Zobrazeno 1 - 10
of 30
pro vyhledávání: '"IWAT, inguinal white adipose tissue"'
Autor:
Zhengcai Ju, Lin-shan Jiang, Xunjiang Wang, Wendong Huang, Zhengtao Wang, Siming Sun, Eryun Zhang, Lili Ding, Tong Tian, Qiaoling Yang, Li Yang, Yangmeng Wang, Yingbo Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1541-1554 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Obesity and its associated complications are highly related to a current public health crisis around the world. A growing body of evidence has indicated that G-protein coupled bile acid (BA) receptor TGR5 (also known as Gpbar-1) is a potential drug t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f45516d038bca9fd9338d0a4c987b9
http://www.sciencedirect.com/science/article/pii/S2211383521001106
http://www.sciencedirect.com/science/article/pii/S2211383521001106
Autor:
Tetsuo Takehara, Tomohide Tatsumi, Ryotaro Sakamori, Kumiko Shirai, Sadatsugu Sakane, Yuki Makino, Kenji Fukumoto, Takahiro Kodama, Yuta Myojin, Hayato Hikita, Youichi Sasaki, Ryoko Yamada, Yuki Tahata, Naoki Mizutani, Shinnosuke Kudo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1683-1699 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Although nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity, the role of adipose tissue in NAFLD is not well-understood. Because autophagy has been reported to be involved in the degradation of lipid droplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1011f70ab32424b90b7306ec81dc0f77
https://doi.org/10.1016/j.jcmgh.2021.07.008
https://doi.org/10.1016/j.jcmgh.2021.07.008
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101127-(2021)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Methylglyoxal (MG) is a metabolite derived from glycolysis whose levels in the blood and tissues of patients with diabetes are higher than those of healthy individuals, suggesting that MG is associated with the development of diabetic complications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cd636c03bee25a1527d75bef884e86
http://www.sciencedirect.com/science/article/pii/S2405580821002211
http://www.sciencedirect.com/science/article/pii/S2405580821002211
Autor:
Yuting Liu, Yaqian Chen, Yuan Wang, Shuang Jiang, Weimin Lin, Yunshu Wu, Qiwen Li, Yuchen Guo, Weiqing Liu, Quan Yuan
Publikováno v:
The Journal of Biological Chemistry
DNA N6-adenine methylation (6mA), as a novel adenine modification existing in eukaryotes, shows essential functions in embryogenesis and mitochondrial transcriptions. ALKBH1 is a demethylase of 6mA and plays critical roles in osteogenesis, tumorigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f20fb816deda0f4506dca4b7557f78b
https://pubmed.ncbi.nlm.nih.gov/34922943
https://pubmed.ncbi.nlm.nih.gov/34922943
Autor:
Yuhei Oi, Keiichi Ito, Michihiro Yoshimura, Akira Yoshii, Haruka Kimura, Tomohisa Nagoshi, Yoshiro Tanaka, Toshikazu D. Tanaka, Yusuke Kashiwagi, Hirotake Takahashi
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 55, Iss, Pp 101411-(2022)
Molecular Metabolism, Vol 55, Iss, Pp 101411-(2022)
Objective Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome and drives the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transporter-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68817ad75f6f194e0db81e2d78342bdd
https://pubmed.ncbi.nlm.nih.gov/34863940
https://pubmed.ncbi.nlm.nih.gov/34863940
Autor:
Dabin Lee, Je-Yoel Cho, Sang-Hyuk Yoon, Yeo-Dae Yoon, Ki-Hoan Nam, A-Reum Nam, Sang-Mi Cho, Dong Wook Kim, Kang-Hoon Lee
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100117-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100117-(2021)
Adipose tissue affects metabolic-related diseases because it consists of various cell types involved in fat metabolism and adipokine release. CXC ligand 5 (CXCL5) is a member of the CXC chemokine family and is highly expressed by macrophages in white
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da49c0f843db52c4ce8936a83244b67
http://europepmc.org/articles/PMC8512628
http://europepmc.org/articles/PMC8512628
Autor:
Patrik Majewski, Giorgio Sesti, Almudena Gómez-Hernández, Manuel Benito, Silvia Fernandez, Vanesa Viana-Huete, Carlota Rubio-Longas, Oscar Escribano, Nuria Beneit, Andrea R. López-Pastor, Marta Letizia Hribal, Gema García-Gómez
Publikováno v:
Molecular Metabolism, Vol 31, Iss, Pp 1-13 (2020)
Molecular Metabolism
Molecular Metabolism
Objective An increase in mass and/or brown adipose tissue (BAT) functionality leads to an increase in energy expenditure, which may be beneficial for the prevention and treatment of obesity. Moreover, distinct class I PI3K isoforms can participate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95c1f433092b02d8345ccbfe40f6ea
https://doi.org/10.1016/j.molmet.2019.10.010
https://doi.org/10.1016/j.molmet.2019.10.010
Autor:
Laurie L. Baggio, Phillip E. Scherer, Xiemin Cao, Elodie M. Varin, Daniel J. Drucker, Kirandeep Kaur, Jonathan E. Campbell, Jennifer H. Stern, Jacqueline L. Beaudry, Erin E. Mulvihill
Publikováno v:
Molecular Metabolism, Vol 22, Iss, Pp 37-48 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Administration of glucagon (GCG) or GCG-containing co-agonists reduces body weight and increases energy expenditure. These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f68bfd4c4069c7e184a9d2d3ab4c2a
http://www.sciencedirect.com/science/article/pii/S2212877819300419
http://www.sciencedirect.com/science/article/pii/S2212877819300419
Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet
Autor:
Gavin Fredrickson, Fanta Barrow, Michael W. Lopresti, Douglas G. Mashek, Arnav S. Desai, Xavier S. Revelo, Breann Abernathy, Wenqi Cui
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100133-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100133-(2021)
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets in hepatocytes. NAFLD development and progression is associated with an increase in hepatic cholesterol levels and decreased autophagy and lipophagy flux.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73a9fbcf47ac6bf68281ac21b125829
https://pubmed.ncbi.nlm.nih.gov/34624333
https://pubmed.ncbi.nlm.nih.gov/34624333
Autor:
Jaekwon Lee, Yongeun Kim, Jin Seon Yook, Mi Zhou, Zhenhua Liu, Young Cheul Kim, Mikyoung You, Soonkyu Chung
Publikováno v:
The Journal of Biological Chemistry
The development of thermogenic adipocytes concurs with mitochondrial biogenesis, an iron-dependent pathway. Iron regulatory proteins (IRP) 1 and 2 are RNA-binding proteins that regulate intracellular iron homeostasis. IRPs bind to the iron-response e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a7b937089c8ea5dad2ce0b62832588
https://pubmed.ncbi.nlm.nih.gov/33631196
https://pubmed.ncbi.nlm.nih.gov/33631196