Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ia F, Freĭmanis"'
Publikováno v:
Bioorganicheskaia khimiia. 22(10-11)
(+/-)-15-Fluoro-11,15-dideoxyprostaglandin E1 and its methyl and ethyl esters were synthesized. Dehydroxyfluorination reaction (+/-)-11-deoxyprostaglandin E1 esters with various reagents based on SF4 was studied. Along with the target 15-fluorides (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::896605bade62e92df4f7542c82150a82
https://pubmed.ncbi.nlm.nih.gov/9036841
https://pubmed.ncbi.nlm.nih.gov/9036841
Publikováno v:
Eksperimental'naia i klinicheskaia farmakologiia. 58(6)
We found that a number of new synthetic prostanoids caused a prominent reduction of human platelet aggregation in the in vitro experiments. Moreover, two of this agents, IOS 3933 and IOS 4732, gives storage stability. Hemoxygenase activity, metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8e241b523cc9af026c360dd1b96f8a2
https://pubmed.ncbi.nlm.nih.gov/8704613
https://pubmed.ncbi.nlm.nih.gov/8704613
Publikováno v:
Eksperimental'naia i klinicheskaia farmakologiia. 58(5)
In the experiments on rabbits it was shown, that the administration of prostanoids IOS 3933 caused a reduction of ADP- and collagen induced platelet aggregation, platelet adhesion to collagen and elevation of t-PA level. This prostanoid prevented bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a21c78e177348b2d2b802ab12e247c9d
https://pubmed.ncbi.nlm.nih.gov/8704588
https://pubmed.ncbi.nlm.nih.gov/8704588
Publikováno v:
Bioorganicheskaia khimiia. 21(5)
In order to study the physiological functions of 11-deoxyprostaglandin E1-alpha, a series of its amide derivatives with amino acids and some amines were synthesized using mixed anhydride technique. The myotropic properties of newly synthesized compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7271273efc75d6afaff332864e5cf628
https://pubmed.ncbi.nlm.nih.gov/7661863
https://pubmed.ncbi.nlm.nih.gov/7661863
Publikováno v:
Bioorganicheskaia khimiia. 18(3)
Four methods of the synthesis of model glycosides with 11-deoxyprostaglandin E1 and a connecting polymethylene chain as the aglycone are compared. Interaction of potassium salt of prostaglandin PG with omega-iodoalkylglycosides is the most promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::728cc9df66ab340efb61bdd53f1d9301
https://pubmed.ncbi.nlm.nih.gov/1524592
https://pubmed.ncbi.nlm.nih.gov/1524592
Publikováno v:
Voprosy onkologii. 36(10)
The effects of a synthetic prostaglandin E1 (PGE1) analog on colony-forming activity in agar cultures of peripheral blood and bone marrow was studied in 28 patients with chronic myeloid leukemia and 9 hematologically healthy subjects. Addition of PGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0272cddb2c73909538ac8ceef5502f8b
https://pubmed.ncbi.nlm.nih.gov/2251815
https://pubmed.ncbi.nlm.nih.gov/2251815
Publikováno v:
Farmakologiia i toksikologiia. 51(3)
(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::158a0c85714c1b0cf19b62113c836e1d
https://pubmed.ncbi.nlm.nih.gov/3410031
https://pubmed.ncbi.nlm.nih.gov/3410031
Publikováno v:
Bioorganicheskaia khimiia. 15(11)
Total synthesis of a new prostaglandin analogue, 11-deoxy-4,4-dimethyl-4-sil-prostaglandin E1, is carried out through synthesis of a silicon-containing alpha-chain precursor and a 2-substituted cyclopentenone derivative followed by their cuprate-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::904ad5f8643112699e9c65451330dd0b
https://pubmed.ncbi.nlm.nih.gov/2624593
https://pubmed.ncbi.nlm.nih.gov/2624593
Publikováno v:
Problemy endokrinologii. 30(1)
The effects of prostaglandin F2 alpha and (+/-) 11-deoxyprostaglandin E1 (DPGE) on the levels of progesterone and estradiol in the blood plasma or serum of experimental animals were studied and compared. It was found for the first time that the synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae471279b6c4ff3adf64544251416d6d
https://pubmed.ncbi.nlm.nih.gov/6709608
https://pubmed.ncbi.nlm.nih.gov/6709608
Publikováno v:
Farmakologiia i toksikologiia. 52(1)
The effect of a native synthetic prostaglandin E1 on the blood supply and basic parameters of hemodynamics in acute myocardial ischemia induced by coronary artery occlusion was studied. It was found that the preparation in doses of 5 and 10 mg/kg inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5c3615313b190d92bc8809c5354571a
https://pubmed.ncbi.nlm.nih.gov/2707415
https://pubmed.ncbi.nlm.nih.gov/2707415