Monitoring beam charge during FLASH irradiations

Autor: Borivoj Vojnovic, Iain D. C. Tullis, Robert G. Newman, Kristoffer Petersson

Publikováno v: Frontiers in Physics, Vol 11 (2023)

In recent years, FLASH irradiation has attracted significant interest in radiation research. Studies have shown that irradiation at ultra-high dose rates (FLASH) reduces the severity of toxicities in normal tissues compared to irradiation at conventi

Externí odkaz: https://doaj.org/article/1e991257b03945a58fda1083af1e3942

An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Autor: Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176693 (2017)

Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to ab

Externí odkaz: https://doaj.org/article/ae518cca3a5a4ee6a6bf6b30edf910b8

Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer

Autor: Danny Allen, Stephen J. Lockett, Ruth J. Muschel, Tamar Yechezkel, Paul Kinchesh, Boris Vojnovic, Alastair D. Lamb, Hanna T. Sjoberg, Dina Preise, Richard J. Bryant, Jens Rittscher, Ka Ho Tam, Adrian L. Harris, Ian G. Mills, Yiannis Philippou, Anette L Magnussen, Iain D. C. Tullis, Emma A Murphy, Lilach Agemy, Freddie C. Hamdy, David A. Wink, Andrea Chatrian, Avigdor Scherz, Sean Smart, Joël Lefebvre, Stuart Gilchrist, Esther Bridges, David A. Scheiblin

Publikováno v: Sjoberg, H T, Philippou, Y, Magnussen, A L, Tullis, I D C, Bridges, E, Chatrian, A, Lefebvre, J, Tam, K H, Murphy, E A, Rittscher, J, Preise, D, Agemy, L, Yechezkel, T, Smart, S C, Kinchesh, P, Gilchrist, S, Allen, D P, Scheiblin, D A, Lockett, S J, Wink, D A, Lamb, A D, Mills, I G, Harris, A, Muschel, R J, Vojnovic, B, Scherz, A, Hamdy, F C & Bryant, R J 2021, ' Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer ', British Journal of Cancer, vol. 125, pp. 534-546 . https://doi.org/10.1038/s41416-021-01450-6
British Journal of Cancer

Background There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised PCa, which rapidly disrupts targeted tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e332f7007516e12e8126b136968964
https://pure.qub.ac.uk/en/publications/tumour-irradiation-combined-with-vasculartargeted-photodynamic-therapy-enhances-antitumour-effects-in-preclinical-prostate-cancer(a26d16da-6c3f-41e3-84f7-b20bf56280b2).html

Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer

Autor: Stephen J. Lockett, Lilach Agemy, Joel Loefebvre, Dina Preise, Richard J. Bryant, Iain D. C. Tullis, Boris Vojnovic, Avigdor Scherz, Hanna T. Sjoberg, Adrian L. Harris, Danny Allen, Alastair D. Lamb, Anette L Magnussen, Tamar Yechezkel, Yiannis Philippou, Ruth J. Muschel, Stuart Gilchrist, Ian G. Mills, Esther Bridges, David A. Scheiblin, Freddie C. Hamdy, David A. Wink, Paul Kinchesh, Jens Rittscher, Emma A Murphy, Ka Ho Tam, Andrea Chatrian, Sean Smart

RationaleThere is an important clinical need to improve the treatment of high risk localized and locally advanced prostate cancer (PCa), and to reduce the side effects of these treatments. We hypothesized that multi-modality therapy combining radioth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40253e120aea52b374e01dcb15dda989
https://doi.org/10.1101/2020.11.26.400283

A multi-functional imaging approach to high-content protein interaction screening.

Autor: Daniel R Matthews, Gilbert O Fruhwirth, Gregory Weitsman, Leo M Carlin, Enyinnaya Ofo, Melanie Keppler, Paul R Barber, Iain D C Tullis, Borivoj Vojnovic, Tony Ng, Simon M Ameer-Beg

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e33231 (2012)

Functional imaging can provide a level of quantification that is not possible in what might be termed traditional high-content screening. This is due to the fact that the current state-of-the-art high-content screening systems take the approach of sc

Externí odkaz: https://doaj.org/article/be7dae9c27184a5895f60efb3e0a0048