Molecular Characterization of Macbecin as an Hsp90 Inhibitor

Autor: Ming-Qiang Zhang, Barrie Wilkinson, Christine Martin, Matthew Alan Gregory, Chrisostomos Prodromou, Laurence H. Pearl, Isabelle Carletti, Iain R. Challis, Sabine Gaisser, S. Mark Roe, Susan M. Boyd

Publikováno v: Journal of Medicinal Chemistry. 51:2853-2857

Macbecin compares favorably to geldanamycin as an Hsp90 inhibitor, being more soluble, stable, more potently inhibiting ATPase activity (IC50 = 2 microM) and binding with higher affinity (Kd = 0.24 microM). Structural studies reveal significant diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa564049f5db144d4417cf5f6908455
https://doi.org/10.1021/jm701558c

Oral a-tocopherol Supplementation Inhibits Lipid Oxidation in Established Human Atherosclerotic Lesions

Autor: Mark A. Freeman, Malcolm J. Mitchinson, Peter J. Kirkpatrick, Ian F. Dennis, Iain R. Challis, Peter L. Weissberg, Keri L.H. Carpenter

Publikováno v: Free Radical Research. 37:1235-1244

Much experimental evidence suggests that lipid oxidation is important in atherogenesis and in epidemiological studies dietary antioxidants appear protective against cardiovascular events. However, most large clinical trials failed to demonstrate bene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6f741da035685a12348f9722d1a23c
https://doi.org/10.1080/10715760310001604143

Inhibition of lipoprotein-associated phospholipase A2diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages

Autor: Ian F. Dennis, Keri L.H. Carpenter, David S. Leake, Mark J. Arends, Malcolm J. Mitchinson, David Osborn, Colin H. Macphee, Iain R. Challis

Publikováno v: Carpenter, K L, Dennis, I F, Challis, I R, Osborn, D P, Macphee, C H, Leake, D S, Arends, M J & Mitchinson, M J 2001, ' Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages ', FEBS Letters, vol. 505, no. 3, pp. 357-63 . https://doi.org/10.1016/S0014-5793(01)02840-X

The death of macrophages contributes to atheroma formation. Oxidation renders low-density lipoprotein (LDL) cytotoxic to human monocyte-macrophages. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also termed platelet-activating factor acetylhydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682e776895ea5ce136364a22d5364d42
https://doi.org/10.1016/s0014-5793(01)02840-x

Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells

Autor: Rosamund McNair, Iain R. Challis, Nikki Figg, Catherine M. Shanahan, Peter L. Weissberg, Keri L.H. Carpenter, Diane Proudfoot, John D. Davies

Publikováno v: The Journal of biological chemistry. 280(5)

Lipid accumulation by vascular smooth muscle cells (VSMC) is a feature of atherosclerotic plaques. In this study we describe two mechanisms whereby human VSMC foam cell formation is driven by de novo synthesis of fatty acids leading to triacylglycero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d33a9ff59e33cbf908d181b4ecffc0
https://pubmed.ncbi.nlm.nih.gov/15548517

HUMAN VASCULAR SMOOTH MUSCLE CELLS EXHIBIT DE NOVO SYNTHESIS OF TRIACYLGLYCEROL VIA TWO PATHWAYS

Autor: Iain R. Challis, Peter L. Weissberg, Catherine M. Shanahan, Nikki Figg, Keri L.H. Carpenter, John Davies

Publikováno v: Cardiovascular Pathology. 13:27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bb8a1f4069415535a55dbb55d33e8e6
https://doi.org/10.1016/j.carpath.2004.03.074