Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Iain, Mcinnes"'
Autor:
Meredith Leston, José Ordóñez-Mena, Mark Joy, Simon de Lusignan, Richard Hobbs, Iain McInnes, Lennard Lee
Publikováno v:
JMIR Research Protocols, Vol 13, p e56271 (2024)
BackgroundGlobally, there are marked inconsistencies in how immunosuppression is characterized and subdivided into clinical risk groups. This is detrimental to the precision and comparability of disease surveillance efforts—which has negative impli
Externí odkaz:
https://doaj.org/article/df23b0fa762a47d9a4cf616667b5cb08
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
This Perspective presents the potential of the Small Intestinal Axis, a sub-division of the Gut-immune Axis, to modulate systemic inflammation based on sensing contents of the gut lumen. Gut mucosal immunity regulates tolerance to food and gut conten
Externí odkaz:
https://doaj.org/article/821e647d816a4202813fbe8b3147ea6f
Autor:
Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs
Publikováno v:
BMC Rheumatology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract Background Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseas
Externí odkaz:
https://doaj.org/article/7bbdfdc9383c46daab23a559ec6892ed
Autor:
Catriona T. Prendergast, Robert A. Benson, Hannah E. Scales, Caio Santos Bonilha, John J. Cole, Iain McInnes, James M. Brewer, Paul Garside
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Mechanisms governing entry and exit of immune cells into and out of inflamed joints remain poorly understood. We sought herein to identify the key molecular pathways regulating such migration. Using murine models of inflammation in conjunction with m
Externí odkaz:
https://doaj.org/article/5d1175430835444c926fbbd904727585
Autor:
Kevin G Blyth, Stefan Siebert, Iain McInnes, Malcolm Sim, Martin Shaw, Tara Quasim, Lisa Gemmell, Pamela MacTavish, Helen Devine, Joanne McPeake, Mark Henderson, Varun Sharma, Kathryn Puxty, Gillian Fleming, Justine Griffin, Pauline Grose, Philip Henderson, Lucy Hogg, Kirstin King, Peter O'Brien, Callum Rainey, Laura Strachan
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Background There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients.Methods We conducted a multicentre observational cohort
Externí odkaz:
https://doaj.org/article/0b8ffbf1e45e4db996e5efc45c8b6945
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 12 (2020)
Currently, there is a growing interest in Janus kinase (JAK) intracellular signalling since targeted inhibitors against these pathways are proving effective in the treatment of a range of immune-mediated diseases, such as rheumatoid arthritis (RA), p
Externí odkaz:
https://doaj.org/article/52f5b942219f444688ee559245c6a927
Publikováno v:
Rheumatology. 62
Background/Aims Bimekizumab (BKZ) is a humanised monoclonal IgG1 antibody that acts by selectively inhibiting IL-17F in addition to IL-17A and has demonstrated clinical efficacy vs placebo (PBO) in both joint and skin outcomes in patients with active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9696ab5f84592449a6e292164f47e4
https://doi.org/10.1093/rheumatology/kead104.212
https://doi.org/10.1093/rheumatology/kead104.212
Autor:
Dennis McGonagle, Arthur Kavanaugh, Iain McInnes, Lars-Erik Kristensen, Joseph F Merola, Bruce E Strober, Jeffrey R Lisse, Jennifer Pustizzi, Christophe Sapin, Rebecca Bolce, Christopher Ritchlin
Publikováno v:
Rheumatology. 62
Background/Aims Psoriatic nail disease is intimately linked to adjacent distal interphalangeal joint (DIP) disease, and it is important to ascertain whether DIP-nail complex behaves differently under different biological therapies. The aim of this an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ddd3e5692a9e815c3fb3ce3433d25
https://doi.org/10.1093/rheumatology/kead104.210
https://doi.org/10.1093/rheumatology/kead104.210
Autor:
Faye A. H. Cooles, Amy E. Anderson, Andrew Skelton, Arthur G. Pratt, Mariola S. Kurowska-Stolarska, Iain McInnes, Catharien M. U. Hilkens, John D. Isaacs
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
ObjectiveDendritic cells (DCs) are key orchestrators of immune function. To date, rheumatoid arthritis (RA) researchers have predominantly focused on a potential pathogenic role for CD1c+ DCs. In contrast, CD141+ DCs and plasmacytoid DCs (pDCs) have
Externí odkaz:
https://doaj.org/article/da5aeeec66c84f71ac10c16b997e9e0a
Publikováno v:
European Medical Journal Rheumatology, Vol 2, Iss 1, Pp 55-64 (2015)
Prof Philip Mease introduced psoriatic arthritis (PsA) with a particular emphasis on disease symptoms and an update on the status of current disease management. Erik Lubberts described the interleukin (IL)-17 pathway and its role in the pathogenesis
Externí odkaz:
https://doaj.org/article/8bd03c4b9c3c49a4be039540bef4ff24