Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Iain K Pemberton"'
Autor:
Céline Ronin, David Mendes Costa, Joana Tavares, Joana Faria, Fabrice Ciesielski, Paola Ciapetti, Terry K Smith, Jane MacDougall, Anabela Cordeiro-da-Silva, Iain K Pemberton
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193602 (2018)
The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly commensurate with Hst2/SIRT2
Externí odkaz:
https://doaj.org/article/e4b7312a30c44b1bbe495d18d3b04ba1
Autor:
Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L Major, Fabrice Ciesielski, Iain K Pemberton, Jane MacDougall, Paola Ciapetti, Terry K Smith, Anabela Cordeiro-da-Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006180 (2018)
Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-rel
Externí odkaz:
https://doaj.org/article/f6e4a1edfb98480288b07d74ed1a4300
Autor:
Concetta Dagostino, Manuela De Gregori, Christian Gieger, Judith Manz, Ivan Gudelj, Gordan Lauc, Laura Divizia, Wei Wang, Moira Sim, Iain K Pemberton, Jane MacDougall, Frances Williams, Jan Van Zundert, Dragan Primorac, Yurii Aulchenko, Leonardo Kapural, Massimo Allegri, PainOmics Group
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176372 (2017)
Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics stud
Externí odkaz:
https://doaj.org/article/02cc55ad14ff4ecb825edb2cb5cdbd97
Autor:
Anabela Cordeiro-da-Silva, Louise L. Major, Mónica Sá, Paola Ciapetti, Jane MacDougall, Terry K. Smith, Fabrice Ciesielski, Joana Tavares, Nuno Santarém, Nathalie Trouche, Emily A. Dickie, Iain K. Pemberton, Céline Ronin
Publikováno v:
Antimicrob Agents Chemother
Funding from the European Community's Seventh Framework Programme under grant agreements No. 602773 (Project KINDRED) was received for all partners in this work. This work also received funds from FCT - Fundação para a Ciência e a Tecnologia/Minis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03593d13f339e842adf9b91dc2d37197
https://hdl.handle.net/10023/24164
https://hdl.handle.net/10023/24164
Autor:
Viktoria Dotz, Stephan R. Targan, Hazel E. Drummond, Gildardo Barron, Daisy Jonkers, Daniel Kolarich, Tim van den Heuvel, Gordan Lauc, David C. Wilson, Elaine R. Nimmo, Marco R. Bladergroen, Frano Vukovic, Manfred Wuhrer, Nicholas A. Kennedy, Hans Dalebout, Karli R. Reiding, Alex Adams, Iain K. Pemberton, Daryl L. Fernandes, Vito Annese, Maja Pučić-Baković, Fabrizio Bossa, Silvio Danese, Genadij Razdorov, Rahul Kalla, Irena Trbojević-Akmačić, Victoria Merrick, Igor Rudan, Evropi Theodoratou, Ray Boyapati, Nicholas T. Ventham, Noortje de Haan, Richard A. Gardner, Florent Clerc, Harry Campbell, Jasminka Krištić, Erdmann Rapp, Jerko Štambuk, Dermot P.B. McGovern, Mirna Šimurina, Natalia Manetti, Archana Shubhakar, Anna Kohn, Jack Satsangi, Paulina A. Urbanowicz, Marieke Pierik, Guinevere S. M. Kammeijer, Vlatka Zoldoš, Orazio Palmieri, Mislav Novokmet, Yurii S. Aulchenko, Renata D'Incà, Daniel I. R. Spencer, KR O’Leary, Olga Gornik, Marija Vilaj, Anna Latiano, Giuseppe Biscaglia, Marija Pezer
Publikováno v:
Gastroenterology, 155(3), 829-843
Background & Aims Biomarkers are needed for early detection of Crohn’s disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex posttranslational modification of proteins that affects their stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea3b07d3b484e0c76e1325ccd67205c
https://pubmed.ncbi.nlm.nih.gov/29792883
https://pubmed.ncbi.nlm.nih.gov/29792883
Autor:
Harry Campbell, Iain K. Pemberton, Nicholas A. Kennedy, Vito Annese, Dermot P.B. McGovern, Vlatka Zoldoš, Elaine R. Nimmo, Evropi Theodoratou, Igor Rudan, Gordan Lauc, Nicholas T. Ventham, Maja Pučić-Baković, Daniel Kolarich, Jack Satsangi, Manfred Wuhrer, Daryl L. Fernandes
Publikováno v:
