Subcutaneous transplantation of engineered islet/adipose-derived mesenchymal stem cell sheets in diabetic pigs with total pancreatectomy

Autor: Shinichiro Ono, Kyoichiro Maekawa, Kengo Kanetaka, Mampei Yamashita, Tamotsu Kuroki, Masaaki Hidaka, Toshiyuki Adachi, Naomi Matsumura, Susumu Eguchi, Tomohiko Adachi, Yusuke Sakai

Publikováno v: Regenerative Therapy, Vol 16, Iss, Pp 42-52 (2021)
Regenerative Therapy

Introduction Intraportal islet transplantation is a promising therapeutic approach for patients with type 1 diabetes mellitus (T1DM). However, despite being minimally invasive, the method has some limitations, such as short-term graft loss, portal ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c069593595c8b4c866ee01a5eb3c2
http://www.sciencedirect.com/science/article/pii/S2352320420301012

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

Autor: Over Cabrera, James Ficorilli, Janice Shaw, Felipe Echeverri, Frank Schwede, Oleg G. Chepurny, Colin A. Leech, George G. Holz

Publikováno v: The Journal of Biological Chemistry

We report that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors (GcgR and GLP-1R), thereby conferring to rat islets their competence to exhibit first-phase glucose-stimulated insulin secretion (GSIS). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43acc34886e5599447ad731f8d2aba40
https://doi.org/10.1016/j.jbc.2021.101484

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

Autor: Peter Hoboth, Oliver Otto, B. P. Mulligan, Michele Solimena, Tobias Hildebrandt, Desiree M. Schumann, Anke Sönmez, Maik Herbig, Michael Meyer-Hermann, Jaber Dehghany, Hassan Mziaut, Carla Münster, Anna Ivanova, Yannis Kalaidzidis, Jochen Guck

Publikováno v: Molecular Metabolism, Vol 5, Iss 8, Pp 656-668 (2016)
Mol. Metab. 5, 656-68 (2016)
Molecular Metabolism

Objective Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51388b3180a4086174a0ea77eb14031f
http://www.sciencedirect.com/science/article/pii/S2212877816300527

Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

Autor: Grace Fergusson, Erik Joly, Marc Prentki, Camille Attané, Chloé Chrétien, Thierry Alquier, Mélanie Guévremont, Vincent Poitout, Xavier Fioramonti, Mélanie Ethier

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2014, 3 (9), pp.848-854. ⟨10.1016/j.molmet.2014.09.006⟩
Molecular Metabolism, Vol 3, Iss 9, Pp 848-854 (2014)
Molecular metabolism, Elsevier, 2014, 3 (9), pp.848-854. 〈10.1016/j.molmet.2014.09.006〉
Molecular Metabolism 9 (3), 848-854. (2014)
Molecular Metabolism

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggeste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ebde6461d5713fa9188020eb24cd11
https://hal.archives-ouvertes.fr/hal-01185658

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