Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Iain R. Challis"'
Autor:
Ming-Qiang Zhang, Barrie Wilkinson, Christine Martin, Matthew Alan Gregory, Chrisostomos Prodromou, Laurence H. Pearl, Isabelle Carletti, Iain R. Challis, Sabine Gaisser, S. Mark Roe, Susan M. Boyd
Publikováno v:
Journal of Medicinal Chemistry. 51:2853-2857
Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant diffe
Autor:
Iain R. Challis, Lindsey Low, Peter F. Leadlay, Rolf Müller, Barrie Wilkinson, Steven G. Kendrew, Jose Garcia-Bernardo, Hans-Jürgen Hecht, Hrvoje Petković, Axel Sandmann, Barbara Silakowski, Enej Kuščer, Nicola Beeston
Publikováno v:
Org. Biomol. Chem.. 6:500-506
The production of epothilone mixtures is a direct consequence of the substrate tolerance of the module 3 acyltransferase (AT) domain of the epothilone polyketide synthase (PKS) which utilises both malonyl- and methylmalonyl-CoA extender units. Partic
Autor:
Mark A. Freeman, Malcolm J. Mitchinson, Peter J. Kirkpatrick, Ian F. Dennis, Iain R. Challis, Peter L. Weissberg, Keri L.H. Carpenter
Publikováno v:
Free Radical Research. 37:1235-1244
Much experimental evidence suggests that lipid oxidation is important in atherogenesis and in epidemiological studies dietary antioxidants appear protective against cardiovascular events. However, most large clinical trials failed to demonstrate bene
Publikováno v:
Free Radical Research. 36:791-802
Epidemiologically, a high-carotenoid intake via a fruit- and vegetable-rich diet is associated with a decreased risk of various forms of cancer. The mechanisms by which carotenoids exert this protective effect are controversial. In this study, we exa
Autor:
Ian F. Dennis, Keri L.H. Carpenter, David S. Leake, Mark J. Arends, Malcolm J. Mitchinson, David Osborn, Colin H. Macphee, Iain R. Challis
Publikováno v:
Carpenter, K L, Dennis, I F, Challis, I R, Osborn, D P, Macphee, C H, Leake, D S, Arends, M J & Mitchinson, M J 2001, ' Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages ', FEBS Letters, vol. 505, no. 3, pp. 357-63 . https://doi.org/10.1016/S0014-5793(01)02840-X
The death of macrophages contributes to atheroma formation. Oxidation renders low-density lipoprotein (LDL) cytotoxic to human monocyte-macrophages. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also termed platelet-activating factor acetylhydro
Autor:
Barrie Wilkinson, Iain R. Challis, Hrvoje Petković, Rose Mary Sheridan, Enej Kuščer, Matthew Alan Gregory, Nigel Coates
Publikováno v:
Journal of bacteriology. 189(13)
Rapamycin is an important macrocyclic polyketide produced by Streptomyces hygroscopicus and showing immunosuppressive, antifungal, and antitumor activities as well as displaying anti-inflammatory and neuroregenerative properties. The immense pharmaco
Autor:
Rosamund McNair, Iain R. Challis, Nikki Figg, Catherine M. Shanahan, Peter L. Weissberg, Keri L.H. Carpenter, Diane Proudfoot, John D. Davies
Publikováno v:
The Journal of biological chemistry. 280(5)
Lipid accumulation by vascular smooth muscle cells (VSMC) is a feature of atherosclerotic plaques. In this study we describe two mechanisms whereby human VSMC foam cell formation is driven by de novo synthesis of fatty acids leading to triacylglycero
Autor:
Barrie Wilkinson, Hrvoje Petković, Iain R. Challis, Sarah J. Ready, Peter F. Leadlay, Isabelle Carletti, Michael Ward, Hui Hong, Alison J. Weston, Lindsey Low, Rose Mary Sheridan, Rachel E. Lill, Christine Martin, Sabine Gaisser, Matthew Alan Gregory, Andrew L. Kaja, Lesley S. Sheehan
Publikováno v:
Organic & Biomolecular Chemistry. 4:3565
The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.
Autor:
Iain R. Challis, Peter L. Weissberg, Catherine M. Shanahan, Nikki Figg, Keri L.H. Carpenter, John Davies
Publikováno v:
Cardiovascular Pathology. 13:27
Autor:
Christine J. Martin, Sabine Gaisser, Iain R. Challis, Isabelle Carletti, Barrie Wilkinson, Matthew Gregory, Chrisostomos Prodromou, S. Mark Roe, Laurence H. Pearl, Susan M. Boyd, Ming-Qiang Zhang
Publikováno v:
Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 9, p2853-2857, 5p