Výsledky vyhledávání

Synovial Gene Signatures Associated with the Development of Rheumatoid Arthritis in At Risk Individuals: a Prospective Study

Autor: IY Choi, de Hair Mj, Paul P. Tak, van Baarsen Lg, JF Semmelink, de Jong Ta, Danielle M. Gerlag

BackgroundPrevious work has shown subtle infiltration of synovial T cells in the absence of overt synovial inflammation in individuals at risk of developing rheumatoid arthritis (RA).ObjectiveTo study the molecular changes in synovium preceding arthr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fe9eb93168387534a40fdfc962f9702
https://doi.org/10.1101/2021.04.27.440770

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Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At‐Risk and Earliest Phases of Rheumatoid Arthritis

Autor: Javier Rodríguez-Carrio, Krijn P. van Lienden, Mario Maas, Lisa G. M. van Baarsen, TH Ramwadhdoebe, Paul P. Tak, Danielle M. Gerlag, IY Choi, Teunis B. H. Geijtenbeek, JF Semmelink, J Hähnlein

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & rheumatology (Hoboken, N.J.), 69(1), 70-76. John Wiley and Sons Ltd

Objective Innate lymphoid cells (ILCs) are emerging mediators of immunity, and accumulation of inflammatory ILC populations can occur in inflammatory-mediated conditions. Since early lymph node (LN) activation has been shown in rheumatoid arthritis (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24b7af1d7dee3759ef1e9202d612e6a
https://doi.org/10.1002/art.39811

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Autonomic Dysfunction Precedes Development of Rheumatoid Arthritis: A Prospective Cohort Study

Autor: Man Wai Tang, J. Vermeij, F. A. Koopman, Paul P. Tak, Margriet J. Vervoordeldonk, J.M. Karemaker, Danielle M. Gerlag, M J H de Hair, IY Choi

Publikováno v: EBioMedicine, 6, 231-237. Elsevier BV

BackgroundHeart rate variability (HRV) is a validated method to establish autonomic nervous system (ANS) activity. Rheumatoid arthritis (RA) is accompanied by ANS imbalance. We hypothesized that ANS dysfunction may precede the development of RA, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc9d8acfad730a50a3dd3a733a38928
https://doi.org/10.1016/j.ebiom.2016.02.029

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OP0266 Synovial tissue profiling in autoantibody positive at risk individuals reveals gene signatures associated with later development of rheumatoid arthritis

Autor: P.P. Tak, L G M van Baarsen, IY Choi, JF Semmelink, Danielle M. Gerlag, M J H de Hair

Publikováno v: FRIDAY, 15 JUNE 2018.

Background Previous work has suggested subtle infiltration of synovial T cells1 in the absence of overt synovial inflammation2 in individuals at risk of developing rheumatoid arthritis (RA). Objectives To study the molecular changes in synovium prece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa507fbd0ce22cf6c0a2419b9a13b898
https://doi.org/10.1136/annrheumdis-2018-eular.5148

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Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering

Autor: Mario Maas, Teunis B. H. Geijtenbeek, TH Ramwadhdoebe, Paul P. Tak, Lisa G. M. van Baarsen, IY Choi, Danielle M. Gerlag, Ferco H. Berger, J Hähnlein, JF Semmelink

Publikováno v: Scientific reports, 8(1). Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Infections are implicated in autoimmunity. Autoantibodies are produced in lymphoid tissue where lymph node stromal cells (LNSCs) regulate lymphocyte function. Infections can alter the interaction between LNSCs and lymphocytes resulting in defective i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa170a340853770c42b475492f7fc00
https://pure.amc.nl/en/publications/distinctive-expression-of-t-cell-guiding-molecules-in-human-autoimmune-lymph-node-stromal-cells-upon-tlr3-triggering(12214ff5-4e2b-4ab5-bae6-0700624841a0).html

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Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study

Autor: Mario Maas, KI Maijer, Ae Ri Noort, Paul P. Tak, Danielle M. Gerlag, Maria J.H. de Hair, Sander W. Tas, IY Choi, Christiaan van der Leij, Katinka P.M. van Zoest

