Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.

Autor: Mariam Raliou, Doulaye Dembélé, Anna Düvel, Philippe Bolifraud, Julie Aubert, Tristan Mary-Huard, Dominique Rocha, François Piumi, Sophie Mockly, Maike Heppelmann, Isabelle Dieuzy-Labaye, Peter Zieger, David G E Smith, Hans-Joachim Schuberth, Iain Martin Sheldon, Olivier Sandra

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220244 (2019)

Cattle with subclinical endometritis (SCE) are sub-fertile and diagnosing subclinical uterine disease remains a challenge. The hypothesis for this study was that endometrial inflammation is reflected in mRNA expression patterns of peripheral blood le

Externí odkaz: https://doaj.org/article/f86be8729e30427f83d9ab789c496ba9

Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.

Autor: Iain Martin Sheldon, Mark H Roberts

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12906 (2010)

Ascending infections of the female genital tract with bacteria causes pelvic inflammatory disease (PID), preterm labour and infertility. Lipopolysaccharide (LPS) is the main component of the cell wall of Gram-negative bacteria. Innate immunity relies

Externí odkaz: https://doaj.org/article/f642d0505d614a72b33e6c1605314348

Oxysterols protect bovine endometrial cells against pore‐forming toxins from pathogenic bacteria

Autor: Yuqin Wang, Daphne Davies, Iain Martin Sheldon, William J. Griffiths, Anthony D Horlock, John J. Bromfield, Thomas J. R. Ormsby, Sian E. Owens, James G. Cronin

Publikováno v: The FASEB Journal. 35

Many species of pathogenic bacteria secrete toxins that form pores in mammalian cell membranes. These membrane pores enable the delivery of virulence factors into cells, result in the leakage of molecules that bacteria can use as nutrients, and facil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9cbe743c922379761f9ca58e2c3473
https://doi.org/10.1096/fj.202100036r

FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants

Autor: Caroline Eozenou, Vincent Mauffré, Audrey Lesage-Padilla, Daniel Vaiman, Gareth D. Healey, Corinne Giraud-Delville, Akio Miyamoto, Sylvaine Camous, Iain Martin Sheldon, Fabienne Constant, Maëlle Pannetier, Olivier Sandra, Takashi Shimizu, Philippe Bolifraud

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1478 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2020, 21 (4), pp.1478. ⟨10.3390/ijms21041478⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (4), pp.1478. ⟨10.3390/ijms21041478⟩
Volume 21
Issue 4

Forkhead Box L2 (FOXL2) is a member of the FOXL class of transcription factors, which are essential for ovarian differentiation and function. In the endometrium, FOXL2 is also thought to be important in cattle
however, it is not clear how its ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d9a24870d667c4c07abac1d55dddc4
https://www.mdpi.com/1422-0067/21/4/1478

Toll-like receptor and related cytokine mRNA expression in bovine corpora lutea during the oestrous cycle and pregnancy

Autor: John E. Gadsby, Daniel H Poole, Iain Martin Sheldon, P.W. Farin, HA Faircloth, M. D’Annibale-Tolhurst, J. Chang, AM Tyson Nipper

Publikováno v: Reproduction in Domestic Animals. 52:495-504

Improving our understanding of the mechanisms controlling the corpus luteum (CL) and its role in regulating the reproductive cycle should lead to improvements in the sustainability of today's global animal industry. The corpus luteum (CL) is a transi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c6e79344453abee1d4f5de1dd965a2
https://doi.org/10.1111/rda.12940