Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Iain Beehuat Tan"'
Autor:
Qingyuan Zhuang, Alwin Yaoxian Zhang, Ryan Shea Tan Ying Cong, Grace Meijuan Yang, Patricia Soek Hui Neo, Daniel SW Tan, Melvin LK Chua, Iain Beehuat Tan, Fuh Yong Wong, Marcus Eng Hock Ong, Sean Shao Wei Lam, Nan Liu
Publikováno v:
BMC Palliative Care, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Ex-ante identification of the last year in life facilitates a proactive palliative approach. Machine learning models trained on electronic health records (EHR) demonstrate promising performance in cancer prognostication. However,
Externí odkaz:
https://doaj.org/article/5408fd937f194a38b05c0bb53a3cb96b
Autor:
Peh Joo Ho, Iain BeeHuat Tan, Dawn Qingqing Chong, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Rajkumar Dorajoo, Jingmei Li
Publikováno v:
eLife, Vol 12 (2023)
Background: To evaluate the utility of polygenic risk scores (PRSs) in identifying high-risk individuals, different publicly available PRSs for breast (n=85), prostate (n=37), colorectal (n=22), and lung cancers (n=11) were examined in a prospective
Externí odkaz:
https://doaj.org/article/235feb946f6444f6887e060a99e8a690
Autor:
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs). Here, we study CD4+ TILs in human lung and colorectal cancers and observe tha
Externí odkaz:
https://doaj.org/article/cf73d279a12043e098c3dbbed9b3b8db
Autor:
Rachael Pung, Bernard Lin, Sebastian Maurer-Stroh, Fernanda L. Sirota, Tze Minn Mak, Sophie Octavia, Junxiong Pang, Iain Beehuat Tan, Clive Tan, Biauw Chi Ong, Alex R. Cook, The Singapore COVID-19 Outbreak Research Team, Vernon J. Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various do
Externí odkaz:
https://doaj.org/article/c0e2a4b0a27d47368c4ca59e477debe5
Autor:
Louis Jun Ye Ong, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Ramanuj DasGupta, Yi-Chin Toh
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Inter-patient and intra-tumour heterogeneity (ITH) have prompted the need for a more personalised approach to cancer therapy. Although patient-derived xenograft (PDX) models can generate drug response specific to patients, they are not sustainable in
Externí odkaz:
https://doaj.org/article/85f6517cb8294c69a16c75eda4b57a62
Autor:
Alvin Kuo Jing Teo, Yukti Choudhury, Iain Beehuat Tan, Chae Yin Cher, Shi Hao Chew, Zi Yi Wan, Lionel Tim Ee Cheng, Lynette Lin Ean Oon, Min Han Tan, Kian Sing Chan, Li Yang Hsu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract We aimed to test the sensitivity of naso-oropharyngeal saliva and self-administered nasal (SN) swab compared to nasopharyngeal (NP) swab for COVID-19 testing in a large cohort of migrant workers in Singapore. We also tested the utility of ne
Externí odkaz:
https://doaj.org/article/18cd25da9da24dfbbb962dbe29d48c54
Autor:
Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R. Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu, Biauw Chi Ong
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2141-2150 (2021)
Background: We studied humoral and cellular responses against SARS-CoV-2 longitudinally in a homogeneous population of healthy young/middle-aged men of South Asian ethnicity with mild COVID-19. Methods: In total, we recruited 994 men (median age: 34
Externí odkaz:
https://doaj.org/article/7216933f0da44ea99250b89711b9a0f1
Autor:
Alvin Kuo Jing Teo, Yukti Choudhury, Iain Beehuat Tan, Chae Yin Cher, Shi Hao Chew, Zi Yi Wan, Lionel Tim Ee Cheng, Lynette Lin Ean Oon, Min Han Tan, Kian Sing Chan, Li Yang Hsu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/cb4e26834d474d8f9f975f0db436942d
Autor:
Syed Moiz Ahmed, Priya Dharshana Ramani, Stephen Qi Rong Wong, Xiaodan Zhao, Roland Ivanyi-Nagy, Tang Choong Leong, Clarinda Chua, Zhizhong Li, Hannes Hentze, Iain BeeHuat Tan, Jie Yan, Ramanuj DasGupta, Peter Dröge
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0215696 (2019)
The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. Howe
Externí odkaz:
https://doaj.org/article/369e5b0373bd4d7c90c5113ab842ebb7
Autor:
Jeeyun Lee, Insuk Sohn, In-Gu Do, Kyoung-Mee Kim, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Tae Sung Sohn, Jae Moon Bae, Min Gew Choi, Do Hoon Lim, Byung Hoon Min, Joon Haeng Lee, Poong Lyul Rhee, Jae J Kim, Dong Il Choi, Iain Beehuat Tan, Kakoli Das, Patrick Tan, Sin Ho Jung, Won Ki Kang, Sung Kim
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90133 (2014)
Despite the benefits from adjuvant chemotherapy or chemoradiotherapy, approximately one-third of stage II gastric cancer (GC) patients developed recurrences. The aim of this study was to develop and validate a prognostic algorithm for gastric cancer
Externí odkaz:
https://doaj.org/article/f95b643e651a4a308ea530b3ef843272