Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Iain G Johnston"'
Publikováno v:
IEEE Access, Vol 12, Pp 81030-81046 (2024)
Transition graphs or transition diagrams, describing the rates and probabilities with which a system changes between discrete states, are common throughout the sciences. In many cases, parameterisations of transition graphs are inferred from differen
Externí odkaz:
https://doaj.org/article/e1f972cd7dcf4800a50567bf00109059
Autor:
Eszter Dombi, Tony Marinaki, Paolo Spingardi, Val Millar, Nastasia Hadjichristou, Janet Carver, Iain G. Johnston, Carl Fratter, Joanna Poulton
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: In mitochondrial DNA (mtDNA) depletion syndrome (MDS), patients cannot maintain sufficient mtDNA for their energy needs. MDS presentations range from infantile encephalopathy with hepatopathy (Alpers syndrome) to adult chronic progressi
Externí odkaz:
https://doaj.org/article/442c27504d594d649cab9edffe962c10
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 6 (2023)
AbstractMitochondrial DNA heteroplasmy samples can shed light on vital developmental and genetic processes shaping mitochondrial DNA populations. The sample means and sample variance of a set of heteroplasmy observations are typically used both to es
Externí odkaz:
https://doaj.org/article/d96a34072c8841b8929774dbd2df0a03
Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions.
Autor:
Robert C Glastad, Iain G Johnston
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 3, p e1010953 (2023)
Mitochondria are highly dynamic organelles, containing vital populations of mitochondrial DNA (mtDNA) distributed throughout the cell. Mitochondria form diverse physical structures in different cells, from cell-wide reticulated networks to fragmented
Externí odkaz:
https://doaj.org/article/2d4cab5e6645420fab63ae2459813a7b
Publikováno v:
Quantitative Plant Biology, Vol 4 (2023)
Abscisic acid (ABA) is a plant hormone well known to regulate abiotic stress responses. ABA is also recognised for its role in biotic defence, but there is currently a lack of consensus on whether it plays a positive or negative role. Here, we used s
Externí odkaz:
https://doaj.org/article/e1b7b423eef148d38271adbc94a6c02d
Autor:
Boris Pantic, Daniel Ives, Mara Mennuni, Diego Perez-Rodriguez, Uxoa Fernandez-Pelayo, Amaia Lopez de Arbina, Mikel Muñoz-Oreja, Marina Villar-Fernandez, Thanh-mai Julie Dang, Lodovica Vergani, Iain G. Johnston, Robert D. S. Pitceathly, Robert McFarland, Michael G. Hanna, Robert W. Taylor, Ian J. Holt, Antonella Spinazzola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
It has been a longstanding goal to promote the propagation of functional mitochondrial DNAs at the expense of pathological molecules in cells where the two species coexist. Here, the authors show that restricting the availability of glucose and gluta
Externí odkaz:
https://doaj.org/article/ddb6e0fbdcc044759f368cb2f07e6239
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Bioenergetic organelles—mitochondria and plastids—retain their own genomes (mtDNA and ptDNA), and these organelle DNA (oDNA) molecules are vital for eukaryotic life. Like all genomes, oDNA must be able to evolve to suit new environmental challeng
Externí odkaz:
https://doaj.org/article/19c20145ccfd48738b1263276999a20e
Autor:
Robert L. Peach, Sam F. Greenbury, Iain G. Johnston, Sophia N. Yaliraki, David J. Lefevre, Mauricio Barahona
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The intrinsic temporality of learning demands the adoption of methodologies capable of exploiting time-series information. In this study we leverage the sequence data framework and show how data-driven analysis of temporal sequences of task
Externí odkaz:
https://doaj.org/article/feaf2b62a3224a24ab940ed48afc5c8b
Publikováno v:
Frontiers in Education, Vol 7 (2022)
Bioinformatics is a highly interdisciplinary subject, with substantial and growing influence in health, environmental science and society, and is utilised by scientists from many diverse academic backgrounds. Education in bioinformatics therefore nec
Externí odkaz:
https://doaj.org/article/26d7c69fc1d848b7b42c448513019547
Publikováno v:
Quantitative Plant Biology, Vol 3 (2022)
Mitochondria in plant cells usually contain less than a full copy of the mitochondrial DNA (mtDNA) genome. Here, we asked whether mitochondrial dynamics may allow individual mitochondria to ‘collect’ a full set of mtDNA-encoded gene products over
Externí odkaz:
https://doaj.org/article/7f7e873c35944952b79869c056b592d9