Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Iain J. MacLeod"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Iain MacLeod et al. develop the Pan-Degenerate Amplification and Adaptation (PANDAA) point mutation assay to detect HIV drug resistance mutations. This method can be applied to any pathogen where target-proximal genetic variability hinders diagnostic
Externí odkaz:
https://doaj.org/article/f79a51c5dc574d0197305537b3b9d5a5
Autor:
Dorcas Maruapula, Iain J. MacLeod, Sikhulile Moyo, Rosemary Musonda, Kaelo Seatla, Kesaobaka Molebatsi, Melvin Leteane, Max Essex, Simani Gaseitsiwe, Christopher F. Rowley
Publikováno v:
AAS Open Research, Vol 3 (2021)
Background: HIV-1 drug resistance poses a major threat to the success of antiretroviral therapy. The high costs of available HIV drug resistance assays prohibit their routine usage in resource-limited settings. Pan-degenerate amplification and adapta
Externí odkaz:
https://doaj.org/article/4ea9c67337e84e60af4a080920b24d81
Autor:
Patricia S. Rantshabeng, Sikhulile Moyo, Natasha O. Moraka, Andrew Ndlovu, Iain J. MacLeod, Simani Gaseitsiwe, Ishmael Kasvosve
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy. Meth
Externí odkaz:
https://doaj.org/article/3d24fb63dd5448f7a9012069ab64ce19
Autor:
Rosemary Musonda, Kaelo K Seatla, Simani Gaseitsiwe, Melvin Leteane, Iain J. MacLeod, Dorcas Maruapula, Kesaobaka Molebatsi, Christopher F. Rowley, Sikhulile Moyo, Max Essex
Publikováno v:
AAS Open Research
Background:HIV-1 drug resistance poses a major threat to the success of antiretroviral therapy. The high costs of available HIV drug resistance assays prohibit their routine usage in resource-limited settings. Pan-degenerate amplification and adaptat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5319d4cd02cdf20bde4a6a3c938a4b
https://pubmed.ncbi.nlm.nih.gov/34036243
https://pubmed.ncbi.nlm.nih.gov/34036243
Autor:
Iain J MacLeod, Tony Minson
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9560 (2010)
The envelope of HSV-1 contains a number of glycoproteins, four of which are essential for virus entry. Virus particles lacking gB, gD, gH or gL are entry-defective, although these viruses retain the ability to bind to the plasma membrane via the rema
Externí odkaz:
https://doaj.org/article/170a2c635a124985bfce64cbaf6955db
Autor:
Iain J. MacLeod, Sikhulile Moyo, Simani Gaseitsiwe, Natasha O. Moraka, Patricia S. Rantshabeng, Andrew Ndlovu, Ishmael Kasvosve
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-8 (2017)
BMC Infectious Diseases
BMC Infectious Diseases
Background Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy. Methods We us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef4734e28be72a69516259f6348d4cc
http://link.springer.com/article/10.1186/s12879-017-2832-8
http://link.springer.com/article/10.1186/s12879-017-2832-8
Global efforts to ensure that 90% of all HIV-infected people receiving antiretroviral therapy (ART) will be virally suppressed by 2020 could be crippled by increases in acquired and transmitted HIV drug resistance (HIVDR), which challenge ART efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38211ffa49187df6d0f745db1c9b4d8e
https://doi.org/10.1101/795054
https://doi.org/10.1101/795054
Publikováno v:
Diseases of the colon and rectum. 62(5)
BACKGROUND Data on tissue distribution of human papillomavirus types in anal high-grade squamous intraepithelial lesions are limited and the impact on treatment outcomes poorly understood. OBJECTIVE We aimed to investigate potential predictors of tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dfb510d027064b281392ae082e15ee
https://pubmed.ncbi.nlm.nih.gov/30570548
https://pubmed.ncbi.nlm.nih.gov/30570548
Autor:
B. Lekoko, Simani Gaseitsiwe, Dorcas Maruapula, Iain J. MacLeod, Myron Essex, Madisa Mine, Christopher F. Rowley
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:1361-1366
Objectives: The aim of the study was to evaluate for the presence of drug resistance to HIV medications in treatment-naive individuals in Botswana. Methods: Two different populations were evaluated for evidence of HIV drug resistance at three differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac63040d0e8b09fb45b879aab69c8afa
https://doi.org/10.1093/jac/dkv500
https://doi.org/10.1093/jac/dkv500
Autor:
James J. Lai, Nuttada Panpradist, Guoqing Zhang, Ingrid A. Beck, Anubhav Tripathi, Rami Kantor, Chunfu Yang, Barry R. Lutz, Iain J. MacLeod, Shanmugam Saravanan, Ruth Kanthula, Lisa M. Frenkel, Michael H. Chung, Horacio A. Duarte
Publikováno v:
The Journal of infectious diseases. 216(suppl_9)
Healthcare delivery has advanced due to the implementation of point-of-care testing, which is often performed within minutes to hours in minimally equipped laboratories or at home. Technologic advances are leading to point-of-care kits that incorpora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257db97476ff4147bc24befcc972da7
https://pubmed.ncbi.nlm.nih.gov/29040621
https://pubmed.ncbi.nlm.nih.gov/29040621