Alternative Analysis Methods for Time to Event Endpoints under Non-proportional Hazards: A Comparative Analysis

Autor: Lin, Ray S., Lin, Ji, Roychoudhury, Satrajit, Anderson, Keaven M., Hu, Tianle, Huang, Bo, Leon, Larry F, Liao, Jason JZ, Liu, Rong, Luo, Xiaodong, Mukhopadhyay, Pralay, Qin, Rui, Tatsuoka, Kay, Wang, Xuejing, Wang, Yang, Zhu, Jian, Chen, Tai-Tsang, Iacona, Renee, Group, Cross-Pharma Non-proportional Hazards Working

Publikováno v: Statistics in Biopharmaceutical Statistics 2020

The log-rank test is most powerful under proportional hazards (PH). In practice, non-PH patterns are often observed in clinical trials, such as in immuno-oncology; therefore, alternative methods are needed to restore the efficiency of statistical tes

Externí odkaz: http://arxiv.org/abs/1909.09467

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Chapter 34 - Design of clinical development programs

Autor: Gibbs, Megan A., Hamren, Bengt, Boulton, David W., Tomkinson, Helen, Iacona, Renee

Publikováno v: In Atkinson's Principles of Clinical Pharmacology Edition: Fourth Edition. 2022:653-679

Alternative Analysis Methods for Time to Event Endpoints Under Nonproportional Hazards: A Comparative Analysis

Autor: Lin, Ray S., Lin, Ji, Roychoudhury, Satrajit, Anderson, Keaven M., Hu, Tianle, Huang, Bo, Leon, Larry F, Liao, Jason JZ, Liu, Rong, Luo, Xiaodong, Mukhopadhyay, Pralay, Qin, Rui, Tatsuoka, Kay, Wang, Xuejing, Wang, Yang, Zhu, Jian, Chen, Tai-Tsang, Iacona, Renee, Group, Cross-Pharma Non-proportional Hazards Working

The log-rank test is most powerful under proportional hazards (PH). In practice, non-PH patterns are often observed in clinical trials, such as in immuno-oncology; therefore, alternative methods are needed to restore the efficiency of statistical tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9596b967c12a3a521d10d601d91db7c6

Contributors

Autor: Abernethy, Darrell R., Agoram, Balaji, Allen, John M., Arnold, Mark E., Atkinson, Arthur J., Jr., Bateman, Thomas J., Bergman, Kimberly, Booth, Brian, Boulton, David W., Branch, Robert A., Burckart, Gilbert J., Buschmann, Mary, Carmichael, Owen, Chamberlain, Christine, Chen, Ligong, Daniels, Charles E., Das, Promi, Delfino, Jana G., Van Den Anker, John N., Dreisbach, Albert W., Dyszel, Michael, Earp, Justin C., ElZarrad, M. Khair, Enogieru, Osatohanmwen J., Fletcher, Elimika Pfuma, Foster, David M., Frederiksen, Marilynn C., Galetin, Aleksandra, Garzone, Pamela D., Giacomini, Kathleen M., Gibbs, Megan A., Gilbert, Jack A, Gnjidic, Danijela, Gombar, Charles T., Grant, Denis M., Grudzinskas, Charles, Hamren, Bengt, Holford, Nicholas H.G., Huang, Shiew-Mei, Iacona, Renee, Isoherranen, Nina, Jin, Denise, Jones, Bridgette L., Kearns, Gregory L., Kortepeter, Cindy, Kunkoski, Elizabeth, Lau, S.W. Johnny, Leptak, Christopher, Lertora, Juan J.L., Lesko, Lawrence J., Liu, Jiang, Liu, Qi, Madabushi, Rajanikanth, Miller, Raymond, Mould, Diane R., Muñoz, Monica, Nolin, Thomas D., Noveck, Robert Joseph, Obach, R. Scott, Pacanowski, Michael, Paine, Mary F., Peck, Carl C., Ramamoorthy, Anuradha, Rodrigues, A. David, Rowland, Malcolm, Sahajwalla, Chandrahas G., Sahre, Martina Dagmar, Schuck, Robert N., Sharma, Khushboo, Sissung, Tristan, Stika, Catherine S., Takimoto, Chris H., Tomkinson, Helen, Uetrecht, Jack, Vicini, Paolo, Vo, Karen D., Wagner, John A., Wang, Yaning, Wang, Yow-Ming C., Wells, Peter G., Wick, Michael J., Yee, Sook Wah, Yin, Ophelia, Zgheib, Nathalie K., Zhang, Lei, Zhu, Hao

Publikováno v: In Atkinson's Principles of Clinical Pharmacology Edition: Fourth Edition. 2022:xvii-xx