Zobrazeno 1 - 10
of 150
pro vyhledávání: '"IVAN C. GERLING"'
Autor:
Chien-Wen Chen, Bo-Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya Bederman, Peter Arvan, Clayton E. Mathews, Ivan C. Gerling, Klaus H. Kaestner, Boaz Tirosh, Feyza Engin, Maria Hatzoglou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogene
Externí odkaz:
https://doaj.org/article/adc88863189241eabee325b0cf1b9532
Autor:
Francesca D’Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in di
Externí odkaz:
https://doaj.org/article/691fd79ad7294c7890d97254a673270c
Autor:
Knud Josefsen, Lars Krogvold, Ivan C. Gerling, Flemming Pociot, Knut Dahl-Jørgensen, Karsten Buschard
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundAt diagnosis of Type 1 Diabetes (T1D), 30% of the beta cells are dormant, i.e. alive, but inactive. This could reduce beta cell destruction, as cellular stress contributes to beta cell damage. However, the beta cells, that are still active,
Externí odkaz:
https://doaj.org/article/6fed8a15279949969bea1a6ea5593c12
Autor:
Lars Krogvold, Pia Leete, Ida M. Mynarek, Mark A. Russell, Ivan C. Gerling, Nataliya I. Lenchik, Clayton Mathews, Sarah J. Richardson, Noel G. Morgan, Knut Dahl-Jørgensen
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Aims/hypothesisThe Diabetes Virus Detection (DiViD) study has suggested the presence of low-grade enteroviral infection in pancreatic tissue collected from six of six live adult patients newly diagnosed with type 1 diabetes. The present study aimed t
Externí odkaz:
https://doaj.org/article/f02c08b77fd64629a1f94862a51ad465
Autor:
Martha Campbell-Thompson, Elizabeth A. Butterworth, J. Lucas Boatwright, Malavika A. Nair, Lith H. Nasif, Kamal Nasif, Andy Y. Revell, Alberto Riva, Clayton E. Mathews, Ivan C. Gerling, Desmond A. Schatz, Mark A. Atkinson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Dysregulation of glucagon secretion in type 1 diabetes (T1D) involves hypersecretion during postprandial states, but insufficient secretion during hypoglycemia. The sympathetic nervous system regulates glucagon secretion. To investigate isle
Externí odkaz:
https://doaj.org/article/06c0546e7343448f81538ebc42c845a0
Autor:
Tommi Välikangas, Niina Lietzén, Maria K. Jaakkola, Lars Krogvold, Morten C. Eike, Henna Kallionpää, Soile Tuomela, Clayton Mathews, Ivan C. Gerling, Sami Oikarinen, Heikki Hyöty, Knut Dahl-Jorgensen, Laura L. Elo, Riitta Lahesmaa
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Although type 1 diabetes (T1D) is primarily a disease of the pancreatic beta-cells, understanding of the disease-associated alterations in the whole pancreas could be important for the improved treatment or the prevention of the disease. We have char
Externí odkaz:
https://doaj.org/article/98e96d37ec7c4f9d9bac17ff104c747d
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 15, Iss , Pp 19-24 (2019)
Peripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual’s likelihood of developing PAD, but also
Externí odkaz:
https://doaj.org/article/e0c3ac87d0d84c949a3bf5205afefb5b
Autor:
Rahul Peravali, Lucas Gunnels, Karthik Dhanabalan, Folabi Ariganjoye, Ivan C. Gerling, Ayotunde O. Dokun
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 17, Iss , Pp - (2019)
Peripheral arterial disease is characterized by impaired blood flow to tissues outside the heart due to atherosclerosis and it most frequently occurs in the lower extremities. Type 2 diabetes (T2D) is a well-known risk factor that accelerate the cour
Externí odkaz:
https://doaj.org/article/af15b2690def4b918d5eb89de0024573
Publikováno v:
Cell Transplantation, Vol 9 (2000)
The objective of this study was to determine whether transfection of human islets with an adenovirus construct encoding an inhibitor of tumor necrosis factor (TNFi) was effective at limiting damage to beta cells induced by human peripheral blood leuk
Externí odkaz:
https://doaj.org/article/77e57b930108435ca750f98aef61784d
Autor:
Martin Haupt-Jorgensen, Karsten Buschard, Flemming Pociot, Kristina Pedersen, Knut Dahl-Jørgensen, Ivan C. Gerling, Simranjeet Kaur, Lars Krogvold
Publikováno v:
Diabetologia
Pedersen, K, Haupt-Jorgensen, M, Krogvold, L, Kaur, S, Gerling, I C, Pociot, F, Dahl-Jørgensen, K & Buschard, K 2021, ' Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes : potential contribution to dysregulation of innate antiviral immunity ', Diabetologia, vol. 64, no. 8, pp. 1805-1815 . https://doi.org/10.1007/s00125-021-05469-5
Pedersen, K, Haupt-Jorgensen, M, Krogvold, L, Kaur, S, Gerling, I C, Pociot, F, Dahl-Jørgensen, K & Buschard, K 2021, ' Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes : potential contribution to dysregulation of innate antiviral immunity ', Diabetologia, vol. 64, no. 8, pp. 1805-1815 . https://doi.org/10.1007/s00125-021-05469-5
Aims/hypothesis The incidence of type 1 diabetes is increasing more rapidly than can be explained by genetic drift. Viruses may play an important role in the disease, as they seem to activate the 2′-5′-linked oligoadenylate (2′-5′A) pathway o