Publikováno v: Journal of rheumatology, 42(9), 1573-1581. Journal of Rheumatology

Objective.The nuclear factor-κB (NF-κB) family of transcription factors is strongly involved in synovial inflammation. We have previously shown that NF-κB–inducing kinase (NIK) is a key regulator of inflammation-induced angiogenesis in rheumatoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86991f751fe07af99a0c72ed9c221bf4
https://doi.org/10.3899/jrheum.150245

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A personalized approach to biological therapy using prediction of clinical response based on MRP8/14 serum complex levels in rheumatoid arthritis patients

Autor: Dirk Holzinger, P.M.J. Welsing, Jwj Bijlsma, S.C. Nair, F.P.J.G. Lafeber, J.M. van Laar, Danielle M. Gerlag, IY Choi, P. P. Tak, Johannes Roth

Publikováno v: PLoS ONE, 11(3). Public Library of Science
PLoS ONE, Vol 11, Iss 3, p e0152362 (2016)
PLoS ONE
PLoS ONE [E], 11(3). Public Library of Science

Objectives: Measurement of MRP8/14 serum levels has shown potential in predicting clinical response to different biological agents in rheumatoid arthritis (RA). We aimed to develop a treatment algorithm based on a prediction score using MRP8/14 measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64ebf10333ebc45f72b2a7108aaf52b
https://dspace.library.uu.nl/handle/1874/334314

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Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity

Autor: Danielle M. Gerlag, J Hähnlein, Bo J van Kuijk, Paul P. Tak, IY Choi, Leonard J van Boven, TH Ramwadhdoebe, Lisa G. M. van Baarsen

Publikováno v: Clinical & translational immunology, 5(4). Nature Publishing Group
Clinical & Translational Immunology

Although many studies are focused on auto-reactive CD4(+) T cells, the precise role of CD8(+) T cells in autoimmunity is poorly understood. The objective of this study is to provide more insight into the phenotype and function CD8(+) T cells during t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a424c74d29f51efc7a14c2d755f30689
https://pure.amc.nl/en/publications/human-lymphnode-cd8-t-cells-display-an-altered-phenotype-during-systemic-autoimmunity(64f43f80-c223-4c89-a095-5997064eb65d).html

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Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals

Autor: TH Ramwadhdoebe, KI Maijer, Maria J. H. de Hair, Elena Neumann, Paul P. Tak, IY Choi, Danielle M. Gerlag, Daniël A. C. A. D. Drop, Ulf Müller-Ladner

Publikováno v: PLoS ONE, 10(12). Public Library of Science
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144932 (2015)

Objectives We have previously shown that overweight may increase the risk of developing rheumatoid arthritis (RA) in autoantibody positive individuals. Adipose tissue could contribute to the development of RA by production of various bioactive peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f18f8611c427bd774a43017fcba72a
https://pure.amc.nl/en/publications/serum-vaspin-levels-are-associated-with-the-development-of-clinically-manifest-arthritis-in-autoantibodypositive-individuals(c9aab22b-d69d-45a0-8689-8082bce0d8eb).html

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MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis

Autor: Johannes Roth, Danielle M. Gerlag, Paul P. Tak, IY Choi, Thomas Vogl, Dirk Holzinger, M M J Herenius, Dirk Foell, Carla A. Wijbrandts, Rogier M. Thurlings

Publikováno v: Annals of the Rheumatic Diseases, 74, 3, pp. 499-505
Annals of the Rheumatic Diseases, 74, 499-505
Annals of the rheumatic diseases, 74(3), 499-505. BMJ Publishing Group

Background One-third of rheumatoid arthritis (RA) patients treated with biological therapy show lack of response. The use of predictive biomarkers to identify responders to treatment may provide guidance in optimising treatment strategies and reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67f3b4b944d665f57176608f87e3a7f
https://doi.org/10.1136/annrheumdis-2013-203923

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