Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Iain G Johnston"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 6 (2023)
AbstractMitochondrial DNA heteroplasmy samples can shed light on vital developmental and genetic processes shaping mitochondrial DNA populations. The sample means and sample variance of a set of heteroplasmy observations are typically used both to es
Externí odkaz:
https://doaj.org/article/d96a34072c8841b8929774dbd2df0a03
Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions.
Autor:
Robert C Glastad, Iain G Johnston
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010953 (2023)
Mitochondria are highly dynamic organelles, containing vital populations of mitochondrial DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures in different cells, from cell-wide reticulated networks to fragmented
Externí odkaz:
https://doaj.org/article/2d4cab5e6645420fab63ae2459813a7b
Autor:
David M Edwards, Ellen C Røyrvik, Joanna M Chustecki, Konstantinos Giannakis, Robert C Glastad, Arunas L Radzvilavicius, Iain G Johnston
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001153 (2021)
Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic "bottleneck" increases cell-to-cell varianc
Externí odkaz:
https://doaj.org/article/c95fd5f4211a4bd0b0ad59f193518b41
Autor:
Hanne Hoitzing, Payam A Gammage, Lindsey Van Haute, Michal Minczuk, Iain G Johnston, Nick S Jones
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007023 (2019)
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we u
Externí odkaz:
https://doaj.org/article/28494271e68e473383d5e00dc5b1fce6
Autor:
Alexandre de Figueiredo, MSc, Iain G Johnston, DPhil, David M D Smith, DPhil, Sumeet Agarwal, DPhil, Dr. Heidi J Larson, PhD, Dr. Nick S Jones, PhD
Publikováno v:
The Lancet Global Health, Vol 4, Iss 10, Pp e726-e735 (2016)
Background: Incomplete immunisation coverage causes preventable illness and death in both developing and developed countries. Identification of factors that might modulate coverage could inform effective immunisation programmes and policies. We const
Externí odkaz:
https://doaj.org/article/d084d28690a547679c9ec15bd066c908
Autor:
Iain G Johnston, Joerg P Burgstaller, Vitezslav Havlicek, Thomas Kolbe, Thomas Rülicke, Gottfried Brem, Jo Poulton, Nick S Jones
Publikováno v:
eLife, Vol 4 (2015)
Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA diseases.
Externí odkaz:
https://doaj.org/article/8019d712523d4708afa02fd46cc2e356
Publikováno v:
IEEE Access, Vol 12, Pp 81030-81046 (2024)
Transition graphs or transition diagrams, describing the rates and probabilities with which a system changes between discrete states, are common throughout the sciences. In many cases, parameterisations of transition graphs are inferred from differen
Externí odkaz:
https://doaj.org/article/e1f972cd7dcf4800a50567bf00109059
Publikováno v:
eLife, Vol 2 (2013)
C4 photosynthesis has independently evolved from the ancestral C3 pathway in at least 60 plant lineages, but, as with other complex traits, how it evolved is unclear. Here we show that the polyphyletic appearance of C4 photosynthesis is associated wi
Externí odkaz:
https://doaj.org/article/b8b350ad5ecb4402986550016eaca2c0
Autor:
Iain G Johnston, Bernadett Gaal, Ricardo Pires das Neves, Tariq Enver, Francisco J Iborra, Nick S Jones
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002416 (2012)
We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription, translation, stem ce
Externí odkaz:
https://doaj.org/article/82408ccaf4d2433c9af0c10e33ca99ff
Autor:
Eszter Dombi, Tony Marinaki, Paolo Spingardi, Val Millar, Nastasia Hadjichristou, Janet Carver, Iain G. Johnston, Carl Fratter, Joanna Poulton
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: In mitochondrial DNA (mtDNA) depletion syndrome (MDS), patients cannot maintain sufficient mtDNA for their energy needs. MDS presentations range from infantile encephalopathy with hepatopathy (Alpers syndrome) to adult chronic progressi
Externí odkaz:
https://doaj.org/article/442c27504d594d649cab9edffe962c10