Výsledky vyhledávání - "Iago Méndez-López"

Progressive Mitochondrial SOD1G93A Accumulation Causes Severe Structural, Metabolic and Functional Aberrations through OPA1 Down-Regulation in a Mouse Model of Amyotrophic Lateral Sclerosis

Autor: Juan Fernando Padín, Tobias Engel, Antonio G. García, Iago Méndez-López, Francisco J. Sancho-Bielsa

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8194, p 8194 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 15; Pages: 8194

In recent years, the “non-autonomous motor neuron death” hypothesis has become more consolidated behind amyotrophic lateral sclerosis (ALS). It postulates that cells other than motor neurons participate in the pathology. In fact, the involvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3090b266780f446b2da013d730976bd9
http://europepmc.org/articles/PMC8347639

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Chronic resveratrol consumption prevents hypertension development altering electrophysiological currents and Ca

Autor: Guilherme Henrique Souza, Bomfim, Diego Castro, Musial, Iago, Méndez-López, Aron, Jurkiewicz, Neide Hyppolito, Jurkiewicz, Juan Fernando, Padín, Antonio G, García

Publikováno v: Cellular signalling. 76

Resveratrol (RESV) is one of the most abundant polyphenol-stilbene compounds found in red wine with well-established cardioprotective and antihypertensive effects. Hyperactivity of the sympathoadrenal axis seems to be one of the major contributing fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b68733470fcb4ff750f1419ea63fce81
https://pubmed.ncbi.nlm.nih.gov/33075487

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The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Autor: Luis Gandía, Victoria Maneu, Antonio G. García, Ricardo de Pascual, María F. Cano-Abad, Iago Méndez-López, Cristina Ruiz-Ruiz, Cristóbal de los Ríos, Francesco Calzaferri, Antonio M. G. de Diego

Publikováno v: Medicinal Research Reviews
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in Alzheimer's disease (AD) in which all proposed treatments investigated in murine models have failed during clinical trials (CTs). Thus, novel therapeutic strategies rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe973abf104824aeb1864debb2d839
https://hdl.handle.net/10486/697548

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Altered mitochondrial function, calcium signaling, and catecholamine release in chromaffin cells of diabetic and SHR rats

Autor: Aron Jurkiewicz, Juan Fernando Padín, Regiane Miranda-Ferreira, Antonio G. García, Diego Castro Musial, Juan Alberto Arranz-Tagarro, Iago Méndez-López, Guilherme Henrique Souza Bomfim, Neide H. Jurkiewicz

Publikováno v: European Journal of Pharmacology. 815:416-426

Comorbidity of diabetes and hypertension is frequent. Here, we have performed a comparative study in three animal models namely, normotensive Wistar Kyoto (WKY) rats, streptozotocin-induced diabetic rats (STZ), and spontaneously hypertensive rats (SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949bc8e0ba66878e7677e75983ec3e89
https://doi.org/10.1016/j.ejphar.2017.09.045

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Altered mitochondrial function, capacitative calcium entry and contractions in the aorta of hypertensive rats

Autor: Juan Alberto Arranz-Tagarro, J. Fernando Padín, Juan P. Velasco-Martín, Diego Castro Musial, Guilherme Henrique Souza Bomfim, Aron Jurkiewicz, Iago Méndez-López, Javier Regadera, Neide H. Jurkiewicz, Antonio G. García

Publikováno v: Journal of Hypertension. 35:1594-1608

Objective It has been suggested that Ca entry through store-operated Ca channels (SOCs) is regulated by a dynamic interplay between the endoplasmic reticulum Ca stores and the mitochondria. These relationships drive the activation and inactivation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41049cfaf0bb2c9ee41d9a0f902bac4f
https://doi.org/10.1097/hjh.0000000000001360

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The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial Na+/Ca2+exchanger

Autor: Cristóbal de los Ríos, Carmen Martínez-Ramírez, Luis Gandía, Antonio G. García, Mayte Montero, J. Fernando Padín-Nogueira, Iago Méndez-López, Angela López-Gil, Carmen Nanclares

Publikováno v: The Journal of Physiology. 595:2129-2146

KEY POINTS Upon repeated application of short ACh pulses to C57BL6J mouse chromaffin cells, the amperometrically monitored secretory responses promptly decayed to a steady-state level of around 25% of the initial response. A subsequent K+ pulse, howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::189551ea838db1f651b0716f0509b08f
https://doi.org/10.1113/jp273339

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Adrenergic chromaffin cells are adrenergic even in the absence of epinephrine

Autor: J. Fernando Padín, José-David Machado, Judith Estévez-Herrera, Iago Méndez-López, Steven N. Ebert, Leandro Castañeyra, Ricardo Borges, Agustín Castañeyra, Natalia Domínguez, Ayoze González-Santana, Rebeca Baz-Dávila

Publikováno v: Journal of neurochemistryReferences. 152(3)

Adrenal chromaffin cells release epinephrine (EPI) and norepinephrine (NE) into the bloodstream as part of the homeostatic response to situations like stress. Here we utilized EPI-deficient mice generated by knocking out (KO) the phenylethanolamine N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f365b317afe132f2c91918777da07f9
https://pubmed.ncbi.nlm.nih.gov/31677273

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Chronic resveratrol consumption prevents hypertension development altering electrophysiological currents and Ca2+ signaling in chromaffin cells from SHR rats

Autor: Juan Fernando Padín, Antonio G. García, Neide H. Jurkiewicz, Guilherme Henrique Souza Bomfim, Iago Méndez-López, Aron Jurkiewicz, Diego Castro Musial

Publikováno v: Cellular Signalling. 76:109811

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b920e21f6a7f6388b942cbd87254cdc
https://doi.org/10.1016/j.cellsig.2020.109811

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Faster kinetics of quantal catecholamine release in mouse chromaffin cells stimulated with acetylcholine, compared with other secretagogues

Autor: Antonio G. García, Angela López-Gil, Carmen Martínez-Ramírez, Enrique Calvo-Gallardo, Iago Méndez-López, Juan Fernando Padín

Publikováno v: Journal of Neurochemistry. 139:722-736

Adrenal chromaffin cells (CCs) have been used extensively in studies aimed at revealing the intricacies of the Ca2+ -dependent early and late steps of regulated exocytosis. They have also served as invaluable models to study the kinetics of single-ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047668f81b26af239a3ed14f7030c5ab
https://doi.org/10.1111/jnc.13849

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143 Stimulated glycolysis is able to maintain ATP levels and motility of bull spermatozoa submitted to mitochondrial depolarisation

Autor: Antonio G. García, N. Montez, Iago Méndez-López, Juan-Fernando Padín, J. D. A. Losano, Marcilio Nichi, D. S. R. Angrimani, V. H. Barnabe

Publikováno v: Reproduction, Fertility and Development. 32:198

Studies have reported the importance of mitochondria in sperm metabolism. However, for some species, glycolysis appears to be as essential as oxidative phosphorylation in sperm physiology. On the other hand, these mechanisms have not been fully eluci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaa8be37b3c0185ed4ada699872ce514
https://doi.org/10.1071/rdv32n2ab143

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