannabinoid receptors. However, the effect of HU-308, a selective CB2 receptor agonist, on repetitive behaviors ha
Autor:
Mina G. Nashed, Shannon Waye, S. M. Nageeb Hasan, Diana Nguyen, Micaela Wiseman, Jing Zhang, Harry Lau, O. Chandani Dinesh, Roger Raymond, Iain R. Greig, Francis Rodriguez Bambico, José N. Nobrega
Publikováno v:
Psychopharmacology. 239:253-266
Autor:
Amy J. Ramsey, Nirunthan Sivananthan, Matthieu Schapira, W. McIntyre Burnham, Vincent M. Lam, Mostafa H. Abdelrahman, Sean Harrington, David B. Finlay, Ruth A. Ross, Jibran Y. Khokhar, Chun Kit Li, Laurent Trembleau, Iain R. Greig, Ali Salahpour, Kim S. Sugamori, Catharine A. Mielnik, Michelle Glass, Hayley H. A. Thorpe
Publikováno v:
Neuropsychopharmacology
The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system. Many aspects
Autor:
Victoria, Gorberg, Veronika, Borisov, Iain R, Greig, Roger G, Pertwee, Peter, McCaffery, Sharon, Anavi-Goffer
Publikováno v:
Molecular neurobiology. 59(8)
Δ
Autor:
Mina G, Nashed, Shannon, Waye, S M Nageeb, Hasan, Diana, Nguyen, Micaela, Wiseman, Jing, Zhang, Harry, Lau, O Chandani, Dinesh, Roger, Raymond, Iain R, Greig, Francis Rodriguez, Bambico, José N, Nobrega
Publikováno v:
Psychopharmacology. 239(1)
The voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is implicated in the pathophysiology of depressive disorders.We ascertained whether the SK channel is impaired in th
Autor:
Matteo Zanda, Sergio Dall'Angelo, Giulia Donvito, Aron H. Lichtman, Chiara Zanato, Iain R. Greig, Sophie E. Juola, Mohammed A. Mustafa, Ruth A. Ross, Gemma L. Baillie, Chih-Chung Tseng, William T. A. Harrison, Chiara Massarenti
Publikováno v:
J Med Chem
Journal of medicinal chemistry 62 (2019): 5049–5062. doi:10.1021/acs.jmedchem.9b00252
info:cnr-pdr/source/autori:Tseng C.-C.; Baillie G.; Donvito G.; Mustafa M.A.; Juola S.E.; Zanato C.; Massarenti C.; Dall'Angelo S.; Harrison W.T.A.; Lichtman A.H.; Ross R.A.; Zanda M.; Greig I.R./titolo:The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators/doi:10.1021%2Facs.jmedchem.9b00252/rivista:Journal of medicinal chemistry/anno:2019/pagina_da:5049/pagina_a:5062/intervallo_pagine:5049–5062/volume:62
Journal of medicinal chemistry 62 (2019): 5049–5062. doi:10.1021/acs.jmedchem.9b00252
info:cnr-pdr/source/autori:Tseng C.-C.; Baillie G.; Donvito G.; Mustafa M.A.; Juola S.E.; Zanato C.; Massarenti C.; Dall'Angelo S.; Harrison W.T.A.; Lichtman A.H.; Ross R.A.; Zanda M.; Greig I.R./titolo:The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators/doi:10.1021%2Facs.jmedchem.9b00252/rivista:Journal of medicinal chemistry/anno:2019/pagina_da:5049/pagina_a:5062/intervallo_pagine:5049–5062/volume:62
The first generation of CB(1) positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs include the nitro group, it is generally not regarded as being “drug-like”, and this i
Autor:
Weiming Mao, Alex Straiker, Sally Miller, Iain R. Greig, Ruth A. Ross, Naga Pradeep Rayana, Laura Daily, Chenna Kesavulu Sugali, Maya Ploss, Jiannong Dai
Publikováno v:
Exp Eye Res
The cannabinoid signaling system regulates intraocular pressure (IOP) in the mouse via a complex system that includes three receptors: CB1, GPR18 and GPR119. In each case, activating the receptor lowers IOP, but CB1 receptors are found both at sites
Publikováno v:
Biology of Reproduction
Low molecular weight heparin (LMWH) is being investigated as a potential preventative therapy against preeclampsia. There is evidence suggesting that LMWH may prevent preeclampsia through anticoagulation-independent mechanisms. In this study, we comp