Výsledky vyhledávání - "IWAO NAKATSUKA"

Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

Autor: Masaki Kataoka, Iwao Nakatsuka, Yutaka Kon-Ya, Hiroshi Kanamaru, Masaki Ito, Masashi Yabuki, Kyoko Akao, Takeshi Shimizudani

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 28:21-29

(S)-9-chloro-5-[p-aminomethyl-o-(carboxymethoxy)phenylcarbamoylmethyl]-6,7-dihydro-1 H,5 H-pyrido[1,2,3-de]quinoxaline-2,3-dione hydrochloride trihydrate (SM-18400) was given intravenously to rats and dogs and its pharmacokinetics was investigated. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249856b6af89e9e9d50c4dde4a17615c
https://doi.org/10.1007/bf03190863

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Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ

Autor: Hideo Kaneko, Yutaka Inagaki, Noriyuki Suzuki, Alain Mauviel, Iwao Nakatsuka, Kiyoshi Higashi, Shinichi Mitsui

Publikováno v: Journal of Biological Chemistry. 278:5156-5162

We have demonstrated previously that a proximal element within the human alpha2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-gamma (IFN-gamma), and designated this region the IFN-gamma response element (IgRE).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5836e6ccde3fe5feda36fd4773c163
https://doi.org/10.1074/jbc.m208724200

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Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure tod-allethrin

Autor: Kumiko Kobayashi, Takafumi Yoshioka, Ryozo Tsuji, Tomoya Yamada, Maya Ikeda, Takaki Seki, Shiroh Kishioka, Iwao Nakatsuka, Yasuyoshi Okuno, Yoshihiro Tsuruo

Publikováno v: Journal of Applied Toxicology. 22:423-429

Synthetic pyrethroids are among the most common pesticides and insecticides currently in worldwide use. Eriksson and co-workers postulated that oral exposure of mice to pyrethroids during a neonatal brain growth spurt induces permanent disturbance in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2c9bb86a18c984844b493f6ba29a81
https://doi.org/10.1002/jat.881

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Tissue Distribution and Pharmacological Potential of SM-16896, a Novel Oestrogen-bisphosphonate Hybrid Compound

Autor: Takashi Katsumata, Hideyuki Harada, Hiroshi Kanamaru, Iwao Nakatsuka, Michihiro Yamamoto, Naomi Tsushima, Masashi Yabuki, Masashi Nakatsuka

Publikováno v: Journal of Pharmacy and Pharmacology. 52:27-37

Postmenopausal osteoporosis is caused mainly by a deficiency of oestrogen with rapid bone loss. To target oestrogen to the bone effectively, we have synthesized and evaluated the effects of a novel hybrid compound of oestrogen and bisphosphonate, SM-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f467c03259104957a28817456d1eabe0
https://doi.org/10.1211/0022357001773652

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Evaluation of a 5-day Hershberger assay using young mature male rats. Methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo

Autor: Setsuko Yabushita, Masatoshi Matsuo, Takeshi Kunimatsu, Yasuyoshi Okuno, Tomoya Yamada, Tokuo Sukata, Yusuke Kamita, Osamu Sunami, Takaki Seki, Iwao Nakatsuka, Kaori Miyata

Publikováno v: The Journal of Toxicological Sciences. 25:403-415

A 5-day Hershberger assay using young mature male rats to detect compounds interfering with androgen receptor (AR)-mediated mechanisms was evaluated for ability to identify p,p'-DDE (a weak AR antagonist) and methyltestosterone (MT, an AR agonist). F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557e77d9b444c4f935ba544a40acf9f4
https://doi.org/10.2131/jts.25.5_403

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Metabolism of 7-Fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482, Flumioxazin) in the Rat: II. Identification of Reduced Metabolites

Autor: Hideo Kaneko, Yoshitaka Tomigahara, Mihoko Onogi, Iwao Nakatsuka, Setsuo Yamane

Publikováno v: Journal of Agricultural and Food Chemistry. 47:2429-2438

On single oral administration of (14)C-S-53482 [7-fluoro-6-(3,4,5, 6-tetrahydrophthalimido)-4-(2-propynyl)-2H-1,4-benzoxazin-3( 4H)-one, Flumioxazin] labeled at the 1- and 2-positions of tetrahydrophthaloyl group to rats at 1 (low dose) or 100 (high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac404c7b0ec120edab32f2e2f566acc
https://doi.org/10.1021/jf981007r

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Metabolism of 7-Fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in Rat. 1. Identification of a Sulfonic Acid Type Conjugate

Autor: Hideo Kaneko, Setsuo Yamane, Masayoshi Matsui, Yoshitaka Tomigahara, Haruyuki Matsunaga, Naohiko Isobe, and Akira Yoshitake, Iwao Nakatsuka

Publikováno v: Journal of Agricultural and Food Chemistry. 47:305-312

To examine the metabolic fate of 7-fluoro-6-(3,4,5, 6-tetrahydrophthalimido)-4-(2-propynyl)-2H-1,4-benzoxazin-3( 4H)-one (S-53482), rats were given a single oral dose of [phenyl-(14)C]-S-53482 at 1 (low) or 100 (high) mg/kg. The radiocarbon was almos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3f20d8d68842abd35a746e133a98cb
https://doi.org/10.1021/jf980516q

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Comparison of sex differences in guinea-pig maximization test for detection of skin-sensitizing potential using OECD recommended positive control sensitizers

Autor: Yosuke Nakamura, Hiroshi Kato, Iwao Nakatsuka, Fumio Kishida, Tamaki Higaki

Publikováno v: The Journal of Toxicological Sciences. 23:105-111

Both male and female guinea pigs are widely used in tests to detect the skin-sensitizing potential of new chemicals. The aim of the present study was to investigate the influence of the animal gender on sensitization rates, with the guinea-pig maximi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ffaa35eb56cc88e7a7fc84aed1c2a1
https://doi.org/10.2131/jts.23.2_105

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