An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Autor: Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176693 (2017)

Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to ab

Externí odkaz: https://doaj.org/article/ae518cca3a5a4ee6a6bf6b30edf910b8

A multi-functional imaging approach to high-content protein interaction screening.

Autor: Daniel R Matthews, Gilbert O Fruhwirth, Gregory Weitsman, Leo M Carlin, Enyinnaya Ofo, Melanie Keppler, Paul R Barber, Iain D C Tullis, Borivoj Vojnovic, Tony Ng, Simon M Ameer-Beg

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e33231 (2012)

Functional imaging can provide a level of quantification that is not possible in what might be termed traditional high-content screening. This is due to the fact that the current state-of-the-art high-content screening systems take the approach of sc

Externí odkaz: https://doaj.org/article/be7dae9c27184a5895f60efb3e0a0048

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

Autor: Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J. Bryant, Alastair D. Lamb, Boris Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy

Extension of prostate cancer beyond the primary site into the surrounding organs by local invasion or nodal metastasis is associated with poor prognosis. The emergence and evolution of cancer clones at this early stage of expansion and spread has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5536552f419f740c8133217262863860
https://doi.org/10.1101/2023.02.27.530113

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Autor: Danny Allen, Stephen J. Lockett, Ruth J. Muschel, Tamar Yechezkel, Paul Kinchesh, Boris Vojnovic, Alastair D. Lamb, Hanna T. Sjoberg, Dina Preise, Richard J. Bryant, Jens Rittscher, Ka Ho Tam, Adrian L. Harris, Ian G. Mills, Yiannis Philippou, Anette L Magnussen, Iain D. C. Tullis, Emma A Murphy, Lilach Agemy, Freddie C. Hamdy, David A. Wink, Andrea Chatrian, Avigdor Scherz, Sean Smart, Joël Lefebvre, Stuart Gilchrist, Esther Bridges, David A. Scheiblin

Publikováno v: Sjoberg, H T, Philippou, Y, Magnussen, A L, Tullis, I D C, Bridges, E, Chatrian, A, Lefebvre, J, Tam, K H, Murphy, E A, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S C, Kinchesh, P, Gilchrist, S, Allen, D P, Scheiblin, D A, Lockett, S J, Wink, D A, Lamb, A D, Mills, I G, Harris, A, Muschel, R J, Vojnovic, B, Scherz, A, Hamdy, F C & Bryant, R J 2021, ' Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer ', British Journal of Cancer, vol. 125, pp. 534-546 . https://doi.org/10.1038/s41416-021-01450-6
British Journal of Cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e332f7007516e12e8126b136968964
https://pure.qub.ac.uk/en/publications/tumour-irradiation-combined-with-vasculartargeted-photodynamic-therapy-enhances-antitumour-effects-in-preclinical-prostate-cancer(a26d16da-6c3f-41e3-84f7-b20bf56280b2).html

Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer

Autor: Stephen J. Lockett, Lilach Agemy, Joel Loefebvre, Dina Preise, Richard J. Bryant, Iain D. C. Tullis, Boris Vojnovic, Avigdor Scherz, Hanna T. Sjoberg, Adrian L. Harris, Danny Allen, Alastair D. Lamb, Anette L Magnussen, Tamar Yechezkel, Yiannis Philippou, Ruth J. Muschel, Stuart Gilchrist, Ian G. Mills, Esther Bridges, David A. Scheiblin, Freddie C. Hamdy, David A. Wink, Paul Kinchesh, Jens Rittscher, Emma A Murphy, Ka Ho Tam, Andrea Chatrian, Sean Smart

RationaleThere is an important clinical need to improve the treatment of high risk localized and locally advanced prostate cancer (PCa), and to reduce the side effects of these treatments. We hypothesized that multi-modality therapy combining radioth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40253e120aea52b374e01dcb15dda989
https://doi.org/10.1101/2020.11.26.400283