Výsledky vyhledávání - "Iain J. Uings"

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- and Long-Distance Conformational Changes

Autor: Paola Nocerino, Iain J. Uings, Ryan P. Bingham, Alessandra Corazza, Diana Canetti, Guglielmo Verona, Palma Mangione, Christopher A. Waudby, John Christodoulou, Vittorio Bellotti, Mark B. Pepys, Graham W. Taylor

Publikováno v: Journal of Medicinal Chemistry

The wild type protein, transthyretin (TTR), and over 120 genetic TTR variants are amyloidogenic and cause, respectively, sporadic and hereditary systemic TTR amyloidosis. The homotetrameric TTR contains two identical thyroxine binding pockets, occupa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838c410a107c0493cfd238da6acaa6c6
https://doi.org/10.1021/acs.jmedchem.9b01037

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Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1β-stimulated nuclear factor κB (NF-κB) pathway activation: IRAK-1 associates with the NF-κB essential modulator (NEMO) upon receptor stimulation

Autor: Emma-Louise COOKE, Iain J. UINGS, Chulin L. XIA, Patricia WOO, Keith P. RAY

Publikováno v: Biochemical Journal. 359:403-410

The interleukin-1 (IL-1)-receptor-associated kinase (IRAK-1) is essential for IL-1-stimulated nuclear factor κB (NF-κB) activation. To study the role of IRAK-1 in IL-1β signalling, we have generated a set of IRAK-1 variants that express distinct d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0b092969197cc6cf5a30a13ccb60a89
https://doi.org/10.1042/bj3590403

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MODIFIED PEPTIDE ANTAGONISTS OF INTERLEUKIN 5 EXHIBIT EXTENDED IN VIVO PERSISTENCE BUT RESTRICTED SPECIES SPECIFICITY

Autor: Palaniappan Balasubramanian, Murray McKinnon, England Bruce Padon, Ronald W. Barrett, Alan P Beresford, Iain J. Uings, Qun Yin, Laura Dash, Sarah Kearney, Patricia G. McLoughlin

Publikováno v: Cytokine. 15:10-19

AF18748 is disulphide-linked homodimeric peptide with 19 amino acids in each chain that antagonises the action of the eosinophil-specific cytokine, interleukin 5 (IL-5). We have generated a set of N-terminally truncated peptides derived from AF18748

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72f0215934403e3eefa9f77079ca8a8
https://doi.org/10.1006/cyto.2001.0886

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Effects of the Indolocarbazole 3744W on the Tyrosine Kinase Activity of the Cytoplasmic Domain of the Platelet-Derived Growth Factor β-Receptor

Autor: Robert W. Bonser, Graham D. Spacey, Iain J. Uings

Publikováno v: Cellular Signalling. 11:95-100

The cytoplasmic domain of the platelet-derived growth factor (PDGF) beta-receptor was expressed in insect cells by using a baculovirus system. The resulting protein was a constitutively active tyrosine kinase that could phosphorylate both protein and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769f3bb17563dd424fdce1ee25b124b9
https://doi.org/10.1016/s0898-6568(98)00039-4

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Indolocarbazoles

Autor: Graham D. Spacey, S. J. Hirst, Martin John Slater, Robert W. Bonser, Iain J. Uings

Publikováno v: Biochemical Pharmacology. 55:261-271

A quantitative assay for measuring the autophosphorylation of platelet-derived growth factor (PDGF) receptors in intact vascular smooth muscle cells has been developed and used to screen for novel tyrosine kinase (TK) inhibitors. Several novel inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3174834219f78b43a2fbe5314460128b
https://doi.org/10.1016/s0006-2952(97)00460-7

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Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis

Autor: Satoko, Fujihara, Carol, Ward, Ian, Dransfield, Ronald T, Hay, Iain J, Uings, Brian, Hayes, Stuart N, Farrow, Christopher, Haslett, Adriano G, Rossi

Publikováno v: European journal of immunology. 32(2)

Apoptosis renders eosinophils functionally effete and marks them for "silent" removal from inflamed sites by macrophages. We show, for the first time, that eosinophils exposed to TNF-alpha rapidly lose their cytoplasmic levels of IkappaBalpha, the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::765cac97874c7ce15a80acb5d90850f5
https://pubmed.ncbi.nlm.nih.gov/11813164

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Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein

Autor: Cornelieke Pals, Niels Geijsen, Paul J. Coffer, Iain J. Uings, Jan-Willem J. Lammers, Murray McKinnon, Leo Koenderman, John Armstrong, Jan A. M. Raaijmakers

Publikováno v: Science (New York, N.Y.). 293(5532)

Cytokine receptors consist of multiple subunits, which are often shared between different receptors, resulting in the functional redundancy sometimes observed between cytokines. The interleukin 5 (IL-5) receptor consists of an IL-5-specific alpha-sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0576e2f6f66c56ed60cd82cc910d5e
https://pubmed.ncbi.nlm.nih.gov/11498591

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