Nature Reviews Gastroenterology and Hepatology, 11(10), 588-600
A number of genetic and immunological studies give impetus for investigating the role of glycosylation in IBD. Experimental mouse models have helped to delineate the role of glycosylation in intestinal mucins and to explore the putative pathogenic ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b11a256986b5feb515d5eabaa55908
https://hdl.handle.net/1887/104928
https://hdl.handle.net/1887/104928
Publikováno v:
Journal of Molecular Biology. 299:859-864
RNA polymerase forms a highly stable preinitiation complex at many prokaryotic promoters in the absence of ribonucleotides. These are often characterised by the longevity of the DNA strand-separated (open) complex in the presence of heparin. In contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb14ba388bf622532f613b3c58ea103
https://doi.org/10.1006/jmbi.2000.3780
https://doi.org/10.1006/jmbi.2000.3780
Autor:
Iain K. Pemberton, Malcolm Buckle
Publikováno v:
Journal of Molecular Recognition. 12:322-327
We have used surface plasmon resonance (SPR) to follow variations in the concentrations of binary complexes as RNA polymerase moves into a transcriptionally competent initiation complex with immobilized DNA fibres containing promoter sequences. The u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7518149cc71367bef28f5f5d8f2f3b10
https://doi.org/10.1002/(sici)1099-1352(199909/10)12:5<322::aid-jmr471>3.0.co
https://doi.org/10.1002/(sici)1099-1352(199909/10)12:5<322::aid-jmr471>3.0.co
Autor:
Najma Rachidi, Aude L. Foucher, Philippe Bastin, Sarah Gharbi, Thierry Blisnick, Iain K. Pemberton, Gerald F. Späth
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩
Antimicrobial Agents and Chemotherapy; Vol 57
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩
Antimicrobial Agents and Chemotherapy, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩
Antimicrobial Agents and Chemotherapy; Vol 57
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 57 (3), pp.1252-1261. ⟨10.1128/AAC.01983-12⟩
The protozoan parasite Leishmania donovani undergoes several developmental transitions in its insect and vertebrate hosts that are induced by environmental changes. The roles of protein kinases in these adaptive differentiation steps and their potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77beddca7e892b1eb0668a08856db844
https://hal-pasteur.archives-ouvertes.fr/pasteur-01433417
https://hal-pasteur.archives-ouvertes.fr/pasteur-01433417
Autor:
Catherine Klersy, Iain K. Pemberton, Jane MacDougall, Moira Sim, Lennart C. Karssen, Richard Rauck, Yurii S. Aulchenko, Manuela De Gregori, Frances M K Williams, Guido Fanelli, Massimo Allegri, Cristina E. Minella, Gordan Lauc, Andrea Skelin, Judith Manz, Wei Wang, Dragan Primorac, Klaas Buyse, Jan Van Zundert, Christian Gieger, Leonardo Kapural, Ivan Gudelj
Publikováno v:
Allegri, M, De Gregori, M, Minella, C E, Klersy, C, Wang, W, Sim, M, Gieger, C, Manz, J, Pemberton, I K, MacDougall, J, Williams, F M K, Van Zundert, J, Buyse, K, Lauc, G, Gudelj, I, Primorac, D, Skelin, A, Aulchenko, Y S, Karssen, L C, Kapural, L, Rauck, R & Fanelli, G 2016, ' Omics' biomarkers associated with chronic low back pain : Protocol of a retrospective longitudinal study ', BMJ Open, vol. 6, no. 10, e012070 . https://doi.org/10.1136/bmjopen-2016-012070
BMJ Open
BMJ Open
Introduction Chronic low back pain (CLBP) produces considerable direct costs as well as indirect burdens for society, industry and health systems. CLBP is characterised by heterogeneity, inclusion of several pain syndromes, different underlying molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e067b6996bab7d13111e76cffaa75d
https://doi.org/10.1136/bmjopen-2016-012070
https://doi.org/10.1136/bmjopen-2016-012070