Zobrazeno 1 - 10
of 795
pro vyhledávání: '"IVT"'
Autor:
Marialuisa Zedde, Simona Lattanzi, Andrea Pilotto, Daniel Janitschke, Jakob Stögbauer, Fatma Merzou, Rosario Pascarella, Alessandro Padovani, Andrea Morotti, Piergiorgio Lochner
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundFrailty, defined as multidimensional prognostic index (MPI), has been recently identified as strong predictor of disability and mortality in the elderly with acute ischemic stroke (AIS). The stress hyperglycemia ratio (SHR) is a recently in
Externí odkaz:
https://doaj.org/article/ada513dc24c4472ca9555c7540860aca
Autor:
Robin Lenk, Werner Kleindienst, Gábor Tamás Szabó, Markus Baiersdörfer, Gábor Boros, Jason M. Keller, Azita J. Mahiny, Irena Vlatkovic
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The success of messenger (m)RNA-based vaccines against SARS-CoV-2 during the COVID-19 pandemic has led to rapid growth and innovation in the field of mRNA-based therapeutics. However, mRNA production, whether in small amounts for research or large-sc
Externí odkaz:
https://doaj.org/article/6215054dbc15478d878da43bdd41b024
Autor:
Salsano Giancarlo, Salsano Antonio, Del Sette Bruno, D’Alonzo Alessio, Sassos Davide, Alexandre Andrea, Pedicelli Alessandro, Di Iorio Riccardo, Colò Francesca, Castellan Lucio
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 2285-95 (2024)
In the absence of clinical trials, the benefit of endovascular therapy (EVT) on the treatment of acute ischemic stroke (AIS) with primary distal and medium vessel occlusions (DMVO) is still not well defined. The aim of the study is to evaluate EVT wi
Externí odkaz:
https://doaj.org/article/a88a7e58f8884677baa45eff4f547f03
Autor:
Zhixiong Zhu, Hexian Li, Qizhong Lu, Zongliang Zhang, Jia Li, Zeng Wang, Nian Yang, Zhengyu Yu, Chen Yang, Yongdong Chen, Huaqing Lu, Wei Wang, Ting Niu, Chunlai Nie, Aiping Tong
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Clinical trials of Chimeric Antigen Receptor T‐cell (CAR‐T) therapy have demonstrated remarkable success in treating both solid tumors and hematological malignancies. Nanobodies (Nbs) have emerged as promising antigen‐targeting domains
Externí odkaz:
https://doaj.org/article/8b15ce605dcc484b9a66e75fbf9aa14f
Autor:
Rui Wen, Miaoran Wang, Wei Bian, Haoyue Zhu, Ying Xiao, Jing Zeng, Qian He, Yu Wang, Xiaoqing Liu, Yangdi Shi, Linzhi Zhang, Zhe Hong, Bing Xu
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundThis investigation seeks to ascertain the efficacy of various machine learning models in forecasting early neurological deterioration (END) following thrombolysis in patients with acute ischemic stroke (AIS).MethodsEmploying data from the S
Externí odkaz:
https://doaj.org/article/9474e891e6f84e3dacd5ea1bdeee0ecf
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Recent technological advances in the production of in vitro transcribed messenger RNA (IVT‐mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not natur
Externí odkaz:
https://doaj.org/article/a0f075f2894a4596b98a60d9d9662fbb
Autor:
Androulla N. Miliotou, Sofia K. Georgiou-Siafis, Charikleia Ntenti, Ioannis S. Pappas, Lefkothea C. Papadopoulou
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9181-9214 (2023)
Over 100 innovative in vitro transcribed (IVT)-mRNAs are presently undergoing clinical trials, with a projected substantial impact on the pharmaceutical market in the near future. Τhe idea behind this is that after the successful cellular internaliz
Externí odkaz:
https://doaj.org/article/547444c00cdb46749a0d9909df47308d
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundAcute ischemic stroke (AIS) remains a leading cause of disability and mortality globally among adults. Despite Intravenous Thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) emerging as the standard treatment for AIS,
Externí odkaz:
https://doaj.org/article/9260dc5532bd4d31901405d04fa2f8f9
Publikováno v:
SLAS Technology, Vol 28, Iss 5, Pp 369-374 (2023)
One result of the Covid-19 pandemic has been an increased awareness of IVT mRNA vaccines and the speed at which they can be produced for disease outbreaks. Currently the only approved IVT mRNA therapeutics are the Covid-19 vaccines, however IVT mRNA
Externí odkaz:
https://doaj.org/article/5f4951017b694040a28981f4792d441e
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions have limited their applications
Externí odkaz:
https://doaj.org/article/afc1b18270bc438fa7f07628016ae169