A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities [version 2; peer review: 2 approved]

Autor: Sushmita Sridhar, Sally Forrest, Iain Kean, Jamie Young, Josefin Bartholdson Scott, Mailis Maes, Joana Pereira-Dias, Surendra Parmar, Matthew Routledge, Dominic Sparkes, Lucy Rivett, Gordon Dougan, Michael Weekes, Martin Curran, Ian Goodfellow, Stephen Baker

Publikováno v: Wellcome Open Research, Vol 5 (2020)

The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the provision of additional diagnostic capacity. Academic laboratories, many of which are closed

Externí odkaz: https://doaj.org/article/1c64bfcca6dd49fa8785252143de5682

HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities

Autor: Nazreen F. Hadjirin, Elizabeth Lay, Duncan J. Maskell, Iain Kean, Andrew J. Grant, Xiaoliang Ba, Lajos Kalmar, James L. N. Wood, Sunil Gupta, O. Restiff, S. P. W. de Vries, Harriet Bartlett, Mark A. Holmes, Juan Hernandez-Garcia, Alexander W. Tucker, Mark P. Stevens, Michael D. Bateman

Publikováno v: Kalmar, L, Gupta, S, Kean, I R L, Ba, X, Hadjirin, N, Lay, E M, de Vries, S P W, Bateman, M, Bartlet, H, Hernandez-Garcia, J, Tucker, A W, Restif, O, Stevens, M P, Wood, J L N, Maskell, D J, Grant, A J & Holmes, M A 2022, ' HAM-ART : An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities ', PLoS Genetics, vol. 18, no. 3, e1009776, pp. e1009776 . https://doi.org/10.1371/journal.pgen.1009776

Shotgun metagenomics is a powerful tool to identify antimicrobial resistance (AMR) genes in microbiomes but has the limitation that extrachromosomal DNA, such as plasmids, cannot be linked with the host bacterial chromosome. Here we present a laborat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f34697ea0c4ebd00c33e4da94471a6c

P48 The limited yield of cultures in the critically ill child

Autor: John Clark, Deborah White, Esther Daubney, Martin Curran, Rachel Bousfield, Theodore Gouliouris, Elizabeth Powell, Adam Palmer, Shruti Agrawal, David Inwald, Iain Kean, M. Estée Török, Stephen Baker, Nazima Pathan

Publikováno v: JAC-Antimicrobial Resistance. 4

Background Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e51eb2299862d5e94327019233bb5752
https://doi.org/10.1093/jacamr/dlac004.047

A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities

Autor: Lucy Rivett, Joana Pereira-Dias, Michael P. Weekes, Ian Goodfellow, Martin D. Curran, Stephen Baker, Mailis Maes, Sushmita Sridhar, Dominic Sparkes, Iain Kean, Jamie Young, Sally Forrest, Josefin Bartholdson Scott, Surendra Parmar, Gordon Dougan, Matthew Routledge

Publikováno v: Wellcome Open Research

The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the provision of additional diagnostic capacity. Academic laboratories, many of which are closed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1755874cb3e90ca842754eb482965d33
https://doi.org/10.12688/wellcomeopenres.15937.2

Author response: Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

Autor: Simone Hargreaves, Francescsa Nice, Naidine Escoffery, Paul J. Lehner, Lucy Rivett, Caroline Saunders, Julie Harris, Neil Bartholomew, Natalia Savoinykh Yarkoni, Anne Meadows, Anne-Laure Vallier, Mary Kasanicki, Joe Marsden, Jo Wright, Charlotte J. Houldcroft, Chris Workman, Mark Ferris, Carmen M. Treacy, Kelvin Hunter, Anita Furlong, Harmeet Gill, Michael P. Weekes, Surendra Parmar, Nika Romashova, Kenneth G. C. Smith, Greg Hannon, Ashlea Bucke, Chris McNicholas, Debbie Read, Myra Hosmillo, Sushmita Sridhar, Linda Pointon, Jane Gray, John Bradley, Josh Hodgson, Emma Le Gresley, Joana Pereira-Dias, Lori Turner, Nicola Ramenatte, Stefan Gräf, Ben Warne, Claire Cormie, Jane Rowlands, Jane Kennet, Penelope-Jane Eames, Christopher Huang, Barbara J. Graves, Sally Forrest, Helen Butcher, Daniela Caputo, Joanna Calder, Anna Yakovleva, Jo Price, Aileen Narcorda, M. Estée Török, Sarah Hewitt, Martin D. Curran, Ian Goodfellow, Valentina Ruffolo, Cordova Jiménez, Michelle Wantoch, Lisa Thake, Zhen Tong, Isobel Jarvis, Laura Canna, Paul A. Lyons, Isabel Cruz, Benjamin J. Dunmore, Anne Roberts, William David Córdova Jiménez, Lucy Worboys, Helen Dolling, Rebecca Rastall, Ommar Omarjee, Sarah L Caddy, Barrie Bailey, William L Hamilton, Ekaterina Legchenko, Debra Clapham-Riley, Rachel Sutcliffe, Ciara O’Donnell, Fahad A Khokhar, Laura G Caller, Kathleen E Stirrups, Fathima Nisha Begum Samad, Hongyi Zhang, Jamie Young, Sofia Papadia, Criona O Brien, Tobias Tilly, Jennifer M. Martin, Nick K Jones, Kirsty Lagadu, Carla Ribeiro, Ailsa Bowring, Nicholas J Matheson, Tim Gould, D. Johnson, Ashley Shaw, Simon McCallum, Tim Raine, Daniel Lewis, Ariana Betancourt, Stewart Fuller, Afzal N. Chaudhry, Lenette Mactavous, Heather F Jones, William David, Rachel Doughton, Theresa Feltwell, Luke W. Meredith, Nathalie Kingston, Hannah Stark, Georgie Bowyer, Gregory J. Hannon, Karen Brookes, Dominic Sparkes, Iain Kean, Ravi Gupta, Cherry Publico, Katie Dempsey, Matthew Routledge, Nicholas K Jones, Aloka De Sa, Giles Wright, Laura Bergamaschi, Claire Mather, Rutendo Nyagumbo, Maddie Epping, Jack Levy, Marianne Perera, Christian Sparke, Fatima Nb Samad, Nicola Reynolds, Michael Gill, Hugo Tordesillas, Oisin Huhn, Anne Elmer, Geraldine Martell, Mateusz Strezlecki, Grant Hall, Andrew Hinch, Gordon Dougan, Jennifer Webster, Helen Murphy, Stephen Baker, Aminu S Jahun, Mark Toshner, Angela Wright, Natalie Quinnell, Joy Shih, Caroline Trotter, Nicholas K. Brown, Federica Mescia, John S. Bradley, Jennifer Wood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0ce2cf112b5250a430a67863c74b18e
https://doi.org/10.7554/elife.59391.sa2