Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Iain L O Buxton"'
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12372 (2010)
We tested the hypothesis that the stretch-activated, four-transmembrane domain, two pore potassium channels (K2P), TREK-1 and TRAAK are gestationally-regulated in human myometrium and contribute to uterine relaxation during pregnancy until labor.We d
Externí odkaz:
https://doaj.org/article/5a6ca33bdca34f8493e040822c36cfba
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 1005 (2023)
Preterm labor leading to preterm birth is the leading cause of infant morbidity and mortality. At the present time, nothing can reliably halt labor once it begins. The knowledge that agonists of the β2 adrenergic receptor relax airway smooth muscle
Externí odkaz:
https://doaj.org/article/cc5ba96ccbdf41b7a2e2394b1e531668
Publikováno v:
Reproductive Sciences. 30:124-134
Preterm labor leading to preterm birth is the leading cause of infant morbidity and mortality. Although β2 adrenergic agonists fail to provide adequate tocolysis, the expression of the β3 adrenergic receptor in myometrium and its unique signaling s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a05561a97f4f6bae28e7bef1aa35a1d
https://doi.org/10.1007/s43032-022-00917-y
https://doi.org/10.1007/s43032-022-00917-y
Publikováno v:
The Journal of physiologyReferences.
Approximately 10% of US births deliver preterm before 37 weeks of completed gestation. Premature infants are at risk for life-long debilitating morbidities and death, and spontaneous preterm labour explains 50% of preterm births. In all cases existin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36b737fad40b3c3f607072755bdd951
https://pubmed.ncbi.nlm.nih.gov/35941750
https://pubmed.ncbi.nlm.nih.gov/35941750
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:444-453
Currently available tocolytics are ineffective at significantly delaying preterm birth. This is due in part to our failure to better understand the mechanisms that drive spontaneous preterm labor (sPTL). Cyclic nucleotides are not the primary contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dfd20977e86859428833b2f121b5717
https://doi.org/10.1124/jpet.120.000427
https://doi.org/10.1124/jpet.120.000427
Autor:
Suzann Duan, Dominic P. Basile, Iain L. O. Buxton, Andrew Oman, Cristina M. Alvira, Cristiana Iosef, Westin K. Chan
Publikováno v:
Journal of Cellular and Molecular Medicine
A wealth of evidence supports the broad therapeutic potential of NF‐κB and EZH2 inhibitors as adjuvants for breast cancer treatment. We contribute to this knowledge by elucidating, for the first time, unique regulatory crosstalk between EZH2, NF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7999dd6bf41026cfc83c3f8dfc1961c8
http://europepmc.org/articles/PMC6714229
http://europepmc.org/articles/PMC6714229
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 597, p 597 (2021)
Volume 22
Issue 2
International Journal of Molecular Sciences, Vol 22, Iss 597, p 597 (2021)
Metastasis accounts for over 90% of cancer-related deaths, yet the mechanisms guiding this process remain unclear. Secreted nucleoside diphosphate kinase A and B (NDPK) support breast cancer metastasis. Proteomic evidence confirms their presence in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a7a7c871269e4afe44e07165f51833
Autor:
Suzann Duan, Iain L. O. Buxton
Publikováno v:
Cancers. 14:2450
An examination of the origins of medical approaches to breast cancer marks this disease as one of the most difficult to manage. As the early identification, diagnosis and treatment of breast cancer evolve, we will move to a time when each patient and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d47762fe685301390b33dfec283951
https://doi.org/10.3390/cancers14102450
https://doi.org/10.3390/cancers14102450
Autor:
Scott D. Barnett, Iain L. O. Buxton
Publikováno v:
Journal of Cellular and Molecular Medicine
Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA‐approved treatment can prevent labour or help a foetus remain in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4c46f34921fa5d2eb68fbc648acfd4
http://europepmc.org/articles/PMC6237580
http://europepmc.org/articles/PMC6237580
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e112df58db49074ccfe9e5c6f049d102
https://doi.org/10.1096/fasebj.2020.34.s1.04206
https://doi.org/10.1096/fasebj.2020.34.s1.04206