Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Iain Bee Huat Tan"'
Autor:
Heng Boon Low, Zhen Lim Wong, Bangyuan Wu, Li Ren Kong, Chin Wen Png, Yik-Lam Cho, Chun-Wei Li, Fengchun Xiao, Xuan Xin, Henry Yang, Jia Min Loo, Fiona Yi Xin Lee, Iain Bee Huat Tan, Ramanuj DasGupta, Han-Ming Shen, Herbert Schwarz, Nicholas R. J. Gascoigne, Boon Cher Goh, Xiaohong Xu, Yongliang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-ass
Externí odkaz:
https://doaj.org/article/7cd1e1ed821d475f86d18b8927eabe0d
Autor:
Joo-Leng Low, Weina Du, Tenzin Gocha, Gokce Oguz, Xiaoqian Zhang, Ming Wei Chen, Srdan Masirevic, Daniel Guo Rong Yim, Iain Bee Huat Tan, Adaikalavan Ramasamy, Hao Fan, Ramanuj DasGupta
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102544- (2021)
Summary: Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we develop
Externí odkaz:
https://doaj.org/article/e9f8357f869441d0bb1ca3addf61bffd
Autor:
Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into
Externí odkaz:
https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d3
Autor:
Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f8ffb83b0f494741802b21338c674764
Autor:
Shuting Han, Aik Yong Chok, Daniel Yang Yao Peh, Joshua Zhi-Ming Ho, Emile Kwong Wei Tan, Si-Lin Koo, Iain Bee-Huat Tan, Johnny Chin-Ann Ong
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Microsatellite-instability-high (MSI-H) cancers form a spectrum of solid organ tumors collectively known as Lynch Syndrome cancers, occurring not only in a subset of colorectal, endometrial, small bowel, gastric, pancreatic, and biliary tract cancers
Externí odkaz:
https://doaj.org/article/03288d4610ef43ae9e8a50d8f9253d0a
Autor:
Patrick Tan, Bin Tean Teh, Jim R. Hughes, Gertrud Steger, Alexander Lezhava, David Lawrence Silver, Puay Hoon Tan, Kenneth Tou En Chang, Shang Li, Christopher Wai Sam Cheng, Iain Bee Huat Tan, Qiang Yu, Steven G. Rozen, Bryan C. Tan, Gary Loh, Jian Yuan Goh, James O. J. Davies, Swe Swe Myint, Chang Xu, Aditi Qamra, Tannistha Nandi, Joyce Suling Lin, Cassandra Zhengxuan He, Michelle Shu Wen Ng, Peiyong Guan, Ai Ping Lee-Lim, Jing Han Hong, Yue Ning Lam, Giovani Wijaya, Su Ting Tay, James Zhengzhong Qu, Yang Sun Chan, Manjie Xing, Dachuan Huang, Zhimei Li, Wen Fong Ooi, Joanna Koh, Kevin Junliang Lim, Jing Tan, Xiaosai Yao
Supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c483f4796a51a74e512b695e9ee4ed
https://doi.org/10.1158/2159-8290.22531964.v1
https://doi.org/10.1158/2159-8290.22531964.v1
Autor:
Patrick Tan, Bin Tean Teh, Jim R. Hughes, Gertrud Steger, Alexander Lezhava, David Lawrence Silver, Puay Hoon Tan, Kenneth Tou En Chang, Shang Li, Christopher Wai Sam Cheng, Iain Bee Huat Tan, Qiang Yu, Steven G. Rozen, Bryan C. Tan, Gary Loh, Jian Yuan Goh, James O. J. Davies, Swe Swe Myint, Chang Xu, Aditi Qamra, Tannistha Nandi, Joyce Suling Lin, Cassandra Zhengxuan He, Michelle Shu Wen Ng, Peiyong Guan, Ai Ping Lee-Lim, Jing Han Hong, Yue Ning Lam, Giovani Wijaya, Su Ting Tay, James Zhengzhong Qu, Yang Sun Chan, Manjie Xing, Dachuan Huang, Zhimei Li, Wen Fong Ooi, Joanna Koh, Kevin Junliang Lim, Jing Tan, Xiaosai Yao
Supplementary methods. Supplementary Figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3570da660e6b68b2d7d361cabd4ad3
https://doi.org/10.1158/2159-8290.22531967.v1
https://doi.org/10.1158/2159-8290.22531967.v1
Autor:
Patrick Tan, Khay Guan Yeoh, Jeanie Wu, Ming-Hui Lee, David Wai-Meng Tai, Matthew C.H. Ng, Hyun Cheol Chung, Minkyu Jung, Hyo-Song Kim, Chee-Seng Tan, Asim Shabbir, Jimmy Bok-Yan So, Raghav Sundar, Bernadette Reyna Asuncion, Shi-Hui Tan, Vivien Koh, Nicholas L. Syn, Su-Pin Choo, Iain Bee-Huat Tan, Sun Young Rha, Wei Peng Yong
3G study protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d76726e3b0f81750a5aca82fa967be6
https://doi.org/10.1158/1078-0432.22474659.v1
https://doi.org/10.1158/1078-0432.22474659.v1
Autor:
Faith Sze Ee Ng, Guat Hwa Low, See Boon Tay, Han Jieh Tey, Fun Loon Leong, Choon Hua Thng, Iain Bee Huat Tan, Ryan Shea Ying Cong Tan
Purpose To develop a Natural Language Processing (NLP) pipeline with the ability to determine the histological subtype and site of a patient’s cancer from pathology reports. Methods A Spark NLP-based deep learning model pipeline was developed to pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21dca3121f2498fadeca8be01cfcd000
https://doi.org/10.21203/rs.3.rs-2115286/v1
https://doi.org/10.21203/rs.3.rs-2115286/v1
Autor:
Hae-Ock, Lee, Yourae, Hong, Hakki Emre, Etlioglu, Yong Beom, Cho, Valentina, Pomella, Ben, Van den Bosch, Jasper, Vanhecke, Sara, Verbandt, Hyekyung, Hong, Jae-Woong, Min, Nayoung, Kim, Hye Hyeon, Eum, Junbin, Qian, Bram, Boeckx, Diether, Lambrechts, Petros, Tsantoulis, Gert, De Hertogh, Woosung, Chung, Taeseob, Lee, Minae, An, Hyun-Tae, Shin, Je-Gun, Joung, Min-Hyeok, Jung, Gunhwan, Ko, Pratyaksha, Wirapati, Seok Hyung, Kim, Hee Cheol, Kim, Seong Hyeon, Yun, Iain Bee Huat, Tan, Bobby, Ranjan, Woo Yong, Lee, Tae-You, Kim, Jung Kyoon, Choi, Young-Joon, Kim, Shyam, Prabhakar, Sabine, Tejpar, Woong-Yang, Park
Publikováno v:
Nature genetics. 52(6)
Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment.