Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Iain P Thomas"'
Publikováno v:
Arkivoc. 2021:256-267
Publikováno v:
Chemistry & Biology. 9:781-787
A tetraketide synthase containing a loading module (LM), the extension modules erythromycin module 1, rapamycin module 2, and erythromycin module 2 (LM-Ery1-Rap2-Ery2-TE), when expressed in Saccharopolyspora erythraea strain JC2, produced as previous
Autor:
Peter F. Leadlay, Dominic J.A Kearney, James A Reather, James Staunton, Brian A.M. Rudd, Iain P Thomas, Inès E. Holzbaur, Anand Ranganathan
Publikováno v:
Chemistry & Biology. 8(4):329-340
Background: Polyketides are structurally diverse natural products with a range of medically useful activities. Non-aromatic bacterial polyketides are synthesised on modular polyketide synthase multienzymes (PKSs) in which each cycle of chain extensio
Publikováno v:
Inorganic Chemistry. 37:612-618
The synthesis and crystal structure of cis-Fe(BPE5)2Cl2 (BPE5 = 1,2-diphospholanoethane), the first symmetrical cis-Fe(PP)2Cl2 (PP = bidentate phosphine), is reported (monoclinic, P21/n, a = 12.084(3) A, b = 14.059(2) A, c = 17.665(2) A, β = 101.77(
Autor:
Leslie D. Field, Iain P. Thomas
Publikováno v:
Inorganic Chemistry. 35:2546-2548
The synthesis of two ethylene-bridged bidentate phosphines is described. 1,2-Bis(1-phospholano)ethane ((C4H8)PCH2CH2P(C4H8)) was synthesized by the stepwise addition of 2,2-dioxo-1,3,2-dioxathiepane to H2PCH2CH2PH2. 1,2-Bis(1-phosphorinano)ethane ((C
Autor:
Anand Ranganathan, Matthew Bycroft, Ian S. Galloway, Iain P Thomas, Laurenz Kellenberger, Jesus Cortes, Barrie Wilkinson, Ulf Hanefeld, Peter F. Leadlay, Máire C. Timoney, James Staunton
Publikováno v:
Chemistrybiology. 6(10)
Background: Polyketides are structurally diverse natural products that have a range of medically useful activities. Nonaromatic bacterial polyketides are synthesised on modular polyketide synthase (PKS) multienzymes, in which each cycle of chain exte
Autor:
Leslie D., Field, Iain P., Thomas
Publikováno v:
Inorganic chemistry. 35(9)
The synthesis of two ethylene-bridged bidentate phosphines is described. 1,2-Bis(1-phospholano)ethane ((C(4)H(8))PCH(2)CH(2)P(C(4)H(8))) was synthesized by the stepwise addition of 2,2-dioxo-1,3,2-dioxathiepane to H(2)PCH(2)CH(2)PH(2). 1,2-Bis(1-phos
Publikováno v:
Chemical Communications. :1507-1508
Polystyrene resin beads carrying respectively maleimide and anthracene groups attached to extended side-chains adhere to one another in a manner consistent with an inter-bead cycloaddition reaction.
Publikováno v:
Australian Journal of Chemistry. 53:541
The bidentate ligand 1,2-bis(phosphorinan-1-yl)ethane (bpe6) reacts with iron(II) chloride to form a 2 : 1 complex trans-[Fe(bpe6)2Cl2] (2) which has been characterized crystallographically. Photochemically induced oxidation of trans-[Fe(bpe6)2Cl2] i
Autor:
Peter F. Leadlay, Graham Foster, Ylva Roddis, Brian A.M. Rudd, Andrew P. Blackaby, Barrie Wilkinson, Ines U Böhm, Christine J Rowe, James Staunton, Iain P Thomas, Anthony D Buss, Philip J. Sidebottom
Publikováno v:
Chemistry & Biology. (5):475-485
Background: Modular polyketide synthases catalyse the biosynthesis of medically useful natural products by stepwise chain assembly, with each module of enzyme activities catalysing a separate cycle of polyketide chain extension. Domain swapping betwe