Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Iain M. Porter"'
Autor:
Agathe Lermant, Gwenaëlle Rabussier, Henriëtte L. Lanz, Lindsay Davidson, Iain M. Porter, Colin E. Murdoch
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107240- (2023)
Summary: Although recently developed placenta-on-chip systems opened promising perspectives for placental barrier modeling, they still lack physiologically relevant trophoblasts and are poorly amenable to high-throughput studies. We aimed to implemen
Externí odkaz:
https://doaj.org/article/a5843bf8b2b74ec793eae1ebf1ab0367
Autor:
Katharina Schleicher, Michael Porter, Sara ten Have, Ramasubramanian Sundaramoorthy, Iain M. Porter, Jason R. Swedlow
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Regulation of protein phosphatase activity by endogenous protein inhibitors is an important mechanism to control protein phosphorylation in cells. We recently identified Biorientation defective 1 (Bod1) as a small protein inhibitor of protein phospha
Externí odkaz:
https://doaj.org/article/afbcbb801cf14923a997a6fbdf777098
Autor:
Sahar Esmaeeli-Nieh, Michaela Fenckova, Iain M Porter, M Mahdi Motazacker, Bonnie Nijhof, Anna Castells-Nobau, Zoltan Asztalos, Robert Weißmann, Farkhondeh Behjati, Andreas Tzschach, Ute Felbor, Harry Scherthan, Seyed Morteza Sayfati, H Hilger Ropers, Kimia Kahrizi, Hossein Najmabadi, Jason R Swedlow, Annette Schenck, Andreas W Kuss
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006022 (2016)
Here we report a stop-mutation in the BOD1 (Biorientation Defective 1) gene, which co-segregates with intellectual disability in a large consanguineous family, where individuals that are homozygous for the mutation have no detectable BOD1 mRNA or pro
Externí odkaz:
https://doaj.org/article/fdc77123695841afb9a2e0657546489b
Autor:
Nicodème Paul, Kay Hofmann, Charlotte Kleiss, Ksenia Krupina, Sadek Fournane, Izabela Sumara, Thibaud Metzger, Jason R. Swedlow, Olivier Poch, Laurent Brino, Benoit Fischer, Wolfgang Raffelsberger, Iain M. Porter, Stephane Schmucker
Publikováno v:
Developmental Cell
Developmental Cell, Elsevier, 2016, 36 (1), pp.63-78. ⟨10.1016/j.devcel.2015.12.017⟩
Developmental cell
Developmental Cell, Elsevier, 2016, 36 (1), pp.63-78. ⟨10.1016/j.devcel.2015.12.017⟩
Developmental cell
SummaryMitosis ensures equal segregation of the genome and is controlled by a variety of ubiquitylation signals on substrate proteins. However, it remains unexplored how the versatile ubiquitin code is read out during mitotic progression. Here, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a284c2b563ef59b8645b30e8f68c3203
https://hal.archives-ouvertes.fr/hal-03080547
https://hal.archives-ouvertes.fr/hal-03080547
Autor:
M. Mahdi Motazacker, Hossein Najmabadi, Farkhondeh Behjati, Sahar Esmaeeli-Nieh, Zoltan Asztalos, Harry Scherthan, Andreas W. Kuss, Andreas Tzschach, Michaela Fenckova, Seyed Morteza Sayfati, Iain M. Porter, Robert Weißmann, Anna Castells-Nobau, Kimia Kahrizi, Bonnie Nijhof, Jason R. Swedlow, Ute Felbor, Hans-Hilger Ropers, Annette Schenck
Publikováno v:
PLoS genetics, 12(5). Public Library of Science
PLoS Genetics, Vol 12, Iss 5, p e1006022 (2016)
PLoS Genetics
Plos Genetics, 12, 5, pp. e1006022
Plos Genetics, 12, e1006022
PLoS Genetics, Vol 12, Iss 5, p e1006022 (2016)
PLoS Genetics
Plos Genetics, 12, 5, pp. e1006022
Plos Genetics, 12, e1006022
Here we report a stop-mutation in the BOD1 (Biorientation Defective 1) gene, which co-segregates with intellectual disability in a large consanguineous family, where individuals that are homozygous for the mutation have no detectable BOD1 mRNA or pro
Autor:
Jason R. Swedlow, Markus Posch, Jennifer R. Winter, Jonas F. Dorn, Nunu Mchedlishvili, Hunter L. Elliott, Patrick Meraldi, Ana C. Amaro, Andrew D. McAinsh, Emma M. King, Sarah E. McClelland, Alberto Toso, Iain M. Porter, Khuloud Jaqaman, Gaudenz Danuser
Publikováno v:
The Journal of cell biology
The Journal of Cell Biology
The Journal of Cell Biology
An automated, quantitative 4D image analysis method is used to track kinetochore dynamics in metaphase cells.
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which th
During mitosis in most eukaryotic cells, chromosomes align and form a metaphase plate halfway between the spindle poles, about which th
Autor:
Iain M. Porter, Nigel D. Stow
Publikováno v:
Journal of General Virology. 85:583-591
Open reading frame UL12 of herpes simplex virus type 1 (HSV-1) encodes an alkaline nuclease that has previously been implicated in processing the complex, branched, viral DNA replication intermediates and allowing egress of DNA-containing capsids fro
Publikováno v:
Nature Communications
Mitotic entry and progression require the activation of several mitotic kinases and the proper regulation and localization of several phosphatases. The activity and localization of each of these enzymes is tightly controlled through a series of speci
Autor:
Andrew D. McAinsh, J. Julian Blow, Jason R. Swedlow, Sarah E. McClelland, Guennadi A. Khoudoli, Jens S. Andersen, Christopher J. Hunter, Iain M. Porter
Publikováno v:
Porter, I M, McClelland, S E, Khoudoli, G A, Hunter, C J, Andersen, J S, McAinsh, A D, Blow, J J & Swedlow, J R 2007, ' Bod1, a novel kinetochore protein required for chromosome biorientation ', Journal of Cell Biology, vol. 179, no. 2, pp. 187-197 . https://doi.org/10.1083/jcb.200704098
The Journal of Cell Biology
The Journal of Cell Biology
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33644c4c4d2a3c6a423f37407a31006b
https://portal.findresearcher.sdu.dk/da/publications/4bb05ca0-e453-11dc-a57f-000ea68e967b
https://portal.findresearcher.sdu.dk/da/publications/4bb05ca0-e453-11dc-a57f-000ea68e967b
Autor:
Nigel D. Stow, Iain M. Porter
Publikováno v:
The Journal of general virology. 85(Pt 12)
The alkaline nuclease (AN) encoded by gene UL12 of herpes simplex virus type 1 (HSV-1) is essential for efficient virus replication but its role during the lytic cycle remains incompletely understood. Inactivation of the UL12 gene results in reductio