Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Iain B Styles"'
Autor:
Rosemary A Bamford, Zheng-yun Zhao, Neil A Hotchin, Iain B Styles, Gerard B Nash, James H R Tucker, Roy Bicknell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95097 (2014)
Förster resonance energy transfer (FRET) technology relies on the close proximity of two compatible fluorophores for energy transfer. Tagged (Cy3 and Cy5) complementary DNA strands forming a stable duplex and a doubly-tagged single strand were shown
Externí odkaz:
https://doaj.org/article/23aa865591bc45d09f4e17ec94de7e68
Publikováno v:
Biological Imaging, Vol 3 (2023)
This study aimed to expand our understanding of myelin basic protein (MBP), a key component of central nervous system myelin, by developing a protocol to track and quantifying individual MBP particles during oligodendrocyte (OL) differentiation. MBP
Externí odkaz:
https://doaj.org/article/1caef5eabfd74c999b7ce7cc2bb67cb9
Autor:
Mireia Jiménez‐Rosés, Bradley Angus Morgan, Maria Jimenez Sigstad, Thuy Duong Zoe Tran, Rohini Srivastava, Asuman Bunsuz, Leire Borrega‐Román, Pattarin Hompluem, Sean A. Cullum, Clare R. Harwood, Eline J. Koers, David A. Sykes, Iain B. Styles, Dmitry B. Veprintsev
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug discovery is to understand what determines the agonism or antagonism of ligands that bind them. Ligands exert their act
Externí odkaz:
https://doaj.org/article/8c395ffb80f645bb9233171b8236b0df
Autor:
Jeremy A. Pike, Victoria A. Simms, Christopher W. Smith, Neil V. Morgan, Abdullah O. Khan, Natalie S. Poulter, Iain B. Styles, Steven G. Thomas
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 54-58 (2021)
The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segm
Externí odkaz:
https://doaj.org/article/222a62998c644c59bb42c5bc19d835a7
Autor:
Daniel Rueckert, Xi Jia, Linlin Shen, Alexander Thorley, Wei Chen, Huaqi Qiu, Antonio de Marvao, Jinming Duan, Iain B. Styles, Ales Leonardis, Declan P. O'Regan, Hyung Jin Chang
Publikováno v:
IEEE Transactions on Medical Imaging. 41:199-212
Data-driven deep learning approaches to image registration can be less accurate than conventional iterative approaches, especially when training data is limited. To address this whilst retaining the fast inference speed of deep learning, we propose V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f7e47f1278b5826bd8abf9eb24bc31
https://doi.org/10.1109/tmi.2021.3108881
https://doi.org/10.1109/tmi.2021.3108881
Autor:
Eva Illes-Toth, Christopher J. Stubbs, Emma K. Sisley, Jeddidiah Bellamy-Carter, Anna L. Simmonds, Todd H. Mize, Iain B. Styles, Richard J. A. Goodwin, Helen J. Cooper
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(7)
Liquid extraction surface analysis (LESA) coupled to native mass spectrometry (MS) presents unique analytical opportunities due to its sensitivity, speed, and automation. Here, we examine whether this tool can be used to quantitatively probe protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c040622aab221eb88b678d716d50c30f
https://pubmed.ncbi.nlm.nih.gov/35675480
https://pubmed.ncbi.nlm.nih.gov/35675480
Publikováno v:
Journal of the American Society for Mass Spectrometry
The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae) represent clinically important bacterial species that are responsible for most hospit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ac8eb54b78872e0f7c0b38aab4f286
http://europepmc.org/articles/PMC8176453
http://europepmc.org/articles/PMC8176453
Publikováno v:
Chemical Science
RNA targeting is an exciting frontier for drug design. Intriguing targets include functional RNA structures in structurally-conserved untranslated regions (UTRs) of many lethal viruses. However, computational docking screens, valuable in protein stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f806ad64732b44510b18430b8187d8
https://doi.org/10.1039/d1sc00933h
https://doi.org/10.1039/d1sc00933h
Publikováno v:
Journal of the American Society for Mass Spectrometry
We have previously demonstrated native liquid extraction surface analysis (LESA) mass spectrometry imaging of small intact proteins in thin tissue sections. We also showed calculation of collision cross sections for specific proteins extracted from d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90c7936e103719b8d7d7ef4d63d4776
http://europepmc.org/articles/PMC7147347
http://europepmc.org/articles/PMC7147347
Autor:
Jim Hughes, Iain B. Styles, Susan E. Abbatiello, Rian L. Griffiths, Helen J. Cooper, Michael W. Belford
Publikováno v:
Analytical Chemistry
The benefits of high field asymmetric waveform ion mobility spectrometry (FAIMS) for mass spectrometry imaging of intact proteins in thin tissue sections have been demonstrated previously. In those works, a planar FAIMS device coupled with a Thermo E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db90edb18bee9436a910da0ca166f67c
https://doi.org/10.1021/acs.analchem.9b05124
https://doi.org/10.1021/acs.analchem.9b05124