Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

Autor: Thomas J. R. Ormsby, Sian E. Owens, Liam Clement, Tom J. Mills, James G. Cronin, John J. Bromfield, Iain Martin Sheldon

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by releasing nutrients, delivering virulence factors, and causing lytic cell damage - cytolysis. O

Externí odkaz: https://doaj.org/article/142f04d5f4314de7ab090c03825dae45

Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.

Autor: Mariam Raliou, Doulaye Dembélé, Anna Düvel, Philippe Bolifraud, Julie Aubert, Tristan Mary-Huard, Dominique Rocha, François Piumi, Sophie Mockly, Maike Heppelmann, Isabelle Dieuzy-Labaye, Peter Zieger, David G E Smith, Hans-Joachim Schuberth, Iain Martin Sheldon, Olivier Sandra

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220244 (2019)

Cattle with subclinical endometritis (SCE) are sub-fertile and diagnosing subclinical uterine disease remains a challenge. The hypothesis for this study was that endometrial inflammation is reflected in mRNA expression patterns of peripheral blood le

Externí odkaz: https://doaj.org/article/f86be8729e30427f83d9ab789c496ba9

Review: Perspective on high-performing dairy cows and herds

Autor: Frank M. Mitloehner, Jack H. Britt, M.F. Hutjens, C.D. Dechow, P.L. Ruegg, G.A. Jones, Iain Martin Sheldon, Patrice Humblot, R.A. Cushman, Jeffrey S. Stevenson, Hilary Dobson

Publikováno v: Animal, Vol 15, Iss, Pp 100298-(2021)
ANIMAL

Milk and dairy products provide highly sustainable concentrations of essential amino acids and other required nutrients for humans; however, amount of milk currently produced per dairy cow globally is inadequate to meet future needs. Higher performin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5965cb6fa597eac0764c031b706e9695
https://cronfa.swan.ac.uk/Record/cronfa57314/Download/57314__20404__9ff843b10de9464ba429d3702d339d4b.pdf

FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants

Autor: Caroline Eozenou, Vincent Mauffré, Audrey Lesage-Padilla, Daniel Vaiman, Gareth D. Healey, Corinne Giraud-Delville, Akio Miyamoto, Sylvaine Camous, Iain Martin Sheldon, Fabienne Constant, Maëlle Pannetier, Olivier Sandra, Takashi Shimizu, Philippe Bolifraud

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1478 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2020, 21 (4), pp.1478. ⟨10.3390/ijms21041478⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (4), pp.1478. ⟨10.3390/ijms21041478⟩
Volume 21
Issue 4

Forkhead Box L2 (FOXL2) is a member of the FOXL class of transcription factors, which are essential for ovarian differentiation and function. In the endometrium, FOXL2 is also thought to be important in cattle
however, it is not clear how its ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d9a24870d667c4c07abac1d55dddc4
https://www.mdpi.com/1422-0067/21/4/1478

Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.

Autor: Iain Martin Sheldon, Mark H Roberts

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12906 (2010)

Ascending infections of the female genital tract with bacteria causes pelvic inflammatory disease (PID), preterm labour and infertility. Lipopolysaccharide (LPS) is the main component of the cell wall of Gram-negative bacteria. Innate immunity relies

Externí odkaz: https://doaj.org/article/f642d0505d614a72b33e6c1605314348