Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Iain A. Eaves"'
Autor:
Karen Tait, Stephen C. L. Gough, John A. Todd, Iain A. Eaves, Joanne M. Heward, Stephen Sawcer, A. H. Barnett, Melanie Maranian, Hywel Snook, Jayne A. Franklyn, Alastair Compston, J. E. Collins
Publikováno v:
Diabetic Medicine. 21:267-270
Aims The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5′ upstream of the insulin (INS) and insulin-like growth factor (IGF2) genes on chromosome 11p15. The function of the VNTR is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebdb1018da60802b26b3b42e4a319a97
https://doi.org/10.1111/j.1464-5491.2004.01129.x
https://doi.org/10.1111/j.1464-5491.2004.01129.x
Autor:
J. Fred Hess, Rebecca C.J. Twells, Benedicte A. Lie, Philippa Carr, Michael S. Phillips, Riitta Veijola, Matthew Gilbey, Sarah Nutland, Joanna M. M. Howson, John A. Todd, Yusuke Nakagawa, Gillian C.L. Johnson, Edward Gregory, Jennifer Masters, Amanda Kingsnorth, Heather J. Cordell, Matthew Bright, Iain A. Eaves, Charles A. Mein, Michael L. Metzker, William Y.S. Wang, Helen E. Rance, David Clayton, Hywel Snook
Publikováno v:
Genome Research. 13:845-855
Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in “LD blocks,” interspersed by apparent “hot spots” of recombination. Previously, we cloned and physically c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146d11c7bd960a46f8160ee111cf164c
https://doi.org/10.1101/gr.563703
https://doi.org/10.1101/gr.563703
Autor:
Paul A. Lyons, Iain A. Eaves, Richard Glynne, Linda S. Wicker, Ghassan Ghandour, John A. Todd, Laurence B. Peterson
Publikováno v:
Genome Research. 12:232-243
Combining congenic mapping with microarray expression profiling offers an opportunity to establish functional links between genotype and phenotype for complex traits such as type 1 diabetes (T1D). We used high-density oligonucleotide arrays to measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa607a01a011583d7f62842da22b6e6
https://doi.org/10.1101/gr.214102
https://doi.org/10.1101/gr.214102
Autor:
John A. Todd, Rachael A. Barber, Jaakko Tuomilehto, Iain A. Eaves, Sarah Nutland, Tony R. Merriman, Francesco Cucca, Eva Tuomilehto-Wolf
Publikováno v:
Nature Genetics. 25:320-323
The choice of which population to study in the mapping of common disease genes may be critical. Isolated founder populations, such as that found in Finland, have already proved extremely useful for mapping the genes for specific rare monogenic disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0d371be4d136b8f3e9cd4449307a5aa
https://doi.org/10.1038/77091
https://doi.org/10.1038/77091
Autor:
Roger D. Cox, Rebecca C.J. Twells, John A. Todd, Erik Thorsby, Marilyn E. Merriman, Steve Bain, Jaakko Tuomilehto, Tony R. Merriman, Eva Tuomilehto-Wolf, Patrick A. C. Danoy, Patricia A. McKinney, C Muxworthy, Kjersti S. Rønningen, Francesco Cucca, Jørn Nerup, Dag E. Undlien, Iain A. Eaves, C. Ionesco-Tirgoviste, Julian P.H. Shield, Geir Joner, Flemming Pociot, Kara Hunter, J. David Baum
Publikováno v:
Human Molecular Genetics. 7:517-524
Allelic association methods based on increased transmission of marker alleles will have to be employed for the mapping of complex disease susceptibility genes. However, because the extent of association of single marker alleles with disease is a func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6251fb28d7e0b6df2dcef4ff5af1870b
https://doi.org/10.1093/hmg/7.3.517
https://doi.org/10.1093/hmg/7.3.517
Autor:
Iain A, Eaves, Linda S, Wicker, Ghassan, Ghandour, Paul A, Lyons, Laurence B, Peterson, John A, Todd, Richard J, Glynne
Publikováno v:
Genome research. 12(2)
Combining congenic mapping with microarray expression profiling offers an opportunity to establish functional links between genotype and phenotype for complex traits such as type 1 diabetes (T1D). We used high-density oligonucleotide arrays to measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dcb35ca9891287d3bcd69c410bfe168
https://pubmed.ncbi.nlm.nih.gov/11827943
https://pubmed.ncbi.nlm.nih.gov/11827943
Autor:
Gianfranco Di Genova, Hironori Ueda, Gillian C.L. Johnson, Stephen C. L. Gough, David Clayton, Iain A. Eaves, Annabel N. Smith, Jaakko Tuomilehto, Laura Esposito, Phillipa Carr, Heather J. Cordell, Rebecca C.J. Twells, Bryan J. Barratt, Sarah Nutland, Joanne M. Heward, Helen Stevens, Eva Tuomilehto-Wolf, Wil Hughes, John A. Todd, Frank Dudbridge, Felicity Payne
Publikováno v:
Nature genetics. 29(2)
Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping effort and cost of producing such an LD map could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319d543c1c73a800d8b480d8904dcaa2
http://ora.ox.ac.uk/objects/uuid:a712d12e-2960-407e-96bb-1a6730f4169b
http://ora.ox.ac.uk/objects/uuid:a712d12e-2960-407e-96bb-1a6730f4169b
Autor:
Anette-G. Ziegler, John A. Todd, Karin M. Ferber, Iain A. Eaves, Peter Forster, Sumit Bhattacharyya, Simon T. Bennett, Amanda Wilson, David A. Ehrmann, Bernd Brinkmann
Publikováno v:
Nature Genetics. 22:324-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2f1fb24a185bd137bcdd2a60ed36ff
https://doi.org/10.1038/11890
https://doi.org/10.1038/11890
Autor:
Miriam Loddo, Michael B. Whalen, John A. Todd, Patrizia Zavattari, Rosanna Lampis, Francesco Cucca, Annapaola Mulargia, Giuseppe Mastio, Iain A. Eaves, Elisabetta Deidda
Publikováno v:
Scopus-Elsevier
Linkage disequilibrium (LD) mapping of disease genes is complicated by population- and chromosome-region-specific factors. We have analysed demographic factors by contrasting intermarker LD results obtained in a large cosmopolitan population (UK), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c68fdd0dcf2d680a34a484deb7035b
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034642291&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034642291&partnerID=MN8TOARS
Autor:
Iain A. Eaves, Fleming Pociot, Francesca Coraddu, C. Ionesco-Tirgoviste, John A. Todd, Stephen Sawcer, Johan Jirholt, Kjersti S. Rønningen, Alastair Compston, Francesco Cucca, Tony R. Merriman, Rikard Holmdahl, Argyrios N. Theofilopoulos, Dwight H. Kono, Dag E. Undlien, Maria Giovanna Marrosu, Steve Laval, Steve Bain, Simon Broadley, Patrick Danoy, Constantin Polychronakos, Heather J. Cordell, Julian P.H. Shield, Chaim O. Jacob, Raffaella Buzzetti, Rachael A. Barber, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Paul Wordsworth, Jørn Nerup, Jane Shatford
Publikováno v:
Scopus-Elsevier
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a genetic association with the major histocompatibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa91e5108281b273583f6ccff113fee
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035152589&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035152589&partnerID=MN8TOARS