Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Iafa, Keydar"'
Autor:
Maya Golan, Amnon Hizi, James H. Resau, Neora Yaal-Hahoshen, Hadar Reichman, Iafa Keydar, Ilan Tsarfaty
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 521-533 (2008)
A reverse transcriptase (RT) cDNA, designated HERV-K-T47D-RT, was isolated from a hormonally treated human breast cancer cell line. The protein product putative sequence is 97% identical to the human endogenous HERV-K retroviral sequences. Recombinan
Externí odkaz:
https://doaj.org/article/9f057ede973c4383ae5032a14d66f34b
Autor:
Joseph Z. Zaretsky, Michael A. McGuckin, Pavlos Neophytou, His-Hsien Lin, Merav Yoeli, Iafa Keydar, Stefanie J. Williams, Ravit Ziv, Amos Baruch, Daniel H. Wreschner, Martin Stacey, Nechama I. Smorodinsky, Siamon Gordon, Liron Okun
Publikováno v:
Protein Science. 11:698-706
A mechanism is described whereby one and the same gene can encode both a receptor protein as well as its specific ligand. Generation of this receptor-ligand partnership is effected by proteolytic cleavage within a specific module located in a membran
Autor:
Marcelo Ehrlich, Efrat Cohen-Hillel, Neora Yaal-Hahoshen, Elina Azenshtein, Larisa Ryvo, Leonor Leider-Trejo, Alex Shtabsky, Iafa Keydar, Gali Soria, Tsipi Meshel, Sima Shina, Adit Ben-Baruch
Publikováno v:
Cytokine. 44:191-200
The chemokines RANTES (CCL5) and MCP-1 (CCL2) were suggested to contribute, independently, to breast malignancy. In the present study, we asked if the two chemokines are jointly expressed in clinical samples of breast cancer patients, and do they int
Publikováno v:
Journal of Immunological Methods. 321:41-59
Targeted therapy encompasses a wide variety of different strategies, which can be divided into direct or indirect approaches. Direct approaches target tumor-associated antigens by monoclonal antibodies (mAbs) binding to the relevant antigens or by sm
Autor:
Joseph F. Grosso, Nechama Smorodinski, Lynn M. Herbert, Daniel H. Wreschner, Mantley Dorsey, Diana M. Lopez, Iafa Keydar, Tihui Fu, Mabel A. Cejas
Publikováno v:
Cancer Research. 64:8077-8084
Implantation of DA-3 mammary tumor cells into BALB/c mice results in tumor growth, metastatic lesions, and death. These cells were transfected with genes encoding for either the transmembrane (DA-3/TM) or secreted (DA-3/sec) form of human mucin 1 (MU
Publikováno v:
Journal of Biological Chemistry. 276:33711-33720
In this report, we analyzed the expression and kinase activities of Csk and CHK kinases in normal breast tissues and breast tumors and their involvement in HRG-mediated signaling in breast cancer cells. Csk expression and kinase activity were abundan
Autor:
Ilan G. Ron, Shuli Greenstein, Orit Sagi-Assif, Merav Yoeli, Ella Harness, Mor-li Hartman, Yair Aderet, Yona Stadler, Daniel H. Wreschner, Mordechai Weiss, Amos Baruch, Margalit Yaakubovits, Nechama I. Smorodinsky, Iafa Keydar
Publikováno v:
International Journal of Cancer. 82:256-267
The products of the MUC1 gene are known to be highly expressed in human breast cancer cells. The best characterized MUC1 protein is a polymorphic, type 1 transmembrane molecule containing a large extracellular domain composed primarily of a variable
Publikováno v:
Journal of Biological Chemistry. 273:4065-4072
Substantial evidence exists supporting direct roles for ErbB-2/neu and Src kinase activation in breast cancer. The Csk homologous kinase (CHK) is a recently identified tyrosine kinase which, like Csk, phosphorylates the C-terminal tyrosine of Src kin
Autor:
Sheila Zrihan-Licht, Mordechai Weiss, Matti Burstein, Shulamit Greenstein, Mor-li Hartmann, Amos Baruch, Daniel H. Wreschner, Nechama I. Smorodinsky, Iafa Keydar
Publikováno v:
International Journal of Cancer. 71:741-749
The human MUC1 gene expresses at least 2 type 1 membrane proteins: MUC1/REP, a polymorphic high m.w. MUC1 glycoprotein often highly expressed in breast cancer tissues and containing a variable number of tandem 20 amino acid repeat units, and the MUC1
Autor:
Marvin S. Reitz, Brynmor A. Watkins, Simona Fiorentini, Iafa Keydar, Ewa Matczak, Robert C. Gallo
Publikováno v:
Immunotechnology. 3:45-59
Background: Mucl-H23 is a cell surface mucin that is expressed on normal breast luminal epithelial cells and over-expressed in most breast tumors. In addition, Muc-1 expressed by malignant cells is glycosylated differently than Muc-1 expressed by nor